The University of Pittsburgh's Pitt AIDS Research Training (PART) Program will be administered under the leadership of the Program Director, Dr. Todd Reinhart, with assistance from an internal steering committee and an external advisory committee. The current program has been training predoctoral students for four years and during this fifth year of training, we are seeking to renew the NIH support for the program. During this time we have trained or are continuing to train a total of 15 PhD students for periods of one to two years each. This proposal is for support to allow the PART Program to build upon the success of the first period of the award and continue to support the predoctoral training of HIV/AIDS researchers at the University of Pittsburgh. Rigorous training in both the process and content of HIV/AIDS research will be maintained and expanded. Continued efforts will be made to recruit and train the best and brightest students in the laboratories of our productive HIV/AIDS faculty members. These faculty members span multiple cross-cutting programs with appointments in mostly two departments: (1) the Department of Infectious Diseases &Microbiology in the Graduate School of Public Health;and (2) the Department of Microbiology &Molecular Genetics in the University of Pittsburgh School of Medicine. The majority of students will continue to be registered either in the IDM PhD program or in the Molecular Virology and Microbiology PhD program within the broader School of Medicine Interdisciplinary Biomedical Graduate Program. In the next training period, the PART Program will give specific attention to developing the leadership skills of PART trainees through the formal study of leadership theory and practice. Preparing the future generation of scientist requires not only an understanding of how to perform research, but the critical social contexts in which this occurs. This social context for these high-quality trainees will ultimately involve leadership positions and there is a tremendous gap in the extent to which researchers are being taught about leadership. With emphasis on high-quality research, with a foundation of excellent didactic coursework, and in a world-class HIV/AIDS research environment, PART trainees will be prepared for leadership roles at the postdoctoral and independent investigator levels.

Public Health Relevance

The HIV/AIDS epidemic continues and solid, innovative, and well-led research is required to continue to face this challenge. The PART Program will continue to train PhD level investigators in a multi-disciplinary environment so that they are prepared to perform and lead basic HIV/AIDS research and contribute to the fight against this infectious disease.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Institutional National Research Service Award (T32)
Project #
5T32AI065380-10
Application #
8663823
Study Section
Microbiology and Infectious Diseases Research Committee (MID)
Program Officer
Sharma, Opendra K
Project Start
2005-09-01
Project End
2015-07-31
Budget Start
2014-08-01
Budget End
2015-07-31
Support Year
10
Fiscal Year
2014
Total Cost
Indirect Cost
Name
University of Pittsburgh
Department
Internal Medicine/Medicine
Type
Schools of Public Health
DUNS #
City
Pittsburgh
State
PA
Country
United States
Zip Code
15213
Zaccard, C R; Rinaldo, C R; Mailliard, R B (2016) Linked in: immunologic membrane nanotube networks. J Leukoc Biol 100:81-94
Raehtz, Kevin; Pandrea, Ivona; Apetrei, Cristian (2016) The well-tempered SIV infection: Pathogenesis of SIV infection in natural hosts in the wild, with emphasis on virus transmission and early events post-infection that may contribute to protection from disease progression. Infect Genet Evol :
Smith, Steven J; Pauly, Gary T; Akram, Aamir et al. (2016) Rilpivirine and Doravirine Have Complementary Efficacies Against NNRTI-Resistant HIV-1 Mutants. J Acquir Immune Defic Syndr 72:485-91
Swan, Zachary D; Wonderlich, Elizabeth R; Barratt-Boyes, Simon M (2016) Macrophage accumulation in gut mucosa differentiates AIDS from chronic SIV infection in rhesus macaques. Eur J Immunol 46:446-54
Smith, Steven J; Pauly, Gary T; Akram, Aamir et al. (2016) Rilpivirine analogs potently inhibit drug-resistant HIV-1 mutants. Retrovirology 13:11
Hao, Xing Pei; Lucero, Carissa M; Turkbey, Baris et al. (2015) Experimental colitis in SIV-uninfected rhesus macaques recapitulates important features of pathogenic SIV infection. Nat Commun 6:8020
Zaccard, Colleen R; Watkins, Simon C; Kalinski, Pawel et al. (2015) CD40L induces functional tunneling nanotube networks exclusively in dendritic cells programmed by mediators of type 1 immunity. J Immunol 194:1047-56
He, Tianyu; Brocca-Cofano, Egidio; Gillespie, Delbert G et al. (2015) Critical Role for the Adenosine Pathway in Controlling Simian Immunodeficiency Virus-Related Immune Activation and Inflammation in Gut Mucosal Tissues. J Virol 89:9616-30
Moroco, Jamie A; Baumgartner, Matthew P; Rust, Heather L et al. (2015) A Discovery Strategy for Selective Inhibitors of c-Src in Complex with the Focal Adhesion Kinase SH3/SH2-binding Region. Chem Biol Drug Des 86:144-55
Cillo, Anthony R; Hilldorfer, Benedict B; Lalama, Christina M et al. (2015) Virologic and immunologic effects of adding maraviroc to suppressive antiretroviral therapy in individuals with suboptimal CD4+ T-cell recovery. AIDS 29:2121-9

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