This program seeks renewal of a program for post-doctoral training of physician and non-physician scientists in basic and translational immunology side-by-side in the rich, shared environment of the Department of Immunology at the University of Washington. The ultimate goal of the program is to develop the next generation of investigators, who will make important contributions to our understanding of fundamental immunology and of normal and abnormal immune function relevant to human immunological and infectious diseases. The physician and non-physician post-docs in our program complement each other: The physician investigators bring to the program unique perspectives derived from direct interaction with patients and laboratory research experience of varying degrees. The non-physician, Ph.D. trainees bring to the program a rich background of didactic and laboratory research experience, but limited familiarity with the potential clinical ramifications of their work. The key quality sought in all trainees is a clear commitment and outstanding potential for research.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Institutional National Research Service Award (T32)
Project #
5T32AI007411-20
Application #
8277071
Study Section
Allergy & Clinical Immunology-1 (AITC)
Program Officer
Prograis, Lawrence J
Project Start
1993-07-01
Project End
2014-03-30
Budget Start
2012-07-01
Budget End
2014-03-30
Support Year
20
Fiscal Year
2012
Total Cost
$214,422
Indirect Cost
$16,795
Name
University of Washington
Department
Microbiology/Immun/Virology
Type
Schools of Medicine
DUNS #
605799469
City
Seattle
State
WA
Country
United States
Zip Code
98195
Bell, Bryan D; Kitajima, Masayuki; Larson, Ryan P et al. (2013) The transcription factor STAT5 is critical in dendritic cells for the development of TH2 but not TH1 responses. Nat Immunol 14:364-71
Larson, Ryan P; Shafiani, Shahin; Urdahl, Kevin B (2013) Foxp3(+) regulatory T cells in tuberculosis. Adv Exp Med Biol 783:165-80
Ziegler, Steven F; Roan, Florence; Bell, Bryan D et al. (2013) The biology of thymic stromal lymphopoietin (TSLP). Adv Pharmacol 66:129-55
Roan, Florence; Bell, Bryan D; Stoklasek, Thomas A et al. (2012) The multiple facets of thymic stromal lymphopoietin (TSLP) during allergic inflammation and beyond. J Leukoc Biol 91:877-86
Sacho, Elizabeth J; Maizels, Nancy (2011) DNA repair factor MRE11/RAD50 cleaves 3'-phosphotyrosyl bonds and resects DNA to repair damage caused by topoisomerase 1 poisons. J Biol Chem 286:44945-51
Thompson, Lucas J; Valladao, Andrea C; Ziegler, Steven F (2011) Cutting edge: De novo induction of functional Foxp3+ regulatory CD4 T cells in response to tissue-restricted self antigen. J Immunol 186:4551-5
Oestreich, Kenneth J; Huang, Albert C; Weinmann, Amy S (2011) The lineage-defining factors T-bet and Bcl-6 collaborate to regulate Th1 gene expression patterns. J Exp Med 208:1001-13
Lord, James D; Hackman, Robert C; Gooley, Ted A et al. (2011) Blood and gastric FOXP3+ T cells are not decreased in human gastric graft-versus-host disease. Biol Blood Marrow Transplant 17:486-96
Wesley, Johnna D; Sather, Blythe D; Perdue, Nikole R et al. (2010) Cellular requirements for diabetes induction in DO11.10xRIPmOVA mice. J Immunol 185:4760-8
Stromnes, Ingunn M; Blattman, Joseph N; Tan, Xiaoxia et al. (2010) Abrogating Cbl-b in effector CD8(+) T cells improves the efficacy of adoptive therapy of leukemia in mice. J Clin Invest 120:3722-34

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