The Molecular Basis of Infectious Disease (MBID) research training program is centered on 16 faculty mentors from three Houston educational institutions: the University, of Texas Health Science Center at Houston, Baylor College of Medicine, and the Texas A&M University Institute for Biosciences and Technology. In this renewal application, continued training support is requested for three Ph.D. students and eight undergraduate summer research students. The overall purpose of the MBID training program is to provide trainees 1) an optimal environment for training new scientists in the latest concepts and techniques in microbiological research;2) a better understanding of current challenges in clinical infectious diseases;and 3) the knowledge and tools to 'bridge the gap'between basic research and clinical applications. The basis of this training grant is the Molecular Basis of Infectious Disease group, which was first formed in 1996. MBID has developed into highly interactive group of over 400 faculty, postdoctoral fellows, graduate students, and staff from the Houston area whose primary interest is in the molecular pathogenesis of bacterial infections. The 16 faculty members that form the core of this training grant have a record of high research productivity and extensive collaborations. They have mentored 178 predoctoral and postdoctoral trainees during the past ten years, and currently are mentoring 22 Ph.D. students and 25 postdoctoral fellows. The training program is based on a strong core curriculum, intensive and interactive research experiences, monthly MBID meetings, annual retreats, weekly seminars and journal clubs, and training in translational research and clinical infectious diseases. A summer research program has been established to aid in the recruitment of promising undergraduate students (and in particular underrepresented minority [URM] trainees) into careers in infectious disease research. During the initial grant period, 3 of 7 predoctoral trainees and 10 of 31 summer undergraduate trainees were URM students, thus promising continued success in this objective during the coming grant period.

Public Health Relevance

The major goal of this ongoing, successful training grant is to provide microbiology trainees additional knowledge in clinical infectious diseases and translational research, thereby directing research toward the more rapid resolution of important infectious disease problems. In addition, the program will continue to recruit highly qualified underrepresented minority students, increasing the proportion of underrepresented minority scientists performing research at the cutting edge of the microbiology/infectious disease interface.

National Institute of Health (NIH)
Institutional National Research Service Award (T32)
Project #
Application #
Study Section
Microbiology and Infectious Diseases Research Committee (MID)
Program Officer
Robbins, Christiane M
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of Texas Health Science Center Houston
Schools of Medicine
United States
Zip Code
Latorre, Mauricio; Galloway-Peña, Jessica; Roh, Jung Hyeob et al. (2014) Enterococcus faecalis reconfigures its transcriptional regulatory network activation at different copper levels. Metallomics 6:572-81
Bakhru, Pearl; Sirisaengtaksin, Natalie; Soudani, Emily et al. (2014) BCG vaccine mediated reduction in the MHC-II expression of macrophages and dendritic cells is reversed by activation of Toll-like receptors 7 and 9. Cell Immunol 287:53-61
Tiller, George R; Garsin, Danielle A (2014) The SKPO-1 peroxidase functions in the hypodermis to protect Caenorhabditis elegans from bacterial infection. Genetics 197:515-26
Reardon-Robinson, Melissa E; Wu, Chenggang; Mishra, Arunima et al. (2014) Pilus hijacking by a bacterial coaggregation factor critical for oral biofilm development. Proc Natl Acad Sci U S A 111:3835-40
Pflughoeft, Kathryn J; Swick, Michelle C; Engler, David A et al. (2014) Modulation of the Bacillus anthracis secretome by the immune inhibitor A1 protease. J Bacteriol 196:424-35
Pflughoeft, Kathryn J; Sumby, Paul; Koehler, Theresa M (2011) Bacillus anthracis sin locus and regulation of secreted proteases. J Bacteriol 193:631-9
Galloway-Pena, Jessica R; Rice, Louis B; Murray, Barbara E (2011) Analysis of PBP5 of early U.S. isolates of Enterococcus faecium: sequence variation alone does not explain increasing ampicillin resistance over time. Antimicrob Agents Chemother 55:3272-7
Darkoh, Charles; Kaplan, Heidi B; Dupont, Herbert L (2011) Harnessing the glucosyltransferase activities of Clostridium difficile for functional studies of toxins A and B. J Clin Microbiol 49:2933-41
Galloway-Pena, Jessica R; Bourgogne, Agathe; Qin, Xiang et al. (2011) Diversity of the fsr-gelE region of the Enterococcus faecalis genome but conservation in strains with partial deletions of the fsr operon. Appl Environ Microbiol 77:442-51
Banta, Lois M; Kerr, Jennifer E; Cascales, Eric et al. (2011) An Agrobacterium VirB10 mutation conferring a type IV secretion system gating defect. J Bacteriol 193:2566-74

Showing the most recent 10 out of 16 publications