Proposed is the continuation of a predoctoral training program in cellular and molecular parasitology (CMP) that will provide trainees excellent opportunities to gain expertise in modern parasitology through its instructional and research components. The program offers a three-tiered curriculum which includes (1) a basic course introducing concepts of parasitology, while emphasizing parasites of importance to human and animal health, (2) advanced courses in molecular parasitology, pathogenesis, immunoparasitology, and other specialized disciplines, and (3) weekly journal clubs, research "focus" groups and seminars covering contemporary research topics. Trainees are required to take a formal course in research ethics designed as an introduction to issues surrounding the ethical conduct of research, attend lectures in the UW Global Health Seminar Series and present their research annually in the Parasitology Seminar program. Research training will consist of opportunities to investigate cellular, biochemical, immunological, or molecular aspects of parasite-host associations in any of 11 trainer laboratories. A wide range of parasite models are available for study including those of major importance to health in the tropics: malaria, trypanosomiasis, schistosomiasis, filariasis and ascariasis. Participating faculty have outstanding training records and well-funded programs covering diverse research areas such as vector biology, parasite immunology, biochemistry and gene regulation of metabolic pathways and parasite development, microbe-insect and microbe-mollusc symbioses, and neurobiology. Support is requested for five years to support four (4) predoctoral trainees per year. Exceptionally qualified trainees will be selected from a nationally competitive pool of applicants by the CMP training committee-of-the-whole. Selection will be based on scholastic excellence, recommendations, prior research experience and their commitment to careers in parasitological research. The duration of CMP training support for students will be from 2 to 3 years. Plans are described to encourage applications from and support of underrepresented minority students. Outstanding training facilities will be provided through individual investigator labs, departmental shared resources and outstanding campus-wide facilities including the Biotron, Biotechnology Center, Center for Genomic Studies, Integrated Microscopy Resource, and AAALAC-approved animal care facilities.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Institutional National Research Service Award (T32)
Project #
5T32AI007414-20
Application #
8301654
Study Section
Microbiology and Infectious Diseases B Subcommittee (MID)
Program Officer
Mcsweegan, Edward
Project Start
1992-07-01
Project End
2014-07-31
Budget Start
2012-08-01
Budget End
2014-07-31
Support Year
20
Fiscal Year
2012
Total Cost
$133,727
Indirect Cost
$8,714
Name
University of Wisconsin Madison
Department
Pathology
Type
Schools of Veterinary Medicine
DUNS #
161202122
City
Madison
State
WI
Country
United States
Zip Code
53715
Peterson, Nathan A; Anderson, Tavis K; Yoshino, Timothy P (2013) In silico analysis of the fucosylation-associated genome of the human blood fluke Schistosoma mansoni: cloning and characterization of the fucosyltransferase multigene family. PLoS One 8:e63299
Peterson, Nathan A; Anderson, Tavis K; Wu, Xiao-Jun et al. (2013) In silico analysis of the fucosylation-associated genome of the human blood fluke Schistosoma mansoni: cloning and characterization of the enzymes involved in GDP-L-fucose synthesis and Golgi import. Parasit Vectors 6:201
Erickson, Sara M; Thomsen, Edward K; Keven, John B et al. (2013) Mosquito-parasite interactions can shape filariasis transmission dynamics and impact elimination programs. PLoS Negl Trop Dis 7:e2433
Keating, Julie A; Bhattacharya, Dipankar; Rund, Samuel S C et al. (2013) Mosquito protein kinase G phosphorylates flavivirus NS5 and alters flight behavior in aedes aegypti and anopheles gambiae. Vector Borne Zoonotic Dis 13:590-600
Keating, Julie A; Bhattacharya, Dipankar; Lim, Pei-Yin et al. (2013) West Nile virus methyltransferase domain interacts with protein kinase G. Virol J 10:242
Silverman, Jason S; Muratore, Katherine A; Bangs, James D (2013) Characterization of the late endosomal ESCRT machinery in Trypanosoma brucei. Traffic 14:1078-90
Payne, Amanda J; Neal, Lori M; Knoll, Laura J (2013) Fusidic acid is an effective treatment against Toxoplasma gondii and Listeria monocytogenes in vitro, but not in mice. Parasitol Res 112:3859-63
Keating, Julie A; Striker, Rob (2012) Phosphorylation events during viral infections provide potential therapeutic targets. Rev Med Virol 22:166-81
Lim, Pei-Yin; Keating, Julie A; Hoover, Spencer et al. (2011) A thiopurine drug inhibits West Nile virus production in cell culture, but not in mice. PLoS One 6:e26697
Payne, T Matthew; Payne, Amanda J; Knoll, Laura J (2011) A Toxoplasma gondii mutant highlights the importance of translational regulation in the apicoplast during animal infection. Mol Microbiol 82:1204-16

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