This pre-doctoral training program is sponsored by the Department of Microbiology and Immunology at the University of Rochester. Many primary faculty members of the training program are also from other Departments, including Neurology, Cancer Center, Biochemistry, Medicine and Dental Medicine. Dr. Barbara Iglewski is the Program Director. She is the Chairman of the Department of Microbiology. The Program will be administered by a Steering Committee composed of Drs. B. Iglewski, P. Bavoil, D. McCance, V. Clark and R. Richman. Dr. Richman is from the Department of Medicine and has a joint appointment in the Department of Microbiology and Immunology, whereas the four other members are primarily appointed in the Department of Microbiology and Immunology. Decisions will be made by the Steering Committee. The Steering Committee will meet at least four times annually to review the progress of individual trainees and assign pre-doctoral students to the Training Program based primarily on the quality, and research interests of the trainees and on the ability of the advisors to provide the appropriate research environment. They will meet with all participating faculty at least annually to discuss the program. The new core curriculum was implemented in 1989 during the previous grant period to address the specific needs of this Pathogenesis training program. This training program is composed of four major academic components; there are a required curriculum, an elective curriculum, thesis research and ancillary professional training. The core curriculum consists of one semester of Biochemistry, a seminar in Microbiology and Immunology, laboratory rotations, and Ethics in Research. In addition, students are required to take four courses chosen from a list which includes topics in the Microbial Genetics, Microbial Physiology, Immunology, Genetics, and Biochemistry. All students are also required to take a seminar course for at least one semester per year in a range of topics from Immunology to Oral Microbiology. Furthermore, the students are required to participate in a series of colloquia and seminars sponsored by the Department of Microbiology and Immunology. All students are also be required to teach for one semester within the Department of Microbiology and Immunology. The projected time for completion of the Ph.D. is five years, with years two through five of the program to be funded through this grant. The first year will be supported through departmental funds. The candidates are expected to choose a research advisor during the first year, and they must pass a qualifying exam before matriculating for the third year. The qualifying exam will be administered by the Steering Committee with active involvement of the student's preceptor. The exam will consist essentially of detailed presentation of a research proposal different from the student's dissertation work. Dissertation research is carried out in the laboratory of the dissertation advisor with the guidance of a committee which includes the student's faculty advisor, at least one other member of the training program, and at least one other advisor from outside the Department of Microbiology and Immunology.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Institutional National Research Service Award (T32)
Project #
5T32AI007362-10
Application #
2886183
Study Section
Microbiology and Infectious Diseases B Subcommittee (MID)
Program Officer
Quackenbush, Robert L
Project Start
1990-09-30
Project End
2000-08-31
Budget Start
1999-09-01
Budget End
2000-08-31
Support Year
10
Fiscal Year
1999
Total Cost
Indirect Cost
Name
University of Rochester
Department
Microbiology/Immun/Virology
Type
Schools of Dentistry
DUNS #
208469486
City
Rochester
State
NY
Country
United States
Zip Code
14627
Miller, Kelly A; Chaand, Mudit; Gregoire, Stacy et al. (2016) Characterization of V. cholerae T3SS-dependent cytotoxicity in cultured intestinal epithelial cells. Cell Microbiol 18:1857-1870
Miller, Kelly A; Sofia, Madeline K; Weaver, Jacob W A et al. (2016) Regulation by ToxR-Like Proteins Converges on vttRB Expression To Control Type 3 Secretion System-Dependent Caco2-BBE Cytotoxicity in Vibrio cholerae. J Bacteriol 198:1675-1682
LoVullo, Eric D; Wright, Lori F; Isabella, Vincent et al. (2015) Revisiting the Gram-negative lipoprotein paradigm. J Bacteriol 197:1705-15
Sanders, Akeisha N; Wright, Lori F; Pavelka Jr, Martin S (2014) Genetic characterization of mycobacterial L,D-transpeptidases. Microbiology 160:1795-806
Perez-Nazario, Nelissa; Rangel-Moreno, Javier; O'Reilly, Michael A et al. (2013) Selective ablation of lung epithelial IKK2 impairs pulmonary Th17 responses and delays the clearance of Pneumocystis. J Immunol 191:4720-30
Sanders, Akeisha N; Pavelka, Martin S (2013) Phenotypic analysis of Eschericia coli mutants lacking L,D-transpeptidases. Microbiology 159:1842-52
Desmet, Emily A; Bussey, Kendra A; Stone, Raychel et al. (2013) Identification of the N-terminal domain of the influenza virus PA responsible for the suppression of host protein synthesis. J Virol 87:3108-18
Chan, Winnie M; Ward, Brian M (2012) Increased interaction between vaccinia virus proteins A33 and B5 is detrimental to infectious extracellular enveloped virion production. J Virol 86:8232-44
Miller, Kelly A; Hamilton, Elaine; Dziejman, Michelle (2012) The Vibrio cholerae trh gene is coordinately regulated in vitro with type III secretion system genes by VttR(A)/VttR(B) but does not contribute to Caco2-BBE cell cytotoxicity. Infect Immun 80:4444-55
Chan, Winnie M; Ward, Brian M (2012) The A33-dependent incorporation of B5 into extracellular enveloped vaccinia virions is mediated through an interaction between their lumenal domains. J Virol 86:8210-20

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