This is a competitive renewal, for years 16 to 20, of an institutional HIV/AIDS training grant. This training grant serves as the focal point for providing high quality training for advanced pre- and post-doctoral candidates who wish to pursue independent careers in HIV/AIDS-related topics. The program will offer broad training in modern biology including virological, immunological, biochemical, genetic and molecular approaches. AIDS-related research in this institute conforms to the principle that successful AIDS research requires multiple investigators pursuing closely related issues in AIDS. This training grant thus represents a platform for training and research by 16 faculty from four basic science, and two clinical Departments: Microbiology and Immunology, Genetics, Pathology, Biochemistry, Pediatrics and Medicine. Fourteen of the faculty are bench researchers, one is epidemiologist and one is a behavioral researcher. All training faculty of this program are members of the Einstein-Montefiore Center For AIDS Research, which provides centralized, essential core facilities required for AIDS research such as Virology, Flow cytometry, Animal Biohazard, Immunology and Clinical cores. Our predoctoral training program operates within the guidelines of the Sue Golding Graduate Division, featuring a centralized recruitment program and a well coordinated admissions process. This training program offers a core of basic courses followed by specialized courses in Virology, Microbial Pathogenesis and Immunology supplemented with journal clubs, work-in-progress meetings and seminars by outside experts for both pre- and postdoctoral trainees. An essential element is the intensive research program within each laboratory with close supervision throughout. Our program also includes training in specialized instrumentation and new technologies as needed for the specific research project: Flow cytometry, Hybridoma, Transgenic Mouse, Gene Knockout and Stem Cell Technology, X-ray Crystallography and Molecular Modeling, Peptide Synthesis &Protein Sequencing, Proteomics, Epigenomics, Gene arrays as well as routine DNA synthesis and sequencing. In the renewal application, featuring a recently expanded HIV/AIDS faculty, an augmented support from CFAR and a close interaction with the global AIDS program, we will pursue an integrated approach to HIV and opportunistic infections research with a major emphasis on molecular studies of HIV/AIDS and two major opportunistic pathogens (M. tuberculosis and C. neoformans) including development of chemotherapeutics, vaccine and immune therapies and murine models to study the pathogenesis of AIDS.

Public Health Relevance

This is an institutional training grant, which aims to train future scientists. Two broad categories of training are proposed: one leads to a doctorate degree and the second is for those who already have a doctorate degree. The individuals will train in a rich environment with experienced, accomplished scientists doing cutting edge AIDS research using modern biomedical facilities and will learn to conduct high quality research. The training is expected to generate mature scientists who would contribute to reducing the burden of AIDS disease.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Institutional National Research Service Award (T32)
Project #
5T32AI007501-19
Application #
8500093
Study Section
Acquired Immunodeficiency Syndrome Research Review Committee (AIDS)
Program Officer
Sharma, Opendra K
Project Start
1995-06-01
Project End
2015-07-31
Budget Start
2013-08-01
Budget End
2014-07-31
Support Year
19
Fiscal Year
2013
Total Cost
$260,868
Indirect Cost
$15,768
Name
Albert Einstein College of Medicine
Department
Microbiology/Immun/Virology
Type
Schools of Medicine
DUNS #
110521739
City
Bronx
State
NY
Country
United States
Zip Code
10461
Jaureguiberry-Bravo, Matias; Lopez, Lillie; Berman, Joan W (2018) Frontline Science: Buprenorphine decreases CCL2-mediated migration of CD14+ CD16+ monocytes. J Leukoc Biol 104:1049-1059
Kuniholm, Mark H; Liang, Hua; Anastos, Kathryn et al. (2017) Association of a 3' untranslated region polymorphism in proprotein convertase subtilisin/kexin type 9 with HIV viral load and CD4+ levels in HIV/hepatitis C virus coinfected women. AIDS 31:2483-2492
Flerin, Nina C; Chen, Huabiao; Glover, Tynisha D et al. (2017) T-Cell Receptor (TCR) Clonotype-Specific Differences in Inhibitory Activity of HIV-1 Cytotoxic T-Cell Clones Is Not Mediated by TCR Alone. J Virol 91:
Kuniholm, Mark H; Liang, Hua; Anastos, Kathryn et al. (2017) Association of a 3' Untranslated Region Polymorphism in PCSK9 with HIV Viral Load and CD4+ Levels in HIV/Hepatitis C Virus Co-Infected Women. AIDS :
Chen, Nan-Yu; Zhou, Lihong; Gane, Paul J et al. (2016) HIV-1 capsid is involved in post-nuclear entry steps. Retrovirology 13:28
La Porte, Annalena; Cano, Jennifer; Wu, Xuhong et al. (2016) An Essential Role of INI1/hSNF5 Chromatin Remodeling Protein in HIV-1 Posttranscriptional Events and Gag/Gag-Pol Stability. J Virol 90:9889-9904
Jaureguiberry-Bravo, Matias; Wilson, Rebecca; Carvallo, Loreto et al. (2016) Opioids and Opioid Maintenance Therapies: Their Impact on Monocyte-Mediated HIV Neuropathogenesis. Curr HIV Res 14:417-430
Olsen, Aaron; Chen, Yong; Ji, Qingzhou et al. (2016) Targeting Mycobacterium tuberculosis Tumor Necrosis Factor Alpha-Downregulating Genes for the Development of Antituberculous Vaccines. MBio 7:
Thenin-Houssier, Suzie; de Vera, Ian Mitchelle S; Pedro-Rosa, Laura et al. (2016) Ebselen, a Small-Molecule Capsid Inhibitor of HIV-1 Replication. Antimicrob Agents Chemother 60:2195-208
Bhattacharya, Akash; Wang, Zhonghua; White, Tommy et al. (2016) Effects of T592 phosphomimetic mutations on tetramer stability and dNTPase activity of SAMHD1 can not explain the retroviral restriction defect. Sci Rep 6:31353

Showing the most recent 10 out of 73 publications