The prevalence of allergic and immunological disorders has been steadily increasing in the pediatric population with more than 15% of children affected. However, the number of physicians both treating and investigating immunologic and allergic responses in children remains disproportionately small. Recent advances in our understanding of the immune system, along with the emergence of powerful yet complex research technologies in molecular biology, human genetics and immunobiology have created fertile ground for advancement of understanding of immunological mechanisms but also make it essential for trainees in the fields of allergy, immunology and rheumatology to undergo rigorous training in basic immunology in a cutting edge environment. Such training will prepare young physicians and Ph.D. scientists to advance our knowledge of these diseases through basic research, clinical research and the implementation of novel therapeutic strategies. Equally important, such training will prepare a cadre of physician scientists who will train the next generation of physician scientists. The proposed training program will seek the most talented and committed young pediatricians as well as Ph.D. scientists (all postdoctoral) committed to clinically applicable immunology research and will provide them with intensive training experience in research in an unparalleled environment. All training will be within the general discipline of Immunology, with a broad representation of immunology topics (allergy, tolerance, T cell function, B cell function, autoimmunity, immune regulation and immune deficiency) covered by a diverse and internationally-recognized faculty in the Harvard Medical School community. A three year training experience is proposed;physicians will receive a year one year of clinical training (not funded by this grant) prior to entering the program. The program will fund 9 trainees per year, each with M.D. , M.D., Ph.D. or Ph.D. credentials.

Public Health Relevance

Allergies and immune system diseases are becoming increasingly common, especially in children. Treatment options are limited so research to identify both the roots of allergy and possible treatments is critical. This Training Program seeks to recruit talented young pediatricians and Ph.D. scientists committed to translational research and to prepare them for careers as productive researchers in the area of pediatric immunology.

National Institute of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
Institutional National Research Service Award (T32)
Project #
Application #
Study Section
Allergy & Clinical Immunology-1 (AITC)
Program Officer
Prograis, Lawrence J
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Children's Hospital Boston
United States
Zip Code
Orzalli, Megan H; Kagan, Jonathan C (2017) Apoptosis and Necroptosis as Host Defense Strategies to Prevent Viral Infection. Trends Cell Biol 27:800-809
Burton, Oliver T; Stranks, Amanda J; Tamayo, Jaciel M et al. (2017) A humanized mouse model of anaphylactic peanut allergy. J Allergy Clin Immunol 139:314-322.e9
Burton, O T; Medina Tamayo, J; Stranks, A J et al. (2017) IgE promotes type 2 innate lymphoid cells in murine food allergy. Clin Exp Allergy :
Biggs, Catherine M; Keles, Sevgi; Chatila, Talal A (2017) DOCK8 deficiency: Insights into pathophysiology, clinical features and management. Clin Immunol 181:75-82
Bai, Ming; Grieshaber-Bouyer, Ricardo; Wang, Junxia et al. (2017) CD177 modulates human neutrophil migration through activation-mediated integrin and chemoreceptor regulation. Blood 130:2092-2100
Cohen, Ezra M; Morley-Fletcher, Alessio; Mehta, Darshan H et al. (2017) A systematic review of psychosocial therapies for children with rheumatic diseases. Pediatr Rheumatol Online J 15:6
Platt, Craig D; Massaad, Michel J; Cangemi, Brittney et al. (2017) Janus kinase 3 deficiency caused by a homozygous synonymous exonic mutation that creates a dominant splice site. J Allergy Clin Immunol 140:268-271.e6
Yee, Christina S; Massaad, Michel J; Bainter, Wayne et al. (2016) Recurrent viral infections associated with a homozygous CORO1A mutation that disrupts oligomerization and cytoskeletal association. J Allergy Clin Immunol 137:879-88.e2
Cohen, Ezra; Sundel, Robert (2016) Kawasaki Disease at 50 Years. JAMA Pediatr 170:1093-1099
Sobh, Ali; Crestani, Elena; Cangemi, Brittney et al. (2016) Autoimmune lymphoproliferative syndrome caused by a homozygous FasL mutation that disrupts FasL assembly. J Allergy Clin Immunol 137:324-327.e2

Showing the most recent 10 out of 87 publications