The UCSF Microbial Pathogenesis and Host Defense (MPHD) program provides a comprehensive, world-class training plan to prepare graduate students and postdoctoral fellows for future careers in academics, industry, public health, or teaching. The MPHD program's primary goal is to train the next generation of leaders in this critically important field. Recent rapid advances in microbial pathogenesis, immunology, the genetics, genomics, and systems biology provide unprecedented opportunities to improve the health of mankind worldwide. The importance of training our next generation of scientific leaders to use these tools for innovative approaches has never been greater. Our program provides outstanding trainees with funded research opportunities in cutting edge, interdisciplinary scientific training environments. UCSF hosts an unusual number of world-class laboratories in each aspect of microbial pathogenesis, including bacterial, viral, fungal, parasitic, and innate immunity research programs. The faculty has an outstanding track record of creative and high profile research, excellent mentoring, and substantial research funding, and thus attracts outstanding trainees. Likewise, the MPHD program has catalyzed new scientific directions and broadened the training opportunities in microbial pathogenesis by bringing together laboratories with traditional expertise in the field with those from diverse scientific fields. Thus, a major objective of our research training program is to capitalize on the strengths of the UCSF research community to create an integrative program focused on issues in host-microbe interactions. As an interdepartmental and intercampus program at UCSF, the MPHD Program is open to all UCSF graduate students and postdoctoral fellows with an interest in microbial pathogenesis. The program integrates students, postdoctoral fellows, and faculty from diverse programs, expertise, and backgrounds by nourishing synergistic interactions and facilitating new approaches not otherwise possible. MPHD trainees are drawn from an elite pool of very highly qualified students and postdoctoral fellows. Outstanding institutional core facilities are availabl to accelerate application of new and emerging technologies. The strong tradition of openness and collaboration among UCSF laboratories and research groups allows trainees to easily access diverse expertise from multiple faculty. The program is comprised of the following program-specific components: a weekly seminar series, a yearly Bay Area-wide symposium, yearly graduate student elective courses in MPHD, and a postdoctoral mentoring program that augments the already high caliber of postdoctoral training by matching fellows with an additional mentor separate from their PI (the affiliated graduate students are already cross-mentored through their respective graduate programs). In this grant renewal, we request continuation of 4 pre-doctoral slots and 2 post-doctoral slots, to provide support at the same level as in prior years. This support will allow us to continue our history of training the next generation of leader in microbial pathogenesis who will work to reduce the worldwide burden of infectious disease.

Public Health Relevance

The application proposes to continue a highly successful training program, Microbial Pathogenesis and Host Defense, which was initiated 10 years ago. UCSF hosts world-class laboratories studying all disciplines of microbial pathogenesis, including bacteria, fungi, parasites, and viruses. Our central goal is to train the next generation of leader in microbial pathogenesis who will work to reduce the worldwide burden of infectious disease.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Institutional National Research Service Award (T32)
Project #
2T32AI060537-11
Application #
8742781
Study Section
Microbiology and Infectious Diseases B Subcommittee (MID)
Program Officer
Robbins, Christiane M
Project Start
2004-08-05
Project End
2019-07-31
Budget Start
2014-08-05
Budget End
2015-07-31
Support Year
11
Fiscal Year
2014
Total Cost
$306,758
Indirect Cost
$17,982
Name
University of California San Francisco
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
094878337
City
San Francisco
State
CA
Country
United States
Zip Code
94143
Baccarella, Alyssa; Huang, Brian W; Fontana, Mary F et al. (2014) Loss of Toll-like receptor 7 alters cytokine production and protects against experimental cerebral malaria. Malar J 13:354
Webster, Brian; Wissing, Silke; Herker, Eva et al. (2013) Rapid intracellular competition between hepatitis C viral genomes as a result of mitosis. J Virol 87:581-96
Ruelas, Debbie S; Greene, Warner C (2013) An integrated overview of HIV-1 latency. Cell 155:519-29
Beyhan, Sinem; Gutierrez, Matias; Voorhies, Mark et al. (2013) A temperature-responsive network links cell shape and virulence traits in a primary fungal pathogen. PLoS Biol 11:e1001614
Nobile, Clarissa J; Fox, Emily P; Nett, Jeniel E et al. (2012) A recently evolved transcriptional network controls biofilm development in Candida albicans. Cell 148:126-38
Quezada, Landys A Lopez; Sajid, Mohammed; Lim, Kee C et al. (2012) A blood fluke serine protease inhibitor regulates an endogenous larval elastase. J Biol Chem 287:7074-83
Elwell, Cherilyn A; Jiang, Shaobo; Kim, Jung Hwa et al. (2011) Chlamydia trachomatis co-opts GBF1 and CERT to acquire host sphingomyelin for distinct roles during intracellular development. PLoS Pathog 7:e1002198
Chun, Cheryl D; Brown, Jessica C S; Madhani, Hiten D (2011) A major role for capsule-independent phagocytosis-inhibitory mechanisms in mammalian infection by Cryptococcus neoformans. Cell Host Microbe 9:243-51
Gogol, Emily B; Rhodius, Virgil A; Papenfort, Kai et al. (2011) Small RNAs endow a transcriptional activator with essential repressor functions for single-tier control of a global stress regulon. Proc Natl Acad Sci U S A 108:12875-80
Quezada, Landys A Lopez; McKerrow, James H (2011) Schistosome serine protease inhibitors: parasite defense or homeostasis? An Acad Bras Cienc 83:663-72

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