This training program is designed to prepare young scientists for independent careers in immunological research. The need for bright, thoroughly trained investigators in this area is great: diseases of autoimmunity, congenital and acquired immunodeficiency, and lymphoid neoplasms are among the most significant and perplexing causes of morbidity today. Research at the level of cellular and molecular mechanisms of host defense is also critical for elucidating and preventing the immunologic complications of bone marrow and solid organ transplantation and immune responses to gene therapy. Trainees (predoctoral and postdoctoral (M.D. or Ph.D.) fellows) are mentored by one of 16 program faculty (M.D., M.D./Ph.D., or Ph.D.) with primary or joint appointments in the Department of Immunology at Baylor College of Medicine, whose research programs address diverse areas of modern immunology, including lymphocyte differentiation, antigen receptor gene rearrangement and expression, peptide-MHC interaction, lymphocyte activation and apoptosis, immune responses to HIV, gene therapy, hematopoeitic stem cell biology, adhesion molecules in leukocyte trafficking and effector function, and cyotokines. Support for three predoctoral and three postdoctoral trainees (including an M.D. fellow) is requested. Predoctoral trainees are selected primarily from among students who have matriculated into the immunology graduate program and chosen one of the training faculty as their thesis mentor. Students who have entered the laboratories of participating faculty through other programs may also be considered. These trainees complete a core curriculum in basic and advanced areas of immunology and in modern cell and molecular biology. Postdoctoral trainees are selected from highly qualified Ph.D. or M.D. applicants to individual training faculty. In addition to faculty guidance of research training and career development, postdoctoral trainees may take advanced immunology courses.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Institutional National Research Service Award (T32)
Project #
5T32AI007495-08
Application #
6607732
Study Section
Special Emphasis Panel (ZAI1-NBS-I (M2))
Program Officer
Prograis, Lawrence J
Project Start
1996-05-01
Project End
2006-06-30
Budget Start
2003-07-01
Budget End
2004-06-30
Support Year
8
Fiscal Year
2003
Total Cost
$263,359
Indirect Cost
Name
Baylor College of Medicine
Department
Pathology
Type
Schools of Medicine
DUNS #
051113330
City
Houston
State
TX
Country
United States
Zip Code
77030
Weiderhold, Kimberly N; Fadri-Moskwik, Maria; Pan, Jing et al. (2016) Dynamic Phosphorylation of NudC by Aurora B in Cytokinesis. PLoS One 11:e0153455
Luo, Min; Jeong, Mira; Sun, Deqiang et al. (2015) Long non-coding RNAs control hematopoietic stem cell function. Cell Stem Cell 16:426-38
Sun, Deqiang; Luo, Min; Jeong, Mira et al. (2014) Epigenomic profiling of young and aged HSCs reveals concerted changes during aging that reinforce self-renewal. Cell Stem Cell 14:673-88
Challen, Grant A; Sun, Deqiang; Mayle, Allison et al. (2014) Dnmt3a and Dnmt3b have overlapping and distinct functions in hematopoietic stem cells. Cell Stem Cell 15:350-364
Kurata, Shoichiro (2014) Peptidoglycan recognition proteins in Drosophila immunity. Dev Comp Immunol 42:36-41
Deeraksa, A; Pan, J; Sha, Y et al. (2013) Plk1 is upregulated in androgen-insensitive prostate cancer cells and its inhibition leads to necroptosis. Oncogene 32:2973-83
Zohren, Fabian; Souroullas, George P; Luo, Min et al. (2012) The transcription factor Lyl-1 regulates lymphoid specification and the maintenance of early T lineage progenitors. Nat Immunol 13:761-9
Fadri-Moskwik, Maria; Weiderhold, Kimberly N; Deeraksa, Arpaporn et al. (2012) Aurora B is regulated by acetylation/deacetylation during mitosis in prostate cancer cells. FASEB J 26:4057-67
Wang, Xiaohong; Li, Ju-Pi; Kuo, Hui-Kai et al. (2012) Down-regulation of B cell receptor signaling by hematopoietic progenitor kinase 1 (HPK1)-mediated phosphorylation and ubiquitination of activated B cell linker protein (BLNK). J Biol Chem 287:11037-48
Shahi, Payam; Seethammagari, Mamatha R; Valdez, Joseph M et al. (2011) Wnt and Notch pathways have interrelated opposing roles on prostate progenitor cell proliferation and differentiation. Stem Cells 29:678-88

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