In the current funding period of this long-standing training grant, eleven students were funded and four students completed their Ph.D. Overall, since its inception in 1971, the Immunology Graduate Program at the University of Connecticut Health Center (UCHC) has awarded 88 Ph.D. degrees. Our graduates have obtained high quality positions in academic, clinical, industrial and governmental research settings. The Training Grant Faculty is comprised of 14 members providing expertise in teaching and in highly relevant research areas of immunology, including microbial immunity, cancer immunology and immunotherapy, vaccine development, autoimmunity, allergy, mucosal immunology, immunoregulation and lymphocyte development. Furthermore, the facilities at UCHC for application to research projects and for student training in modern techniques are state-of-the-art. Thus, our institution and our faculty continue to provide the breadth and depth in immunology research required to train and produce successful scientists. As in the past, the central focus of our program will be to train students to become independent investigators and educators who-will contribute importantly to expanding knowledge in the areas of basic and/or applied immunology. This goal will be achieved by formal coursework, research seminars, supervised thesis research, individualized instruction and guidance, formal presentations at journal clubs, biannual progress reports, attendance at scientific meetings and writing manuscripts. The training obtained through this tested program with the help of this training grant will not only give the student a strong foundation in modern laboratory techniques but will help to develop his/her ability to conceive and solve experimental problems to critically evaluate data;and to effectively communicate information verbally and in writing.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Institutional National Research Service Award (T32)
Project #
5T32AI007080-27
Application #
7790694
Study Section
Allergy & Clinical Immunology-1 (AITC)
Program Officer
Prograis, Lawrence J
Project Start
1977-09-01
Project End
2013-05-31
Budget Start
2010-06-01
Budget End
2011-05-31
Support Year
27
Fiscal Year
2010
Total Cost
$163,737
Indirect Cost
Name
University of Connecticut
Department
Microbiology/Immun/Virology
Type
Schools of Medicine
DUNS #
022254226
City
Farmington
State
CT
Country
United States
Zip Code
06030
Bracken, Sonali J; Adami, Alexander J; Szczepanek, Steven M et al. (2015) Long-Term Exposure to House Dust Mite Leads to the Suppression of Allergic Airway Disease Despite Persistent Lung Inflammation. Int Arch Allergy Immunol 166:243-58
Hammond, Matthew D; Taylor, Roslyn A; Mullen, Michael T et al. (2014) CCR2+ Ly6C(hi) inflammatory monocyte recruitment exacerbates acute disability following intracerebral hemorrhage. J Neurosci 34:3901-9
Bose, Tina O; Colpitts, Sara L; Pham, Quynh-Mai et al. (2014) CD11a is essential for normal development of hematopoietic intermediates. J Immunol 193:2863-72
Wright, Kyle T; Vella, Anthony T (2013) RKIP contributes to IFN-γ synthesis by CD8+ T cells after serial TCR triggering in systemic inflammatory response syndrome. J Immunol 191:708-16
Bose, Tina O; Pham, Quynh-Mai; Jellison, Evan R et al. (2013) CD11a regulates effector CD8 T cell differentiation and central memory development in response to infection with Listeria monocytogenes. Infect Immun 81:1140-51
St Rose, Marie-Clare; Taylor, Roslyn A; Bandyopadhyay, Suman et al. (2013) CD134/CD137 dual costimulation-elicited IFN-γ maximizes effector T-cell function but limits Treg expansion. Immunol Cell Biol 91:173-83
McNamara, Jeffrey T; Schramm, Craig M; Singh, Anurag et al. (2012) Phenotypic changes to the endogenous antigen-specific CD8+ T cell response correlates with the development and resolution of allergic airway disease. Am J Pathol 180:1991-2000
Jellison, Evan R; Turner, Michael J; Blair, David A et al. (2012) Distinct mechanisms mediate naive and memory CD8 T-cell tolerance. Proc Natl Acad Sci U S A 109:21438-43
Obar, Joshua J; Jellison, Evan R; Sheridan, Brian S et al. (2011) Pathogen-induced inflammatory environment controls effector and memory CD8+ T cell differentiation. J Immunol 187:4967-78
Qui, Harry Z; Hagymasi, Adam T; Bandyopadhyay, Suman et al. (2011) CD134 plus CD137 dual costimulation induces Eomesodermin in CD4 T cells to program cytotoxic Th1 differentiation. J Immunol 187:3555-64

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