Vaccination is one of the most cost-effective approaches in preventive medicine. Over the past 3 decades, new techniques in recombinant DNA and biotechnology have offered unprecedented opportunities for developing new vaccines. Many training opportunities exist to prepare individuals for research in immunology, molecular genetics, infectious diseases, and other specific aspects of vaccine development, but few training programs offer broad exposure to both laboratory and clinical trial aspects of vaccinology as a cohesive discipline. For the past 37 years, the Center for Vaccine Development of the University of Maryland School of Medicine has been involved in all aspects of vaccine development, from basic laboratory studies involving genetic construction of recombinant vaccines to Phase 1 through Phase 4 clinical trials. We propose to continue a formal training program in which individuals with M.D. or Ph.D. (or equivalent) degrees can be prepared specifically for careers in vaccinology, either to pursue basic vaccine development research or to conduct investigative clinical trials and translational research. Two new trainees will join the training program in each of the five years and training for each trainee will ensue fr 3 (sometimes 4) years. Support only for years 1 and 2 is requested in this proposal;support for the 3rd and possible 4th years will come from fellowships, research grants, or other sources. The Training Program in Vaccinology offers to all trainees a broad exposure to both the laboratory and clinical trial phases of vaccinology. Beyond this broad exposure, the program has two tracks to provide each trainee with intensive experience in either the laboratory aspects or the clinical phases of vaccinology, depending upon which track they choose. The Laboratory Track allows the training of basic scientists and physician-scientists in vaccine development laboratory research, particularly in the use of recombinant DNA technology to prepare new vaccine candidates and the use of modern immunological techniques to study the human humoral and cellular immune response to vaccines. The Clinical Track trains clinicians (internists or pediatricians) in trial design, protocol development, regulatory and ethical clearances, performance of clinical trials, data analysis and clinical translational research. The ultimate goal of this training program is to provide a well-trained cadre of individuals who can fully exploit the unprecedented opportunities now available in vaccine development.

Public Health Relevance

Vaccines developed during the past few decades have been able to protect children and adults from infectious diseases that caused suffering and death in past generations. The tools of modern science allow new vaccines to be designed and tested and made available to protect the health of our population. We propose to continue our Training Program that trains scientists in how to develop new vaccines and doctors in how to test the candidate new vaccines in step-wise fashion to the point where we are sure of their safety and their ability to protect the public against infectious diseases that were not previously preventable.

Agency
National Institute of Health (NIH)
Type
Institutional National Research Service Award (T32)
Project #
5T32AI007524-17
Application #
8689877
Study Section
Microbiology and Infectious Diseases Research Committee (MID)
Program Officer
Robbins, Christiane M
Project Start
Project End
Budget Start
Budget End
Support Year
17
Fiscal Year
2014
Total Cost
Indirect Cost
Name
University of Maryland Baltimore
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
City
Baltimore
State
MD
Country
United States
Zip Code
21201
Fresnay, Stephanie; McArthur, Monica A; Magder, Laurence et al. (2016) Salmonella Typhi-specific multifunctional CD8+ T cells play a dominant role in protection from typhoid fever in humans. J Transl Med 14:62
Cohee, Lauren M; Kalilani-Phiri, Linda; Mawindo, Patricia et al. (2016) Parasite dynamics in the peripheral blood and the placenta during pregnancy-associated malaria infection. Malar J 15:483
Santiago, Araceli E; Mann, Barbara J; Qin, Aiping et al. (2015) Characterization of Francisella tularensis Schu S4 defined mutants as live-attenuated vaccine candidates. Pathog Dis 73:ftv036
Heine, Shannon J; Franco-Mahecha, Olga L; Chen, Xiaotong et al. (2015) Shigella IpaB and IpaD displayed on L. lactis bacterium-like particles induce protective immunity in adult and infant mice. Immunol Cell Biol 93:641-52
Boudová, Sarah; Divala, Titus; Mawindo, Patricia et al. (2015) The prevalence of malaria at first antenatal visit in Blantyre, Malawi declined following a universal bed net campaign. Malar J 14:422
Toapanta, Franklin R; Bernal, Paula J; Fresnay, Stephanie et al. (2015) Oral Wild-Type Salmonella Typhi Challenge Induces Activation of Circulating Monocytes and Dendritic Cells in Individuals Who Develop Typhoid Disease. PLoS Negl Trop Dis 9:e0003837
McArthur, Monica A; Fresnay, Stephanie; Magder, Laurence S et al. (2015) Activation of Salmonella Typhi-specific regulatory T cells in typhoid disease in a wild-type S. Typhi challenge model. PLoS Pathog 11:e1004914
Walldorf, Jenny A; Cohee, Lauren M; Coalson, Jenna E et al. (2015) School-Age Children Are a Reservoir of Malaria Infection in Malawi. PLoS One 10:e0134061
Boyd, Mary Adetinuke; Tennant, Sharon M; Saague, Venant A et al. (2014) Serum bactericidal assays to evaluate typhoidal and nontyphoidal Salmonella vaccines. Clin Vaccine Immunol 21:712-21
Cohee, Lauren M; Kalilani-Phiri, Linda; Boudova, Sarah et al. (2014) Submicroscopic malaria infection during pregnancy and the impact of intermittent preventive treatment. Malar J 13:274

Showing the most recent 10 out of 27 publications