The Duke University Graduate Program in Immunology proposes a continuation of its Basic Immunology Training Program. The main objective of the Training Program is to select talented predoctoral candidates and to prepare them, through formal coursework, seminars and independent research, for outstanding and productive research careers in basic immunology. The training faculty consists of 23 immunologists who hold primary or secondary appointments in the Department of Immunology. This faculty provides trainees with opportunities for rigorous training in a range of areas of contemporary immunologic research, for example: mechanisms of lymphocyte development and function, including lineage determination, V(D)J recombination, class switch recombination, somatic hypermutation, cell signaling, effector cell differentiation, lymphocyte homeostasis, immunological memory and immunological tolerance;mechanisms of innate immunity and inflammation, including macrophage, dendritic cell, mast cell and complement function;mechanisms of host defense against bacterial, viral and fungal pathogens;autoimmunity;anti-tumor immunity;and vaccine development. Funds are sought to support the training of four predoctoral students per year. A selections committee will choose the most outstanding second and third year predoctoral trainees in the Graduate Program in Immunology for support by the Training Program. Special emphasis will be placed on the recruitment and selection of outstanding underrepresented minority trainees. A carefully crafted core curriculum will provide trainees with superb grounding in basic immunology, biochemistry, cell biology, molecular biology and genetics. Trainees will receive formal training in research ethics to insure that they will conduct their research with the highest standards of academic integrity. Trainees will also be provided a range of career development opportunities so that they are best equipped to parlay their training into productive and rewarding career paths.

Public Health Relevance

The Basic Immunology Training Program will teach the next generation of US researchers the critical skills they will need to perform outstanding basic immunologic research. Future discoveries by these researchers will be absolutely essential for our continued progress in the fights against infectious diseases, cancer, autoimmune diseases, and immunodeficiency diseases.

National Institute of Health (NIH)
Institutional National Research Service Award (T32)
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Transplantation Biology &Immunology-2 (AITC)
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Prograis, Lawrence J
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Duke University
Schools of Medicine
United States
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Lai, Anne Y; Watanabe, Akiko; O'Brien, Tommy et al. (2009) Pertussis toxin-sensitive G proteins regulate lymphoid lineage specification in multipotent hematopoietic progenitors. Blood 113:5757-64
Kikuchi, Kazu; Kasai, Hirotake; Watanabe, Akiko et al. (2008) IL-7 specifies B cell fate at the common lymphoid progenitor to pre-proB transition stage by maintaining early B cell factor expression. J Immunol 181:383-92
Hudson, Lori L; Louise Markert, M; Devlin, Blythe H et al. (2007) Human T cell reconstitution in DiGeorge syndrome and HIV-1 infection. Semin Immunol 19:297-309
Lai, Anne Y; Kondo, Motonari (2007) Identification of a bone marrow precursor of the earliest thymocytes in adult mouse. Proc Natl Acad Sci U S A 104:6311-6
Draper, David W; Bethea, Heather N; He, You-Wen (2006) Toll-like receptor 2-dependent and -independent activation of macrophages by group B streptococci. Immunol Lett 102:202-14
Lai, Anne Y; Kondo, Motonari (2006) Asymmetrical lymphoid and myeloid lineage commitment in multipotent hematopoietic progenitors. J Exp Med 203:1867-73
Hsu, Chia-Lin; King-Fleischman, Angela G; Lai, Anne Y et al. (2006) Antagonistic effect of CCAAT enhancer-binding protein-alpha and Pax5 in myeloid or lymphoid lineage choice in common lymphoid progenitors. Proc Natl Acad Sci U S A 103:672-7
Lai, Anne Y; Lin, Simon M; Kondo, Motonari (2005) Heterogeneity of Flt3-expressing multipotent progenitors in mouse bone marrow. J Immunol 175:5016-23
Jackson, Annette; Kondilis, Hrisavgi D; Khor, Bernard et al. (2005) Regulation of T cell receptor beta allelic exclusion at a level beyond accessibility. Nat Immunol 6:189-97
Kikuchi, Kazu; Lai, Anne Y; Hsu, Chia-Lin et al. (2005) IL-7 receptor signaling is necessary for stage transition in adult B cell development through up-regulation of EBF. J Exp Med 201:1197-203

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