This application proposes continuation of the Interdisciplinary Research Training Program in AIDS (IRTPA) at Duke University where an exceptional group of basic scientists and clinical researchers has been assembled under the direction of the Duke Center for AIDS Research (CFAR). A large funding base from diverse sources (exceeding $50 million) provides a wide range of opportunities for research with the scientists who comprise the IRTPA faculty. Since the last re-competition of this grant, an international component has been added under the umbrella of the Duke Global Health Institute, further enriching the research environment. Over the previous 19 years of the grant, the program has had considerable success, consistently filling all available training slots (54 research trainees [22 MDs, 31 PhDs, 1 MD/PhD]). Almost 90% of graduates have been hired to positions in academia, biomedical research, or public health. These achievements reflect the careful selection of highly qualified and motivated young researchers, nurtured in an exceptionally rich training environment. Opportunities for HIV-associated research training at Duke include both basic science and clinical research. Potential training sites include: 1) Human Vaccine Institute (Bart Haynes, MD), offering basic science research into immune responses in HIV-infected persons;2) HIV Pathogenesis research (Bryan Cullen, Ph.D.) offering basic virology research opportunities;3) Acute HIV infection and clinical research studies (Charles Hicks, MD);4) HIV Opportunistic infections research (Jason Stout, MD) offering research into mycobacterial, fungal, and viral co-infections as well as other HIV-associated disorders;5) Pediatric HIV research (Coleen Cunningham, MD) focusing on a range of maternal-infant, pediatric and adolescent HIV research studies;6) International HIV research (John Bartlett, MD) with HIV research done in Tanzania in collaboration with the Global Health Institute;and 8) other research options including the potential to develop research studies in behavioral medicine and social issues to include access to care and health inequalities, led by Kate Whetten, Ph.D. The Duke Interdisciplinary Research Training Program in AIDS is positioned to continue and expand its ongoing record of success.

Public Health Relevance

Although HIV is becoming a chronic, manageable disease, much remains to be done. Disappointing HIV vaccine trials, long-term toxicities from antiretroviral therapy, and failure to diagnosis many persons infected are only a few of the challenges that remain worldwide. Training the next generation of HIV research scientists is crucial to the solution to these problems. The Duke IRTPA will provide training for both basic scientists and clinical researchers to move the research agenda forward.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Institutional National Research Service Award (T32)
Project #
5T32AI007392-24
Application #
8487332
Study Section
Acquired Immunodeficiency Syndrome Research Review Committee (AIDS)
Program Officer
Sharma, Opendra K
Project Start
1990-08-01
Project End
2015-08-31
Budget Start
2013-09-01
Budget End
2014-08-31
Support Year
24
Fiscal Year
2013
Total Cost
$370,125
Indirect Cost
$27,417
Name
Duke University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
044387793
City
Durham
State
NC
Country
United States
Zip Code
27705
Payne, Tamika L; Blackinton, Jeff; Frisbee, Alyse et al. (2014) Transcriptional and posttranscriptional regulation of cytokine gene expression in HIV-1 antigen-specific CD8+ T cells that mediate virus inhibition. J Virol 88:9514-28
Pollara, Justin; Bonsignori, Mattia; Moody, M Anthony et al. (2014) HIV-1 vaccine-induced C1 and V2 Env-specific antibodies synergize for increased antiviral activities. J Virol 88:7715-26
Biggs, Holly M; Lester, Rebecca; Nadjm, Behzad et al. (2014) Invasive Salmonella infections in areas of high and low malaria transmission intensity in Tanzania. Clin Infect Dis 58:638-47
Reddy, Elizabeth A; Njau, Boniface N; Morpeth, Susan C et al. (2014) A randomized controlled trial of standard versus intensified tuberculosis diagnostics on treatment decisions by physicians in Northern Tanzania. BMC Infect Dis 14:89
Williams, LaTonya D; Amatya, Nilesh; Bansal, Anju et al. (2014) Immune activation is associated with CD8 T cell interleukin-21 production in HIV-1-infected individuals. J Virol 88:10259-63
Nikitin, Pavel A; Price, Alexander M; McFadden, Karyn et al. (2014) Mitogen-induced B-cell proliferation activates Chk2-dependent G1/S cell cycle arrest. PLoS One 9:e87299
Bogerd, Hal P; Skalsky, Rebecca L; Kennedy, Edward M et al. (2014) Replication of many human viruses is refractory to inhibition by endogenous cellular microRNAs. J Virol 88:8065-76
Flores, Omar; Kennedy, Edward M; Skalsky, Rebecca L et al. (2014) Differential RISC association of endogenous human microRNAs predicts their inhibitory potential. Nucleic Acids Res 42:4629-39
Moon, Andrew M; Biggs, Holly M; Rubach, Matthew P et al. (2014) Evaluation of in-hospital management for febrile illness in Northern Tanzania before and after 2010 World Health Organization Guidelines for the treatment of malaria. PLoS One 9:e89814
Norton, Brianna L; Person, Anna K; Castillo, Catherine et al. (2014) Barriers to using text message appointment reminders in an HIV clinic. Telemed J E Health 20:86-9

Showing the most recent 10 out of 70 publications