The Objectives of the UCSF Microbial Pathogenesis and Host Defense (MPHD) program are to provide world class training and research for graduate students and postdoctoral fellows at UCSF by creating a coherent and cohesive community comprised of diverse world class laboratories studying all aspects of microbial pathogenesis. World-wide, infectious diseases are a leading cause of death. The study of microbial pathogenesis is a rapidly advancing area of research, with unprecedented opportunity to influence health worldwide through the development of new preventative, therapeutic, and diagnostic strategies. The MPHD program at UCSF offers a world class training program that currently is comprised of 27 faculty training 59 graduate students, and 128 postdoctoral fellows. 5 faculty members were newly recruited to UCSF to join the program in the past 6 years. Areas of active research include the pathogenesis of malaria, TB, shistosomiasis, HIV, fungal pathogens, and gram negative and gram positive infections. The MPHD program is designed to provide a solid background in genetics, cell biology, molecular biology, and mammalian tissue and organ biology as well as thorough training in microbial pathogenesis. The Interdisciplinary nature of this training is enhanced by the affiliation ofthe MPHD Program with the UCSF Biomedical Sciences Program (BMS) and Program in Biomedical Sciences (PIBS), interdisciplinary graduate programs through which graduate students enter the MPHD program. The MPHD training program includes (i) a weekly seminar series comprised of outside invited speakers, research-in-progress talks from students and postdocs in the program (ii) a graduate level course entitled "Molecular Mechanisms of Microbial Pathogenesis" offered every other spring as an elective for grandate students that can be audited by postdoctoral fellows (iii) a yearly bay area wide day symposium with student, postdoc, and faculty speakers, an outside invited keynote speaker, and a poster session that is offered free of charge (iv) Microbial pathogenesis sessions at the two main yearly graduate program retreats (Biomedical Science Program and Program in Biological Sciences) (v) support for 4 graduate students and 2 postdocs through this T32 training grant (vii) a website with up to date information about the MPHD program and its activities as well as links to other relevant websites.

Public Health Relevance

Infectious disease is a leading cause of death, despite availability of antibiotics, vaccines, and advanced hygienic standards. Strategies for the prevention, treatment, and control of infectious diseases will require fundamental bench and translational research. The study of microbial pathogenesis is a rapidly advancing area of research, with unprecedented opportunity to influence health worldwide.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Institutional National Research Service Award (T32)
Project #
5T32AI060537-10
Application #
8462195
Study Section
Microbiology and Infectious Diseases B Subcommittee (MID)
Program Officer
Robbins, Christiane M
Project Start
2004-08-01
Project End
2014-07-31
Budget Start
2013-08-01
Budget End
2014-07-31
Support Year
10
Fiscal Year
2013
Total Cost
$288,506
Indirect Cost
$17,365
Name
University of California San Francisco
Department
Microbiology/Immun/Virology
Type
Schools of Medicine
DUNS #
094878337
City
San Francisco
State
CA
Country
United States
Zip Code
94143
Baccarella, Alyssa; Huang, Brian W; Fontana, Mary F et al. (2014) Loss of Toll-like receptor 7 alters cytokine production and protects against experimental cerebral malaria. Malar J 13:354
Webster, Brian; Wissing, Silke; Herker, Eva et al. (2013) Rapid intracellular competition between hepatitis C viral genomes as a result of mitosis. J Virol 87:581-96
Ruelas, Debbie S; Greene, Warner C (2013) An integrated overview of HIV-1 latency. Cell 155:519-29
Beyhan, Sinem; Gutierrez, Matias; Voorhies, Mark et al. (2013) A temperature-responsive network links cell shape and virulence traits in a primary fungal pathogen. PLoS Biol 11:e1001614
Nobile, Clarissa J; Fox, Emily P; Nett, Jeniel E et al. (2012) A recently evolved transcriptional network controls biofilm development in Candida albicans. Cell 148:126-38
Quezada, Landys A Lopez; Sajid, Mohammed; Lim, Kee C et al. (2012) A blood fluke serine protease inhibitor regulates an endogenous larval elastase. J Biol Chem 287:7074-83
Elwell, Cherilyn A; Jiang, Shaobo; Kim, Jung Hwa et al. (2011) Chlamydia trachomatis co-opts GBF1 and CERT to acquire host sphingomyelin for distinct roles during intracellular development. PLoS Pathog 7:e1002198
Chun, Cheryl D; Brown, Jessica C S; Madhani, Hiten D (2011) A major role for capsule-independent phagocytosis-inhibitory mechanisms in mammalian infection by Cryptococcus neoformans. Cell Host Microbe 9:243-51
Gogol, Emily B; Rhodius, Virgil A; Papenfort, Kai et al. (2011) Small RNAs endow a transcriptional activator with essential repressor functions for single-tier control of a global stress regulon. Proc Natl Acad Sci U S A 108:12875-80
Quezada, Landys A Lopez; McKerrow, James H (2011) Schistosome serine protease inhibitors: parasite defense or homeostasis? An Acad Bras Cienc 83:663-72

Showing the most recent 10 out of 28 publications