The Infectious Diseases Training Program is in its 34th year. The objective is to provide a rich interdisciplinary experience in infectious diseases research in order to prepare our trainees for careers as independent investigators. The cornerstone is the side-by-side education of predoctoral, M.D. and Ph.D. postdoctoral fellows. The rationale is that integration of clinical and basic science provides the varied perspectives and techniques required for creative research to combat infections. The design includes a an Executive Committee that selects predoctoral trainees from a pool of rising 2nd year graduate students, and selects postdoctoral applicants based on nominations from both mentors and the Infectious Diseases Division. Training is enriched by the monthly Research in Progress for trainees chaired by the Director, graduate courses taught by Program faculty, MS &MPH degrees in clinical investigation, seminars, research day, annual faculty retreat and journal clubs. Trainees are also taught the responsible conduct of research and are provided instruction in grant writing and laboratory and project management. The 27 faculty are 96% NIH supported (mean annual direct costs $852,000), interactive, senior (18/26 full Professors, although select "up and coming" junior faculty are included), from 8 Departments, with 20 PhDs, 11 MDs, and 1 DVM. The average mentor trained 7 pre- and 9 postdocs in the last 10 years, 94% of whom remain in research. Evaluation of the Program includes an annual faculty retreat, trainee and graduate questionnaire and External Advisory Committee site visits. Institutional support includes funding of all 1st year predoctoral fellows, the seminar series, and construction of a new research building occupied last year by 53% (16/27) of mentors. NIH support is requested for 5 predoctoral, 5 M.D. and 2 Ph.D. postdoctoral fellows (no change from the prior funding period). The average matriculated predoctoral student in Infectious Diseases Program has GRE scores of 570/704/4.7 and a grade point average of 3.63. Admission is highly competitive, with only 31% (5/16) of rising 2nd year predoctoral trainees accepted by the Program in 2010 despite their expressed interest in infectious diseases and their excellent qualifications. Progress since the last funding period includes 100% retention of trainees in the Program, and a 24% increase in mentor extramural support. 97% of predoctoral and 90% of postdoctoral fellows graduates in the last 10 years remain in research. Peer-reviewed original publications average 3.5 for graduating fellows. Underrepresented minorities comprise 15% of postdoctoral fellows for both the last 5 and 10 years, and 28% (5/18) and 25% (5/20) of predoctoral fellows supported for the last 5 and 10 respectively (including for predocs individuals with disabilities and disadvantaged). For the 10 year period, 21% of trainees are under-represented minority, disabled or disadvantaged. Academic and research positions are held by 84% (21/25) of postdoctoral and 95% (19/20) of predoctoral graduates, and 7 K awards and 3 individual fellowships have been awarded.
The Program prepares fellows to conduct research on infectious diseases, a paramount threat to international health in the 21st century.
|Enfield, Kyle B; Huq, Nujhat N; Gosseling, Megan F et al. (2014) Control of simultaneous outbreaks of carbapenemase-producing enterobacteriaceae and extensively drug-resistant Acinetobacter baumannii infection in an intensive care unit using interventions promoted in the Centers for Disease Control and Prevention 2012 Infect Control Hosp Epidemiol 35:810-7|
|Platts-Mills, James A; Gratz, Jean; Mduma, Esto et al. (2014) Association between stool enteropathogen quantity and disease in Tanzanian children using TaqMan array cards: a nested case-control study. Am J Trop Med Hyg 90:133-8|
|Anderson, Melissa S; Loftus, Matthew S; Kedes, Dean H (2014) Maturation and vesicle-mediated egress of primate gammaherpesvirus rhesus monkey rhadinovirus require inner tegument protein ORF52. J Virol 88:9111-28|
|Ralston, Katherine S; Solga, Michael D; Mackey-Lawrence, Nicole M et al. (2014) Trogocytosis by Entamoeba histolytica contributes to cell killing and tissue invasion. Nature 508:526-30|
|Bartelt, Luther A; Guerrant, Richard L (2014) Antibiotics help control rotavirus infections and enhance antirotaviral immunity: are you serious? J Infect Dis 210:167-70|
|Platts-Mills, James A; Liu, Jie; Gratz, Jean et al. (2014) Detection of Campylobacter in stool and determination of significance by culture, enzyme immunoassay, and PCR in developing countries. J Clin Microbiol 52:1074-80|
|Day, Shandra R; Weiss, David B; Hazen, Kevin C et al. (2014) Successful treatment of osseous blastomycosis without pulmonary or disseminated disease and review of the literature. Diagn Microbiol Infect Dis 79:242-4|
|Madan, Rajat; Guo, Xiaoti; Naylor, Caitlin et al. (2014) Role of leptin-mediated colonic inflammation in defense against Clostridium difficile colitis. Infect Immun 82:341-9|
|Schafer, Katherine R; Gupta, Shruti; Dillingham, Rebecca (2013) HIV-infected men who have sex with men and histories of childhood sexual abuse: implications for health and prevention. J Assoc Nurses AIDS Care 24:288-98|
|Mackey-Lawrence, Nicole M; Guo, Xiaoti; Sturdevant, Daniel E et al. (2013) Effect of the leptin receptor Q223R polymorphism on the host transcriptome following infection with Entamoeba histolytica. Infect Immun 81:1460-70|
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