This Training Grant, currently in its 35th year of funding, represents the primary support for graduate students in the Immunology Training Program at the University of Chicago. The Program is conducted in a diverse environment where the basic biological sciences and the medical school and clinical programs are integrated within the same Division in a single Campus in Hyde Park, Chicago, IL. It is embodied by the Committee on Immunology, an interdisciplinary and interdepartmental academic unit, which includes some of the most distinguished and productive faculty in various Departments. The faculty is composed of 31 trainers selected for their outstanding research and training record, their well-funded laboratory and their dynamic involvement in all aspects of the Program. They form a diverse, age and gender-balanced group, whose research spans a broad spectrum of basic as well as translational Immunology, including modern or emerging areas such as live imaging, genomics and systems biology, microbiome studies, chemical biology, molecular engineering and human immunology. Predoctoral students receive advanced training in Immunology through a formal series of courses, including a core basic curriculum and electives from a wide range of scientific disciplines, and laboratory rotations. The comprehensive training also includes a weekly Journal Club, Work-in-Progress and Seminar Series, and an annual two-day Retreat. All predocs and postdocs receive training in responsible conduct of research. Career development is enhanced through a dedicated career seminar series, formal training for grantsmanship, and partnership with UChicago Booth School of Business to develop biomedical entrepreneurship. There is strong institutional support, shown by the major allocation of new space, the regroupment of faculty in a new """"""""Immunology Hub"""""""" at the center of the renovated campus, the sustained financial and administrative support from the Biomedical Science Division. New strength is drawn from the recruitment of immunology training faculty in emerging areas such as microbiome studies and in physical sciences, such as chemical biology, computational biology and molecular engineering, with a proven record of interdisciplinary collaborations. The Program is continuously and rigorously evaluated with respect to organization, leadership, objectives and outcomes. With a world-renowned group of dynamic faculty and a large pool of exceptionally qualified applicants, this is one of the best and most competitive training program in the country, as shown by the high retention and completion rates of our trainees, which include many underrepresented minority students, their impressive publication rate (average of 6 publications/per trainee, including in highest impact journals such as Nature, Science, Cell) and their success in securing independent scientific careers with many tenure-track academic positions. Based on this track record of success and growth, continued support is requested with an increment of two slots.

Public Health Relevance

This Program trains the next generation of Immunologists who will lead the innovative research, teaching and biomedical entrepreneurship that is needed to advance basic science and develop new translational approaches for prevention and treatment of autoimmune diseases and cancer, improvement of organ transplant and for the design of new and more efficient vaccines. The funding will contribute to Public Health by supporting the training of highly skilled individuals who will join the national Biomedical Research Workforce.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Institutional National Research Service Award (T32)
Project #
2T32AI007090-36
Application #
8741310
Study Section
Special Emphasis Panel (ZAI1)
Program Officer
Prograis, Lawrence J
Project Start
1979-07-01
Project End
2019-06-30
Budget Start
2014-07-01
Budget End
2015-06-30
Support Year
36
Fiscal Year
2014
Total Cost
Indirect Cost
Name
University of Chicago
Department
Pathology
Type
Schools of Medicine
DUNS #
City
Chicago
State
IL
Country
United States
Zip Code
60637
Zook, Erin C; Ramirez, Kevin; Guo, Xiaohuan et al. (2016) The ETS1 transcription factor is required for the development and cytokine-induced expansion of ILC2. J Exp Med 213:687-96
Leventhal, Daniel S; Gilmore, Dana C; Berger, Julian M et al. (2016) Dendritic Cells Coordinate the Development and Homeostasis of Organ-Specific Regulatory T Cells. Immunity 44:847-59
Grimm, Wesley A; Messer, Jeannette S; Murphy, Stephen F et al. (2016) The Thr300Ala variant in ATG16L1 is associated with improved survival in human colorectal cancer and enhanced production of type I interferon. Gut 65:456-64
Block, Katharine E; Zheng, Zhong; Dent, Alexander L et al. (2016) Gut Microbiota Regulates K/BxN Autoimmune Arthritis through Follicular Helper T but Not Th17 Cells. J Immunol 196:1550-7
Curran, Emily; Chen, Xiufen; Corrales, Leticia et al. (2016) STING Pathway Activation Stimulates Potent Immunity against Acute Myeloid Leukemia. Cell Rep 15:2357-66
Perera, Jason; Zheng, Zhong; Li, Shuyin et al. (2016) Self-Antigen-Driven Thymic B Cell Class Switching Promotes T Cell Central Tolerance. Cell Rep 17:387-398
Thomer, Lena; Emolo, Carla; Thammavongsa, Vilasack et al. (2016) Antibodies against a secreted product of Staphylococcus aureus trigger phagocytic killing. J Exp Med 213:293-301
Wilks, Jessica; Lien, Egil; Jacobson, Amy N et al. (2015) Mammalian Lipopolysaccharide Receptors Incorporated into the Retroviral Envelope Augment Virus Transmission. Cell Host Microbe 18:456-62
Tu, Tony C; Brown, Nicholas K; Kim, Tae-Jin et al. (2015) CD160 is essential for NK-mediated IFN-γ production. J Exp Med 212:415-29
Zhu, Xiaorong; Messer, Jeannette S; Wang, Yunwei et al. (2015) Cytosolic HMGB1 controls the cellular autophagy/apoptosis checkpoint during inflammation. J Clin Invest 125:1098-110

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