The Molecular Basis of Infectious Disease (MBID) is a research training program consisting of 18 faculty mentors from four Houston educational institutions: the University of Texas Health Science Center at Houston, Baylor College of Medicine, the Texas A&M University Institute for Biosciences and Technology, and the University of Houston, College Park. In this initial application, training support is requested for four Ph.D. students and four undergraduate summer research students. The overall purpose of the MBID training program is to provide the trainees 1) an optimal environment for training new scientists in the latest concepts and techniques in microbiological research; 2) a better understanding of current challenges in clinical infectious diseases; and 3) the knowledge and tools to 'bridge the gap' between basic research and clinical applications. The basis of this training grant is the Molecular Basis of Infectious Disease group, which was first formed in 1996. MBID has developed into highly interactive group of over 100 faculty, postdoctoral fellows, graduate students, and staff from the Houston area whose primary interest is in the molecular pathogenesis of bacterial infections. The 16 faculty members that form the core of this training grant have a record of high research productivity and extensive collaborations. They have mentored over 200 predoctoral and postdoctoral trainees over the past ten years and currently are mentoring 25 Ph.D. students and 29 postdoctoral fellows. Nineteen current predoctoral trainees are eligible for an NRSA. The training program will be based on strong core curricula, 10 advanced courses in pathogenesis, an intensive and interactive research experience, monthly MBID meetings and retreats, seminars and journal clubs, and experience in translational research and clinical infectious diseases. A network of universities serving underrepresented minorities has been established to aid in the recruitment of promising undergraduate students into the summer research program and the MBID Ph.D. program. A goal of the planned activities supported by this training grant is to provide predoctoral microbiology candidates additional knowledge in clinical infectious diseases and translational research, thereby promoting the redirection of research toward the more rapid resolution of important infectious disease problems. ? ?

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Institutional National Research Service Award (T32)
Project #
5T32AI055449-03
Application #
7274211
Study Section
Microbiology and Infectious Diseases B Subcommittee (MID)
Program Officer
Mcsweegan, Edward
Project Start
2005-09-15
Project End
2010-07-31
Budget Start
2007-08-01
Budget End
2008-07-31
Support Year
3
Fiscal Year
2007
Total Cost
$96,298
Indirect Cost
Name
University of Texas Health Science Center Houston
Department
Pathology
Type
Schools of Medicine
DUNS #
800771594
City
Houston
State
TX
Country
United States
Zip Code
77225
Oyaro, Micah O; Plants-Paris, Kimberly; Bishoff, Dayna et al. (2018) High rate of Clostridium difficile among young adults presenting with diarrhea at two hospitals in Kenya. Int J Infect Dis 74:24-28
Okyere, Ama; Bishoff, Dayna; Oyaro, Micah O et al. (2018) Analysis of Fish Commonly Sold in Local Supermarkets Reveals the Presence of Pathogenic and Multidrug-Resistant Bacterial Communities. Microbiol Insights 11:1178636118786925
Hunter, Robert L; Actor, Jefrey K; Hwang, Shen-An et al. (2018) Pathogenesis and Animal Models of Post-Primary (Bronchogenic) Tuberculosis, A Review. Pathogens 7:
Darkoh, Charles; Deaton, Magdalena; DuPont, Herbert L (2017) Nonantimicrobial drug targets for Clostridium difficile infections. Future Microbiol 12:975-985
Darkoh, Charles; DuPont, Herbert L (2017) The accessory gene regulator-1 as a therapeutic target for C. difficile infections. Expert Opin Ther Targets 21:451-453
Vesely, Elisa M; Williams, Robert B; Konopka, James B et al. (2017) N-Acetylglucosamine Metabolism Promotes Survival of Candida albicans in the Phagosome. mSphere 2:
Whitaker, Neal; Berry, Trista M; Rosenthal, Nathan et al. (2016) Chimeric Coupling Proteins Mediate Transfer of Heterologous Type IV Effectors through the Escherichia coli pKM101-Encoded Conjugation Machine. J Bacteriol 198:2701-18
Danhof, Heather A; Vylkova, Slavena; Vesely, Elisa M et al. (2016) Robust Extracellular pH Modulation by Candida albicans during Growth in Carboxylic Acids. MBio 7:
Stojanoski, Vlatko; Adamski, Carolyn J; Hu, Liya et al. (2016) Removal of the Side Chain at the Active-Site Serine by a Glycine Substitution Increases the Stability of a Wide Range of Serine ?-Lactamases by Relieving Steric Strain. Biochemistry 55:2479-90
Stojanoski, Vlatko; Sankaran, Banumathi; Prasad, B V Venkataram et al. (2016) Structure of the catalytic domain of the colistin resistance enzyme MCR-1. BMC Biol 14:81

Showing the most recent 10 out of 42 publications