The Center for Tropical and Emerging Global Diseases (CTEGD) of the University of Georgia proposes the continuation of support for its successful training program for biomedical investigators in the areas of bioinformatics, biochemistry, genetics, molecular biology, cell biology and immunology related to laboratory and field research on parasitic pathogens, their hosts and vectors. CTEGD is founded on the tenet that to achieve full impact scientists who study these diseases should be accomplished in their discipline, cooperate across disciplinary boundaries, and understand their research in the greater global context. Accordingly our educational concept is based on rigorous training that imparts broad understanding of the biosciences, in depth training in a focused area of research, and perspectives to appreciate the challenge parasitic diseases pose at the level of global medical and public health implementation. This training grant continues to draw on the breadth of training opportunities within the Departments of Cellular Biology, Infectious Diseases, Entomology, Microbiology, Food Science and Technology, Biochemistry and Molecular Biology and Genetics. The research programs of 19 well funded and highly experienced CTEGD faculty members provides training in many aspects of parasite biology and host/parasite relationships. The research systems available for study include malaria, intestinal protozoans, Chagas disease, African sleeping sickness, leishmaniasis, toxoplasmosis, Ichthyophthirius multifiliis, schistosomiasis, lymphatic filariasis, parasitoid insects and culicine, anopheline and ixodid vectors. Through courses, a seminar series (Journal Club and Research in Progress), broad-based lectureships, annual symposia, and unique overseas opportunities, trainees broaden their view of parasitology beyond their specific research focus. This includes in-depth discussions of responsible research practices at the bench and in the field. Funding is requested for 5 years to support 6 predoctoral and 3 post-doctoral trainees per year. Superior trainees will be selected competitively from a national pool of applicants based on scholastic records, recommendations, standardized testing, prior research experience and commitment to a scientific career in this field.

Public Health Relevance

Human and veterinary parasitic diseases are major scourges of much of the world, and training the next generation of scientists who will use today's and tomorrow's tools to tackle these diseases is of paramount importance. This Training Program not only trains quality trainees in cutting-edge research, it also broadens their perspectives so they are able to interface with translational and operational researchers to push forward both scientifically and in regard to public health measures around the globe

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Institutional National Research Service Award (T32)
Project #
5T32AI060546-10
Application #
8669709
Study Section
Microbiology and Infectious Diseases Research Committee (MID)
Program Officer
Robbins, Christiane M
Project Start
2004-08-01
Project End
2015-08-31
Budget Start
2014-09-01
Budget End
2015-08-31
Support Year
10
Fiscal Year
2014
Total Cost
Indirect Cost
Name
University of Georgia
Department
Public Health & Prev Medicine
Type
Organized Research Units
DUNS #
City
Athens
State
GA
Country
United States
Zip Code
30602
Szempruch, Anthony J; Sykes, Steven E; Kieft, Rudo et al. (2016) Extracellular Vesicles from Trypanosoma brucei Mediate Virulence Factor Transfer and Cause Host Anemia. Cell 164:246-57
Chen, Funing; Flaherty, Briana R; Cohen, Charli E et al. (2016) Direct detection of malaria infected red blood cells by surface enhanced Raman spectroscopy. Nanomedicine 12:1445-51
Rosenberg, Charles S; Zhang, Weibo; Bustamante, Juan M et al. (2016) Long-Term Immunity to Trypanosoma cruzi in the Absence of Immunodominant trans-Sialidase-Specific CD8+ T Cells. Infect Immun 84:2627-38
Flaherty, Briana R; Wang, Yuxiao; Trope, Edward C et al. (2015) The Stapled AKAP Disruptor Peptide STAD-2 Displays Antimalarial Activity through a PKA-Independent Mechanism. PLoS One 10:e0129239
Vinayak, Sumiti; Pawlowic, Mattie C; Sateriale, Adam et al. (2015) Genetic modification of the diarrhoeal pathogen Cryptosporidium parvum. Nature 523:477-80
King-Keller, Sharon; Moore, Christina A; Docampo, Roberto et al. (2015) Ca2+ Regulation of Trypanosoma brucei Phosphoinositide Phospholipase C. Eukaryot Cell 14:486-94
Borges-Pereira, Lucas; Budu, Alexandre; McKnight, Ciara A et al. (2015) Calcium Signaling throughout the Toxoplasma gondii Lytic Cycle: A STUDY USING GENETICALLY ENCODED CALCIUM INDICATORS. J Biol Chem 290:26914-26
Bullard, Whitney; Cliffe, Laura; Wang, Pengcheng et al. (2015) Base J glucosyltransferase does not regulate the sequence specificity of J synthesis in trypanosomatid telomeric DNA. Mol Biochem Parasitol 204:77-80
Hartley, Ashley N; Tarleton, Rick L (2015) Chemokine receptor 7 (CCR7)-expression and IFNγ production define vaccine-specific canine T-cell subsets. Vet Immunol Immunopathol 164:127-36
Lévêque, Maude F; Berry, Laurence; Cipriano, Michael J et al. (2015) Autophagy-Related Protein ATG8 Has a Noncanonical Function for Apicoplast Inheritance in Toxoplasma gondii. MBio 6:e01446-15

Showing the most recent 10 out of 35 publications