This program, presently in its 20th year of funding, supports training of predoctoral (5) and postdoctoral (3) fellows in the biology of pathogenic microorganisms and their interaction with the human host. Preceptors on this training grant work on bacteria, viruses, and parasites that cause important human diseases and on the host immune response against these infectious agents. The principal focus is on the interaction of these microbes with the host and the processes whereby these interactions lead to disease. A central tenet for training is that trainees require exposure to broad, interdisciplinary areas of science to investigate the complex interactions between microbes and their hosts. Trainees are provided with conceptual and experimental foundations in microbiology, biochemistry, molecular biology, genetics, cell biology, genomics, proteomics, chemical biology, and computational biology. Faculty preceptors (28 at present) derive from 5 academic departments, 4 research institutes, and 3 clinical departments, providing a broad base of interdisciplinary research expertise. Preceptors in this program are highly collaborative and interactive, affording trainees exposure to a wide array of methods and approaches to problems in pathogenic microbiology. Trainees are selected by a committee of faculty preceptors from a highly competitive pool of applicants using clearly defined criteria. Successful applicants report research findings at least annually at a department seminar and receive feedback and critiques from multiple faculty members. The program tracks the progress of trainees both during and after their support by the training fellowship. Mentors and trainees provide an annual report describing progress on the research project and on overall professional advancement. An important new component of training entails a yearlong series of Career Development Meetings that allow both pre- and postdoctoral trainees to learn about a variety of career options in science and to develop essential networks of contacts for entering such disciplines. A Steering Committee evaluates the success of the program on an ongoing basis and suggests alterations or improvements as necessary. The program has been very successful in attracting and supporting women and minorities and continues to set a high priority on training members of groups that are traditionally underrepresented in science. Program support is provided by the institution in the form of administrative positions and fellowships for predoctoral students during the early years of their graduate program and by an additional trainee stipend. This training program has evolved significantly since its initiation, adding a large number of new preceptors and greatly increasing the representation of cutting edge methodologies and novel approaches relevant to understanding how microorganisms cause disease.

Public Health Relevance

This program supports the scientific training and professional development of 5 predoctoral and 3 postdoctoral trainees in the field of microbial pathogenesis with an emphasis on the interaction of infectious microbes with the human host. The training is highly interdisciplinary, involving exposure of trainees to multiple basic scientific disciplines, nd focuses on research in pathogenic bacteria, viruses, and parasites and the host immune response against them.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Institutional National Research Service Award (T32)
Project #
5T32AI007472-22
Application #
9086191
Study Section
Microbiology and Infectious Diseases B Subcommittee (MID)
Program Officer
Robbins, Christiane M
Project Start
1995-09-01
Project End
2020-08-31
Budget Start
2016-09-01
Budget End
2017-08-31
Support Year
22
Fiscal Year
2016
Total Cost
Indirect Cost
Name
Oregon Health and Science University
Department
Microbiology/Immun/Virology
Type
Schools of Medicine
DUNS #
096997515
City
Portland
State
OR
Country
United States
Zip Code
97239
Healy, Laura D; Rigg, Rachel A; Griffin, John H et al. (2018) Regulation of immune cell signaling by activated protein C. J Leukoc Biol :
Hessell, Ann J; Shapiro, Mariya B; Powell, Rebecca et al. (2018) Reduced cell-associated DNA and improved viral control in macaques following passive transfer of a single anti-V2 monoclonal antibody and repeated SHIV challenges. J Virol :
Kleven, Mark D; Jue, Shall; Enns, Caroline A (2018) Transferrin Receptors TfR1 and TfR2 Bind Transferrin through Differing Mechanisms. Biochemistry 57:1552-1559
Balasubramanian, Preetha; Williams, Constance; Shapiro, Mariya B et al. (2018) Functional Antibody Response Against V1V2 and V3 of HIV gp120 in the VAX003 and VAX004 Vaccine Trials. Sci Rep 8:542
Kleven, Mark D; Gomes, Michelle M; Wortham, Aaron M et al. (2018) Ultrafiltered recombinant AAV8 vector can be safely administered in vivo and efficiently transduces liver. PLoS One 13:e0194728
Birch, Cierra A; Davis, Madison J; Mbengi, Lea et al. (2017) Exploring the Amino Acid Residue Requirements of the RNA Polymerase (RNAP) ? Subunit C-Terminal Domain for Productive Interaction between Spx and RNAP of Bacillus subtilis. J Bacteriol 199:
Gardell, Jennifer L; Parker, David C (2017) CD40L is transferred to antigen-presenting B cells during delivery of T-cell help. Eur J Immunol 47:41-50
Messenheimer, David J; Jensen, Shawn M; Afentoulis, Michael E et al. (2017) Timing of PD-1 Blockade Is Critical to Effective Combination Immunotherapy with Anti-OX40. Clin Cancer Res 23:6165-6177
Pryke, Kara M; Abraham, Jinu; Sali, Tina M et al. (2017) A Novel Agonist of the TRIF Pathway Induces a Cellular State Refractory to Replication of Zika, Chikungunya, and Dengue Viruses. MBio 8:
Hirsch, Alec J; Smith, Jessica L; Haese, Nicole N et al. (2017) Zika Virus infection of rhesus macaques leads to viral persistence in multiple tissues. PLoS Pathog 13:e1006219

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