The proposed training program will continue to provide predoctoral trainees with a solid academic background in molecular pathogenesis, with a particular emphasis on host-pathogen interactions. Training will include relevant course work, regularly scheduled seminars and journal clubs, and rigorous laboratory training with the goal of preparing our students for careers in research in pathogenesis. Faculty recruitment efforts have resulted in the formation of a critical mass of established investigators in the broad area of microbial pathogenesis, and with it an integrated training program for predoctoral students in host-pathogen interactions has been established. In addition to their common research interests, many of the faculty have evidence of collaborative interactions. Faculty research interests encompass areas including regulation of virulence gene expression, host-pathogen interactions, molecular immunology and immune defense, molecular virology and parasitology. The program currently consists of 9 faculty, all of whom are current NIH grant holders and who, as a group, have had a substantial training history and enjoy national and international recognition in their respective fields. The training faculty represents a broad range of departmental affiliations, including the Departments of Microbiology and Medicine at Boston University School of Medicine, and the Department of Molecular and Cell Biology in the Boston University Goldman School of Dental Medicine. We expect the members of the training faculty to increase over the next several years as recruiting for the National Emerging Infections Disease Laboratory at Boston University School of Medicine begins. The training opportunities for predoctoral fellows in this program will also increase during this same period of time. The major goal of the program will be to 1) recruit and enroll students of this highest quality, including underrepresented minorities;2) provide these trainees with a multidisciplinary background in molecular pathogenesis coupled with intensive laboratory training in a particular research topic;3) to teach the trainees critical thinking skills and to ask relevant and feasible research questions;4) to instill these trainees with a sense of ethical behavior;5) to help develop effective written and oral communication skills among the trainees;and 6) to facilitate collaborative interactions among both students and faculty of the host-pathogen interaction training program.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Institutional National Research Service Award (T32)
Project #
5T32AI007642-09
Application #
8101970
Study Section
Microbiology and Infectious Diseases B Subcommittee (MID)
Program Officer
Mcsweegan, Edward
Project Start
2000-09-30
Project End
2013-08-31
Budget Start
2011-09-01
Budget End
2012-08-31
Support Year
9
Fiscal Year
2011
Total Cost
$86,264
Indirect Cost
Name
Boston University
Department
Microbiology/Immun/Virology
Type
Schools of Medicine
DUNS #
604483045
City
Boston
State
MA
Country
United States
Zip Code
02118
Finn, Peter R; Gerst, Kyle; Lake, Allison et al. (2017) Decisions to Attend and Drink at Party Events: The Effects of Incentives and Disincentives and Lifetime Alcohol and Antisocial Problems. Alcohol Clin Exp Res 41:1622-1629
Gerst, Kyle R; Gunn, Rachel L; Finn, Peter R (2017) Delay Discounting of Losses in Alcohol Use Disorders and Antisocial Psychopathology: Effects of a Working Memory Load. Alcohol Clin Exp Res 41:1768-1774
Dai, Junyi; Gunn, Rachel L; Gerst, Kyle R et al. (2016) A random utility model of delay discounting and its application to people with externalizing psychopathology. Psychol Assess 28:1198-1206
Finn, Peter R; Gunn, Rachel L; Gerst, Kyle R (2015) The Effects of a Working Memory Load on Delay Discounting in Those with Externalizing Psychopathology. Clin Psychol Sci 3:202-214
Bushkin, G Guy; Motari, Edwin; Carpentieri, Andrea et al. (2013) Evidence for a structural role for acid-fast lipids in oocyst walls of Cryptosporidium, Toxoplasma, and Eimeria. MBio 4:e00387-13
Tremaglio, Chadene Z; Noton, Sarah L; Deflube, Laure R et al. (2013) Respiratory syncytial virus polymerase can initiate transcription from position 3 of the leader promoter. J Virol 87:3196-207
Samuelson, John; Bushkin, G Guy; Chatterjee, Aparajita et al. (2013) Strategies to discover the structural components of cyst and oocyst walls. Eukaryot Cell 12:1578-87
Noton, Sarah L; Deflube, Laure R; Tremaglio, Chadene Z et al. (2012) The respiratory syncytial virus polymerase has multiple RNA synthesis activities at the promoter. PLoS Pathog 8:e1002980
Bushkin, G Guy; Motari, Edwin; Magnelli, Paula et al. (2012) ýý-1,3-glucan, which can be targeted by drugs, forms a trabecular scaffold in the oocyst walls of Toxoplasma and Eimeria. MBio 3:
Bobova, Lyuba; Finn, Peter R; Rickert, Martin E et al. (2009) Disinhibitory psychopathology and delay discounting in alcohol dependence: personality and cognitive correlates. Exp Clin Psychopharmacol 17:51-61

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