The primary purpose of this training grant program is the development of scientific leaders for careers in HIV/AIDS research. The current expanding epidemic of HIV infection demands commitment of investigators to the training of a new generation of leaders in research. It is anticipated that graduates of this postdoctoral program will follow careers in research related to AIDS. This program will provide in depth laboratory experience in a specific research area of virology, immunology, molecular biology, oncology, epidemiology molecular genetics, or molecular therapeutics to selected candidates. Trainees will be MDs after completion of their clinical residencies and specialty training or PhDs and ScDs from an appropriate basic science program. Criteria for selection will include prior training record, aptitude for research and commitment to research careers. All applicants will be selected by a Program Steering Committee, and six will be selected annually. Particular emphasis will be given to the recruitment of minorities and others underrepresented in AIDS research, e.g., women, individuals with disabilities, and those from disadvantaged backgrounds. The basic elements of the program are: 1) in depth research training through laboratory investigation of a specific problem in a particular area related to AIDS under a senior investigator;2) a didactic program consisting of appropriately chosen specific courses which will advance the trainee's knowledge;3) frequent exposure to seminars, workshops, and colloquia related to AIDS;4) regular review of progress by individual Progress Evaluation Committees and the Program Steering Committee. The primary training facilities consist of well equipped research laboratories at Harvard Medical School, Harvard School of Public Health, Massachusetts General Hospital, Beth Israel-Deaconess Medical Center, Brigham and Women's Hospital, the Immune Disease Institute, Dana-Farber Cancer Institute, the Ragon Institute and the New England Primate Research Center. Senior and Junior faculty at each of these institutions are on the faculty of this grant, and they represent a variety of disciplines. The faculty collaborates with one another on AIDS research and will collaborate in directing this training program.

National Institute of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
Institutional National Research Service Award (T32)
Project #
Application #
Study Section
Acquired Immunodeficiency Syndrome Research Review Committee (AIDS)
Program Officer
Williams, Carolyn F
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Massachusetts General Hospital
United States
Zip Code
Bhattacharyya, Mitra; Madden, Patrick; Henning, Nathan et al. (2017) Regulation of CD4 T cells and their effects on immunopathological inflammation following viral infection. Immunology 152:328-343
Penaloza MacMaster, Pablo; Shields, Jennifer L; Alayo, Quazim A et al. (2017) Development of novel replication-defective lymphocytic choriomeningitis virus vectors expressing SIV antigens. Vaccine 35:1-9
Viganò, Selena; Negrón, Jordi J; Tse, Samantha et al. (2017) HLA-G+ HIV-1-specific CD8+ T cells are associated with HIV-1 immune control. AIDS 31:207-212
Lu, Lenette L; Chung, Amy W; Rosebrock, Tracy R et al. (2016) A Functional Role for Antibodies in Tuberculosis. Cell 167:433-443.e14
Scully, Eileen P; Lockhart, Ainsley; Garcia-Beltran, Wilfredo et al. (2016) Innate immune reconstitution with suppression of HIV-1. JCI Insight 1:e85433
Provine, Nicholas M; Badamchi-Zadeh, Alexander; Bricault, Christine A et al. (2016) Transient CD4+ T Cell Depletion Results in Delayed Development of Functional Vaccine-Elicited Antibody Responses. J Virol 90:4278-88
Sadanand, Saheli; Suscovich, Todd J; Alter, Galit (2016) Broadly Neutralizing Antibodies Against HIV: New Insights to Inform Vaccine Design. Annu Rev Med 67:185-200
Larocca, Rafael A; Provine, Nicholas M; Aid, Malika et al. (2016) Adenovirus serotype 5 vaccine vectors trigger IL-27-dependent inhibitory CD4+T cell responses that impair CD8+T cell function. Sci Immunol 1:
Provine, Nicholas M; Larocca, Rafael A; Aid, Malika et al. (2016) Immediate Dysfunction of Vaccine-Elicited CD8+ T Cells Primed in the Absence of CD4+ T Cells. J Immunol 197:1809-22
Piantadosi, Anne; Rubin, Daniel B; McQuillen, Daniel P et al. (2016) Emerging Cases of Powassan Virus Encephalitis in New England: Clinical Presentation, Imaging, and Review of the Literature. Clin Infect Dis 62:707-713

Showing the most recent 10 out of 119 publications