HIV-1 remains one of the most important infectious causes of global morbidity and mortality. Recent research successes make this an exciting time in HIV/AIDS research - but continued progress will require interdisciplinary, collaborative efforts by highly trained, expert scientists. The goal of this proposal is to prepare young scientists for that role, and to train the next generation of HIV/AIDS researchers. The trainees will be equipped with a broad range of skills and knowledge including virology, molecular biology and immunology as well as training in mentoring, scientific writing, cutting edge research techniques, and other issues important to their career development. Since the previous competitive renewal of this application, we have broadened the research opportunities available, integrated this training program with the University of Rochester (UR)'s new Developmental Center for AIDS Research (DCFAR) and its Clinical &Translational Science Institute (CTSI), added new HIV/AIDS-specific courses, and designed an innovative peer/near-peer evaluation process to enhance trainee career development. We have also added an External Advisory Board to assist with oversight of this program. The program has 4 specific objectives. First: To develop an interactive, productive and exciting interdisciplinary environment in which predoctoral trainees obtain an outstanding education in HIV/AIDS research. This will be achieved by integrating faculty from multiple departments and disciplines. Second: To leverage resources and opportunities created by the UR's new Developmental Center for AIDS Research (DCFAR) and its Clinical &Translational Science Institute (CTSI). This will be achieved by accessing new courses, seminars and cutting-edge scientific core facilities. Third: To provide an enriched training and learning environment for students, with structured seminar programs, distinguished extramural speakers, career development activities, HIV/AIDS-specific courses, an innovative peer/near-peer evaluation process to support trainee career development, enhanced training in the responsible conduct of research, and opportunities for training in mentoring. Students will also be trained in scientific writing, with emphasis on manuscripts and grant applications. Fourth: To foster communication among trainees and faculty through the programs outlined above. This will exploit the intimate environment provided at the UR School of Medicine and Dentistry, where all the participating faculty and trainees work together in the same physical space, under a single roof. Overall, the program will provide outstanding training opportunities in three major emphasis areas: (i) viral replication, RNA biology and reverse transcription, (ii) viral immunology and vaccine biology, and (iii) viral pathogenesis (with emphasis on neuroAIDS).

Public Health Relevance

This program seeks to train predoctoral students for careers as outstanding research scientists in the field of HIV/AIDS. To do this, trainees will be equipped with a broad range of skills and knowledge including virology, molecular biology and immunology as well as training in mentoring, career development, cutting edge scientific techniques, and other issues important to their scientific future.

National Institute of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
Institutional National Research Service Award (T32)
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Acquired Immunodeficiency Syndrome Research Review Committee (AIDS)
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Sharma, Opendra K
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University of Rochester
Schools of Dentistry
United States
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Ortiz-Riano, Emilio; Ngo, Nhi; Devito, Stefanie et al. (2014) Inhibition of arenavirus by A3, a pyrimidine biosynthesis inhibitor. J Virol 88:878-89
Singh, Meera V; Davidson, Donna C; Jackson, Joseph W et al. (2014) Characterization of platelet-monocyte complexes in HIV-1-infected individuals: possible role in HIV-associated neuroinflammation. J Immunol 192:4674-84
Domm, William; Brewer, Matthew; Baker, Steven F et al. (2014) Use of bacteriophage particles displaying influenza virus hemagglutinin for the detection of hemagglutination-inhibition antibodies. J Virol Methods 197:47-50
Lifson, Mark A; Basu Roy, Dhrubajyoti; Miller, Benjamin L (2014) Enhancing the detection limit of nanoscale biosensors via topographically selective functionalization. Anal Chem 86:1016-22
Marker, Daniel F; Tremblay, Marie-Eve; Puccini, Jenna M et al. (2013) The new small-molecule mixed-lineage kinase 3 inhibitor URMC-099 is neuroprotective and anti-inflammatory in models of human immunodeficiency virus-associated neurocognitive disorders. J Neurosci 33:9998-10010
Easterhoff, David; Ontiveros, Fernando; Brooks, Lauren R et al. (2013) Semen-derived enhancer of viral infection (SEVI) binds bacteria, enhances bacterial phagocytosis by macrophages, and can protect against vaginal infection by a sexually transmitted bacterial pathogen. Antimicrob Agents Chemother 57:2443-50
Easterhoff, David; DiMaio, John T M; Liyanage, Wathsala et al. (2013) Fluorescence detection of cationic amyloid fibrils in human semen. Bioorg Med Chem Lett 23:5199-202
Davidson, Donna C; Jackson, Joseph W; Maggirwar, Sanjay B (2013) Targeting platelet-derived soluble CD40 ligand: a new treatment strategy for HIV-associated neuroinflammation? J Neuroinflammation 10:144
Amie, Sarah M; Bambara, Robert A; Kim, Baek (2013) GTP is the primary activator of the anti-HIV restriction factor SAMHD1. J Biol Chem 288:25001-6
Van Cor-Hosmer, Sarah K; Daddacha, Waaqo; Kelly, Z et al. (2012) The impact of molecular manipulation in residue 114 of human immunodeficiency virus type-1 reverse transcriptase on dNTP substrate binding and viral replication. Virology 422:393-401

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