The UCSF Immunology Training Program encompasses 46 laboratories engaged in molecular, cellular, and in vivo immunology and actively training ~250 graduate and postdoctoral scientists. Areas of active research include many areas of contemporary immunology such as lymphocyte cell surface receptor function and mechanisms of signaling; mechanisms of innate immune recognition; lymphocyte and leukocyte cell biology, adhesion and migration; cytokine expression and in vivo function; CD4 T cell effector and regulatory function; cytotoxic T cell and NK cell function; microRNA regulation of immune cell function, lymphocyte development, hematopoiesis and their relationship to leukemia and lymphoma; in vivo mechanisms of autoimmunity, allergy, and inflammatory diseases; human immunodeficiency; and immune defense against infectious agents including malaria, Histoplasma, Tuberculosis, and HIV. Over the past 29 years, a vital graduate training program leading to the Ph.D. has been developed by the immunology program faculty and has been supported by this training grant for the past 25 years. This program is designed to provide a solid background in genetics, cell biology, molecular biology, and mammalian tissue and organ biology as well as thorough training in modern immunology. The interdisciplinary nature of this training is enhanced by the affiliation of the Immunology Program with the UCSF Biomedical Sciences Program (BMS), an interdisciplinary program that also includes the study of infectious agents and inflammatory processes as well as other aspects of mammalian tissue/organ development, function, and disease. In addition to formal coursework and thesis research, the Immunology Program includes an active weekly seminar series of outside immunology speakers, both Immunology and BMS student-faculty journal clubs, an annual Immunology Program Retreat (held jointly with UC Berkeley immunologists), and seminar courses on advanced immunological topics. These activities provide an excellent training environment for postdoctoral fellows as well as for graduate students. Postdoctoral training is additionally enhanced by a postdoc research-in-progress seminar series and a recently developed postdoctoral mentoring program.

Public Health Relevance

Immunology is the study of the immune system, the major natural purpose of which is to defend us against infections. Additionally, it has been found that the immune system protects us from cancer, but when dysregulated causes tissue damage in autoimmune, allergic, and inflammatory diseases, and contributes importantly to the tissue damage and loss of function in a number of chronic diseases including atherosclerosis (heart disease and stroke), type 2 diabetes, and probably several degenerative neurological diseases such as Alzheimer's disease. This training program trains the next generation of scientists to study the immune system and develop new therapeutic approaches for its modulation as needed to ameliorate disease.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Institutional National Research Service Award (T32)
Project #
5T32AI007334-29
Application #
9282671
Study Section
Allergy, Immunology, and Transplantation Research Committee (AITC)
Program Officer
Gondre-Lewis, Timothy A
Project Start
1988-09-01
Project End
2019-07-31
Budget Start
2017-08-01
Budget End
2018-07-31
Support Year
29
Fiscal Year
2017
Total Cost
Indirect Cost
Name
University of California San Francisco
Department
Microbiology/Immun/Virology
Type
Schools of Medicine
DUNS #
094878337
City
San Francisco
State
CA
Country
United States
Zip Code
94118
Takasaka, Naoki; Seed, Robert I; Cormier, Anthony et al. (2018) Integrin ?v?8-expressing tumor cells evade host immunity by regulating TGF-? activation in immune cells. JCI Insight 3:
Publicover, Jean; Gaggar, Anuj; Jespersen, Jillian M et al. (2018) An OX40/OX40L interaction directs successful immunity to hepatitis B virus. Sci Transl Med 10:
Trapecar, Martin; Khan, Shahzada; Cohn, Benjamin L et al. (2018) B cells are the predominant mediators of early systemic viral dissemination during rectal LCMV infection. Mucosal Immunol 11:1158-1167
Nancy, Patrice; Siewiera, Johan; Rizzuto, Gabrielle et al. (2018) H3K27me3 dynamics dictate evolving uterine states in pregnancy and parturition. J Clin Invest 128:233-247
Jeng, Mark Y; Hull, Philip A; Fei, Mingjian et al. (2018) Metabolic reprogramming of human CD8+ memory T cells through loss of SIRT1. J Exp Med 215:51-62
Kara, Ervin E; Bastow, Cameron R; McKenzie, Duncan R et al. (2018) Atypical chemokine receptor 4 shapes activated B cell fate. J Exp Med 215:801-813
Ali, Ibraheem; Conrad, Ryan J; Verdin, Eric et al. (2018) Lysine Acetylation Goes Global: From Epigenetics to Metabolism and Therapeutics. Chem Rev 118:1216-1252
Scharschmidt, Tiffany C; Vasquez, Kimberly S; Pauli, Mariela L et al. (2017) Commensal Microbes and Hair Follicle Morphogenesis Coordinately Drive Treg Migration into Neonatal Skin. Cell Host Microbe 21:467-477.e5
Lefrançais, Emma; Ortiz-Muñoz, Guadalupe; Caudrillier, Axelle et al. (2017) The lung is a site of platelet biogenesis and a reservoir for haematopoietic progenitors. Nature 544:105-109
English, Bevin C; Van Prooyen, Nancy; Örd, Tiit et al. (2017) The transcription factor CHOP, an effector of the integrated stress response, is required for host sensitivity to the fungal intracellular pathogen Histoplasma capsulatum. PLoS Pathog 13:e1006589

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