The principal objective of the T32 program "Infectious Disease Training in Clinical Investigation" is to provide mentored research training that will prepare physician investigators for successful and productive academic careers in Infectious Diseases. The rationale for this program is that this field continues to witness enormous growth and new challenges due to emerging and re-emerging infections, both within the U.S. and globally, for which a new generation of well-trained clinical investigators is needed. To accomplish this goal, an interdisciplinary faculty from the University of Minnesota Medical School (and its Departments of Medicine, Pediatrics, and Microbiology), School of Public Health, College of Pharmacy, College of Dentistry, and College of Veterinary Medicine, as well as the Minnesota Department of Health, has been engaged in this training program. These faculty trainers have expertise in one or more of eight core topic areas relevant to emerging and re-emerging Infections: 1) HIV/AIDS, 2) Invasive Bacterial Infections, 3) Antimicrobial Resistance, 4) Immunodeficiency/Vaccines, 5) International and Immigrant Health, 6) Bioterrorism, 7) Foodborne Infections, and 8) Zoonoses. The program is designed for physicians who have completed an internal medicine or pediatrics residency program, plus at least one year of clinical training in adult or pediatric Infectious Diseases. It will support two years of focused, closely mentored research training in clinical and/or epidemiological research, as well as completion of the requirements for a Master of Public Health in Epidemiology or Master of Science in Clinical Research degree. The program will accept approximately two new trainees annually, giving a total of approximately four trainees in the program at any time.

Public Health Relevance

The relevance of this training program lies in the increasing threat to public health posed by emerging and re-emerging infections, as exemplified by community-associated methicillin-resistant Staphylococcus aureus, the HIV/AIDS epidemic, extensively-drug-resistant tuberculosis, E. coli 0157:H7 outbreaks, and pandemic and avian influenza. This has created a need for additional expert clinical researchers who can discover the causes of, and find remedies for these growing threats.

National Institute of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
Institutional National Research Service Award (T32)
Project #
Application #
Study Section
Microbiology and Infectious Diseases B Subcommittee (MID)
Program Officer
Robbins, Christiane M
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of Minnesota Twin Cities
Internal Medicine/Medicine
Schools of Medicine
United States
Zip Code
Leuck, Anne-Marie; Johnson, James R; Dunny, Gary M (2014) A widely used in vitro biofilm assay has questionable clinical significance for enterococcal endocarditis. PLoS One 9:e107282
Rolfes, Melissa A; Hullsiek, Kathy Huppler; Rhein, Joshua et al. (2014) The effect of therapeutic lumbar punctures on acute mortality from cryptococcal meningitis. Clin Infect Dis 59:1607-14
Frosch, Anne E P; Ondigo, Bartholomew N; Ayodo, George A et al. (2014) Decline in childhood iron deficiency after interruption of malaria transmission in highland Kenya. Am J Clin Nutr 100:968-73
Boulware, David R; Rolfes, Melissa A; Rajasingham, Radha et al. (2014) Multisite validation of cryptococcal antigen lateral flow assay and quantification by laser thermal contrast. Emerg Infect Dis 20:45-53
Boulware, David R; Meya, David B; Muzoora, Conrad et al. (2014) Timing of antiretroviral therapy after diagnosis of cryptococcal meningitis. N Engl J Med 370:2487-98
Bahr, Nathan C; Wallace, James; Frosch, Anne E P et al. (2014) Unmasking Cryptococcal Meningitis Immune Reconstitution Inflammatory Syndrome due to Granulocyte Colony-Stimulating Factor Use in a Patient with a Poorly Differentiated Germ Cell Neoplasm. Case Rep Oncol 7:1-5
Leuck, Anne-Marie; Rothenberger, Meghan K; Green, Jaime S (2014) Fungemia due to Lachancea fermentati: a case report. BMC Infect Dis 14:250
Borewicz, Klaudyna; Pragman, Alexa A; Kim, Hyeun Bum et al. (2013) Longitudinal analysis of the lung microbiome in lung transplantation. FEMS Microbiol Lett 339:57-65
Musubire, Abdu K; Boulware, David R; Meya, David B et al. (2013) Diagnosis and Management of Cryptococcal Relapse. J AIDS Clin Res Suppl 3:
Bakeera-Kitaka, S; Conesa-Botella, A; Dhabangi, A et al. (2011) Tuberculosis in human immunodeficiency virus infected Ugandan children starting on antiretroviral therapy. Int J Tuberc Lung Dis 15:1082-6

Showing the most recent 10 out of 26 publications