This application is a competitive renewal request for continuing support of four pre-doctoral trainees per year engaged in research using animal models of infectious diseases (AMID), which will be matched by two positions funded by UC Davis institutional support. The AMID Training Program, first funded in 2004, takes advantage of the extraordinary resources at UC Davis for research on animal models of infectious diseases, including the co-localization of the Graduate School, the Schools of Medicine and Veterinary Medicine, the California National Primate Research Center, the Mouse Biology Program, and the Center for Comparative Medicine, a unique training environment that arguably exists nowhere else in the world. During the first funding period, through this NIH grant and UC Davis matching support, we supported 23 students working under the supervision of 18 different faculty trainers. The success of the AMID Program is highlighted by the quality of the students and their accomplishments, the impact on collaborative research and student mentorship, research seminars, collaborative grants by participating faculty, and by our careful attention to teaching responsible conduct of research and promoting student diversity. The AMID Training Program has grown substantially since its inception, most notably by increases in faculty size, diversity, collaboration, and grant support;by increases in the size and quality of the student candidate pool;and by the addition of new courses and seminar series. The AMID Training Program will continue to be administered by Jay Solnick, MD, PhD (Director), with the assistance of Charles Bevins, MD, PhD (Associate Director), and an Executive Committee experienced in graduate education. The faculty trainers for the program will be 23 investigators at UC Davis, whose work uses animal models to better understand a broad range of viral, bacterial, and eukaryotic human pathogens. Students will be drawn from a pool of over 100 students in the graduate groups of Microbiology and Immunology, and an even larger number in related graduate groups. They will be matched with relevant faculty trainers and their progress will be closely monitored by the Program Director, Associate Director, and an Advisory Committee experienced in graduate education. Training will emphasize rigorous scientific research, oral and written scientific communication, and interaction with a broad range of scientists interested in animal models of human infectious diseases.

Public Health Relevance

Research conducted by these trainees will have broad impact on the understanding, management, and prevention of infectious disease, which is one of the most important aspects of human health.

National Institute of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
Institutional National Research Service Award (T32)
Project #
Application #
Study Section
Microbiology and Infectious Diseases Research Committee (MID)
Program Officer
Robbins, Christiane M
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of California Davis
Internal Medicine/Medicine
Schools of Medicine
United States
Zip Code
Byndloss, Mariana X; Olsan, Erin E; Rivera-Chávez, Fabian et al. (2017) Microbiota-activated PPAR-? signaling inhibits dysbiotic Enterobacteriaceae expansion. Science 357:570-575
Savage, Hannah P; Yenson, Vanessa M; Sawhney, Sanjam S et al. (2017) Blimp-1-dependent and -independent natural antibody production by B-1 and B-1-derived plasma cells. J Exp Med 214:2777-2794
Lee, Seung-Joo; Benoun, Joseph; Sheridan, Brian S et al. (2017) Dual Immunization with SseB/Flagellin Provides Enhanced Protection against Salmonella Infection Mediated by Circulating Memory Cells. J Immunol 199:1353-1361
Carden, Sarah E; Walker, Gregory T; Honeycutt, Jared et al. (2017) Pseudogenization of the Secreted Effector Gene sseI Confers Rapid Systemic Dissemination of S. Typhimurium ST313 within Migratory Dendritic Cells. Cell Host Microbe 21:182-194
Murphy, Kaitlin C; Whitehead, Jacklyn; Zhou, Dejie et al. (2017) Engineering fibrin hydrogels to promote the wound healing potential of mesenchymal stem cell spheroids. Acta Biomater 64:176-186
Ho, Steve S; Murphy, Kaitlin C; Binder, Bernard Y K et al. (2016) Increased Survival and Function of Mesenchymal Stem Cell Spheroids Entrapped in Instructive Alginate Hydrogels. Stem Cells Transl Med 5:773-81
Keestra-Gounder, A Marijke; Byndloss, Mariana X; Seyffert, Núbia et al. (2016) NOD1 and NOD2 signalling links ER stress with inflammation. Nature 532:394-7
Rivera-Chávez, Fabian; Zhang, Lillian F; Faber, Franziska et al. (2016) Depletion of Butyrate-Producing Clostridia from the Gut Microbiota Drives an Aerobic Luminal Expansion of Salmonella. Cell Host Microbe 19:443-54
Faber, Franziska; Tran, Lisa; Byndloss, Mariana X et al. (2016) Host-mediated sugar oxidation promotes post-antibiotic pathogen expansion. Nature 534:697-9
Rivera-Chávez, Fabian; Lopez, Christopher A; Zhang, Lillian F et al. (2016) Energy Taxis toward Host-Derived Nitrate Supports a Salmonella Pathogenicity Island 1-Independent Mechanism of Invasion. MBio 7:

Showing the most recent 10 out of 78 publications