The Infectious Diseases and Geographic Medicine training program began in 1977 and has been continuously funded since then with the most recent 5-year renewal in 2010. We seek renewal of this postdoctoral training program that has provided support for 4 postdoctoral (MD, PhD, MD PhD) trainee positions per year since 7/2010. Eight trainees have received 2 years of support and 4 new trainees were appointed in July 2014. We seek continuation of support at the current level of 4 trainee positions per year. The purpose of this training program is to teach the critical conceptual, technical and analytical skills needed for a successful and independent career in infectious disease research. The program will continue to have the following inter-related primary aims:
Aim 1 To produce research scientists that can compete successfully as independent investigators in the near future;
Aim 2 To impart broad-based knowledge of host defense to infectious agents and the molecular mechanisms that underlie infection susceptibility and disease pathogenesis, particularly with respect to infectious diseases of great health significance in resource limited areas of the world;
Aim 3 To promote training in areas that benefit from collaboration between clinical translational and basic scientists;
Aim 4 To assist trainees in career development by providing guidance and mentoring in preparation of grant applications, research conceptualization and selection of the appropriate venues for funding. Based on the history and track record of our program, we are dedicated to exposing our trainees to the following aspects of infectious disease research: 1. An interdisciplinary and collegial environment; 2. Exposure to research that is concerned with infectious disease problems of global health significance; 3. Interaction of trainees with scientists and students who work and reside in disease endemic areas of the tropics and sub-tropics; 4. Promote awareness and education of bioethics and informed consent pertinent to human subjects research; 5. Integrate the training experience into other relevant activities and programs in the CWRU School of Medicine; 6. Training in well-equipped laboratory facilities at the CWRU School of Medicine.

Public Health Relevance

Training the next generation of research scientists in infectious diseases of global significance is critically important as emerging and re-emerging infectious diseases, increasing antimicrobial resistance and the big three infections (HIV, malaria and TB) continue to pose enormous public health problems worldwide. This postdoctoral training program at Case Western Reserve University has provided this training since 1977. Research in HIV, Malaria, TB, antimicrobial resistance and host defenses against microbial pathogens continue to be major strengths of this training program.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Institutional National Research Service Award (T32)
Project #
2T32AI007024-36A1
Application #
9150909
Study Section
Microbiology and Infectious Diseases B Subcommittee (MID-B)
Program Officer
Robbins, Christiane M
Project Start
1976-07-01
Project End
2021-06-30
Budget Start
2016-08-05
Budget End
2017-07-30
Support Year
36
Fiscal Year
2016
Total Cost
$257,183
Indirect Cost
$19,051
Name
Case Western Reserve University
Department
Pathology
Type
Schools of Medicine
DUNS #
077758407
City
Cleveland
State
OH
Country
United States
Zip Code
44106
Small, Scott T; Reimer, Lisa J; Tisch, Daniel J et al. (2016) Population genomics of the filarial nematode parasite Wuchereria bancrofti from mosquitoes. Mol Ecol 25:1465-77
Harausz, Elizabeth P; Chervenak, Keith A; Good, Caryn E et al. (2016) Activity of nitazoxanide and tizoxanide against Mycobacterium tuberculosis in vitro and in whole blood culture. Tuberculosis (Edinb) 98:92-6
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Chan, Ernest R; Barnwell, John W; Zimmerman, Peter A et al. (2015) Comparative analysis of field-isolate and monkey-adapted Plasmodium vivax genomes. PLoS Negl Trop Dis 9:e0003566
Small, Scott T; Tisch, Daniel J; Zimmerman, Peter A (2014) Molecular epidemiology, phylogeny and evolution of the filarial nematode Wuchereria bancrofti. Infect Genet Evol 28:33-43
Chamanian, Mastooreh; Purzycka, Katarzyna J; Wille, Paul T et al. (2013) A cis-acting element in retroviral genomic RNA links Gag-Pol ribosomal frameshifting to selective viral RNA encapsidation. Cell Host Microbe 13:181-92
Menard, Didier; Chan, Ernest R; Benedet, Christophe et al. (2013) Whole genome sequencing of field isolates reveals a common duplication of the Duffy binding protein gene in Malagasy Plasmodium vivax strains. PLoS Negl Trop Dis 7:e2489
Small, Scott T; Ramesh, Akshaya; Bun, Krufinta et al. (2013) Population genetics of the filarial worm wuchereria bancrofti in a post-treatment region of Papua New Guinea: insights into diversity and life history. PLoS Negl Trop Dis 7:e2308
Logue, Kyle; Chan, Ernest R; Phipps, Tenisha et al. (2013) Mitochondrial genome sequences reveal deep divergences among Anopheles punctulatus sibling species in Papua New Guinea. Malar J 12:64
Ramesh, Akshaya; Small, Scott T; Kloos, Zachary A et al. (2012) The complete mitochondrial genome sequence of the filarial nematode Wuchereria bancrofti from three geographic isolates provides evidence of complex demographic history. Mol Biochem Parasitol 183:32-41

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