Support for a third funding cycle of the predoctoral training Program entitled """"""""Molecular and Cell Biology of Infectious Diseases"""""""". The training Program will be based in the Department of Molecular Genetics and Microbiology at Stony Brook University, 8 of whose faculty are proposed mentors. With an additional 12 outstanding faculty mentors from other University Departments, and nearby Brookhaven National Laboratories, the Program will train predoctoral students for a productive career in infectious disease research. Training will consist of lecture and laboratory courses in Genetics, Biochemistry, Molecular Biology, Cell Biology, Immunology, Microbial Pathogenesis and Scientific Ethics that will prepare students for thesis research. Students who show the most promise, based on their undergraduate academic performance and their achievements In graduate course work, laboratory rotations and qualifying exams, will be admitted to the Program beginning in the third year of graduate school for a 2- to 3-year period. All faculty mentors have a common interest in teaching and investigating the pathogenesis of infectious diseases at the molecular and cellular levels. All faculty mentors in the Program have individual NIH grants or other forms of support. The areas of thesis research training available to students include: a) bacterial pathogenesis;b) fungal virulence mechanisms;c) viral pathogenesis and replication;d) regulation of pathogen gene and protein expression;e) control of viral packaging and capsid assembly;f) development of diagnostics, drugs and vaccines against pathogens, g) innate immune responses to pathogens, and h) pathogenesis of Category A agents. The Program is overseen by a Director and Executive Committee and has a strong record of collaboration among faculty and students. The Program includes a robust mechanism for evaluating and improving all aspects of the training environment and for tracking the success of previous trainees for a period of up to 10 years. Nine of 10 trainees that have completed the Program since its inception remain in research/teaching positions and trainees generated 28 research publications during the period of support. The application requests support for 5 years, with 4 trainees requested in years 1-2, and 5 in years 3-5.

Public Health Relevance

The MCBID Program will provide high-quality training in research and career development for predoctoral scientists. The ultimate goal is to foster the development of the future leaders in the field of infectious disease research.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Institutional National Research Service Award (T32)
Project #
5T32AI007539-15
Application #
8494507
Study Section
Microbiology and Infectious Diseases B Subcommittee (MID)
Program Officer
Robbins, Christiane M
Project Start
1998-09-30
Project End
2014-08-31
Budget Start
2013-09-01
Budget End
2014-08-31
Support Year
15
Fiscal Year
2013
Total Cost
$175,673
Indirect Cost
$10,733
Name
State University New York Stony Brook
Department
Genetics
Type
Schools of Medicine
DUNS #
804878247
City
Stony Brook
State
NY
Country
United States
Zip Code
11794
Singh, Ashutosh; Del Poeta, Maurizio (2016) Sphingolipidomics: An Important Mechanistic Tool for Studying Fungal Pathogens. Front Microbiol 7:501
Parrino, Salvatore M; Si, Haoyu; Naseem, Shamoon et al. (2016) cAMP-independent signal pathways stimulate hyphal morphogenesis in Candida albicans. Mol Microbiol :
Cieniewicz, Brandon; Santana, Alexis L; Minkah, Nana et al. (2016) Interplay of Murine Gammaherpesvirus 68 with NF-kappaB Signaling of the Host. Front Microbiol 7:1202
Bridges, Rebecca G; Sohn, Sook-Young; Wright, Jordan et al. (2016) The Adenovirus E4-ORF3 Protein Stimulates SUMOylation of General Transcription Factor TFII-I to Direct Proteasomal Degradation. MBio 7:e02184-15
Chahales, Peter; Hoffman, Paul S; Thanassi, David G (2016) Nitazoxanide Inhibits Pilus Biogenesis by Interfering with Folding of the Usher Protein in the Outer Membrane. Antimicrob Agents Chemother 60:2028-38
Schoberle, Taylor J; Chung, Lawton K; McPhee, Joseph B et al. (2016) Uncovering an Important Role for YopJ in the Inhibition of Caspase-1 in Activated Macrophages and Promoting Yersinia pseudotuberculosis Virulence. Infect Immun 84:1062-72
Chung, Lawton K; Bliska, James B (2016) Yersinia versus host immunity: how a pathogen evades or triggers a protective response. Curr Opin Microbiol 29:56-62
Chung, Lawton K; Park, Yong Hwan; Zheng, Yueting et al. (2016) The Yersinia Virulence Factor YopM Hijacks Host Kinases to Inhibit Type III Effector-Triggered Activation of the Pyrin Inflammasome. Cell Host Microbe 20:296-306
Cieniewicz, Brandon; Dong, Qiwen; Li, Gang et al. (2015) Murine Gammaherpesvirus 68 Pathogenesis Is Independent of Caspase-1 and Caspase-11 in Mice and Impairs Interleukin-1β Production upon Extrinsic Stimulation in Culture. J Virol 89:6562-74
Zhang, Yue; Tam, Jason W; Mena, Patricio et al. (2015) CCR2+ Inflammatory Dendritic Cells and Translocation of Antigen by Type III Secretion Are Required for the Exceptionally Large CD8+ T Cell Response to the Protective YopE69-77 Epitope during Yersinia Infection. PLoS Pathog 11:e1005167

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