The emergence of Severe Acute Respiratory Syndrome (SARS), potential for a highly pathogenic influenza pandemic, and sobering reality of the 2001 anthrax attacks emphasize the danger to human health posed by infectious organisms, both natural and man-made. An effective response to infectious threats requires individuals well versed in infectious disease biology and control, as well as biodefense preparedness. Such preparedness was demonstrated by Wadsworth Center's anthrax testing initiative in 2001, as well as its subsequent SARS and influenza programs. A training program for predoctoral and postdoctoral fellows in the laboratory sciences, with an epidemiology enrichment, is proposed to meet this need for scientists with expertise in emerging infections and biodefense sciences. The goal of this program is to provide multi-disciplinary training combining basic and applied research to produce: (1) doctoral graduates with backgrounds in emerging infectious diseases and biodefense;and (2) postdoctoral fellows who can become independent scientists developing integrated research programs in emerging infections and biodefense. Ten well-funded mentors and five associate mentors are drawn from the Wadsworth Center and the Office of Science of the New York State Department of Health, through their academic appointments within the School of Public Health, University at Albany, SUNY. This unique training environment combines fundamental research with infectious disease outbreak and biodefense response. The training program's key components are based on the existing curriculum of the Departments of Biomedical Sciences and Epidemiology. Didactic components include grounding in biochemistry, cell biology, microbiology, virology, molecular genetics, microbial pathogenesis, immunology, and infectious disease epidemiology with a focus on the biological basis of public health and disease transmission. A set of courses on Emerging Infections and Biodefense Sciences introduces biosafety procedures, BSL3 pathogen containment, pathogen detection, and bioterrorism event and response modeling. Fellows participate in clinically relevant laboratory rotations and colloquia, and journal clubs covering advanced topics and the current literature. An emerging infections research seminar series builds on existing Wadsworth Center and Department of Health seminar programs. The steering and advisory committees, and the existing University at Albany, School of Public Health academic structures, ensure that high-quality applicants enter this specialized program and that both pre- and postdoctoral students become productive scientists in this research area.
The emergence of Severe Acute Respiratory Syndrome (SARS), potential for a highly pathogenic influenza pandemic, and sobering reality of the 2001 anthrax attacks emphasize the danger to human health posed by infectious organisms, both natural and man-made. This application proposes to train pre- and postdoctoral scientists to combat such threats to the nation's public health.
|Sully, Erin K; Whaley, Kevin; Bohorova, Natasha et al. (2014) A tripartite cocktail of chimeric monoclonal antibodies passively protects mice against ricin, staphylococcal enterotoxin B and Clostridium perfringens epsilon toxin. Toxicon 92:36-41|
|Fitzgerald, Devon M; Bonocora, Richard P; Wade, Joseph T (2014) Comprehensive mapping of the Escherichia coli flagellar regulatory network. PLoS Genet 10:e1004649|
|Yermakova, Anastasiya; Klokk, Tove Irene; Cole, Richard et al. (2014) Antibody-mediated inhibition of ricin toxin retrograde transport. MBio 5:e00995|
|Aliota, Matthew T; Dupuis 2nd, Alan P; Wilczek, Michael P et al. (2014) The prevalence of zoonotic tick-borne pathogens in Ixodes scapularis collected in the Hudson Valley, New York State. Vector Borne Zoonotic Dis 14:245-50|
|Sully, Erin K; Whaley, Kevin J; Bohorova, Natasha et al. (2014) Chimeric plantibody passively protects mice against aerosolized ricin challenge. Clin Vaccine Immunol 21:777-82|
|Chen, Hui; Zhou, Bing; Brecher, Matthew et al. (2013) S-adenosyl-homocysteine is a weakly bound inhibitor for a flaviviral methyltransferase. PLoS One 8:e76900|
|Yermakova, Anastasiya; Mantis, Nicholas J (2013) Neutralizing activity and protective immunity to ricin toxin conferred by B subunit (RTB)-specific Fab fragments. Toxicon 72:29-34|
|Bonocora, Richard P; Fitzgerald, Devon M; Stringer, Anne M et al. (2013) Non-canonical protein-DNA interactions identified by ChIP are not artifacts. BMC Genomics 14:254|
|Amarasinghe, Jayaleka J; D'Hondt, Rebecca E; Waters, Christopher M et al. (2013) Exposure of Salmonella enterica Serovar typhimurium to a protective monoclonal IgA triggers exopolysaccharide production via a diguanylate cyclase-dependent pathway. Infect Immun 81:653-64|
|Yermakova, Anastasiya; Mantis, Nicholas J (2011) Protective immunity to ricin toxin conferred by antibodies against the toxin's binding subunit (RTB). Vaccine 29:7925-35|
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