This application is a renewal for a pre-doctoral training program in Immunity and Infectious Disease at The Rockefeller University, an institution with a rich history in these areas. The Immunity and Infectious Disease Training Program is a specialized unit of the Ph.D. program at Rockefeller, and is specifically designed for immunology and infectious disease training. The training program includes required coursework, rotations, and extensive research opportunities. The 17 faculty trainers are accomplished scientists, including 4 members of the US National Academy of Sciences, with a shared interest and experience in graduate education. The faculty has expertise in a very broad range of immunology and infectious disease, and the program encourages trainees to perform collaborative work in various areas with different faculty. We propose to support 4 pre-doctoral trainees during years 1-3 of graduate study. The applicant pool is outstanding, including a large number of students with accomplished undergraduate records, extensive research experience and a strong interest in immunology and infectious disease. Trainees would be mentored by the Program Director~ a Program Advisory Committee of selected faculty for general curriculum and research advice~ and a Faculty Advisory Committee, specifically designed for each trainee to provide detailed experimental guidance. Finally, the University provides extensive support for the graduate program in general, which benefits the Immunity and Infectious Disease training program. The confluence of these attributes defines a specific training program that would equip trainees with the educational background, analytical abilities, and experimental expertise to forge future advances in immunology and infectious disease.

Public Health Relevance

This training grant supports research and education that is directly relevant t public health, including clinically relevant coursework and research opportunities in areas such as the development of treatments for cancer and new vaccines for HIV and Hepatitis C.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Institutional National Research Service Award (T32)
Project #
2T32AI070084-06
Application #
8551252
Study Section
Allergy & Clinical Immunology-1 (AITC)
Program Officer
Robbins, Christiane M
Project Start
2006-07-01
Project End
2018-04-30
Budget Start
2013-05-22
Budget End
2014-04-30
Support Year
6
Fiscal Year
2013
Total Cost
$181,642
Indirect Cost
$8,714
Name
Rockefeller University
Department
Microbiology/Immun/Virology
Type
Other Domestic Higher Education
DUNS #
071037113
City
New York
State
NY
Country
United States
Zip Code
10065
Goldberg, Gregory W; Jiang, Wenyan; Bikard, David et al. (2014) Conditional tolerance of temperate phages via transcription-dependent CRISPR-Cas targeting. Nature 514:633-7
Klein, Florian; Nogueira, Lilian; Nishimura, Yoshiaki et al. (2014) Enhanced HIV-1 immunotherapy by commonly arising antibodies that target virus escape variants. J Exp Med 211:2361-72
Halper-Stromberg, Ariel; Lu, Ching-Lan; Klein, Florian et al. (2014) Broadly neutralizing antibodies and viral inducers decrease rebound from HIV-1 latent reservoirs in humanized mice. Cell 158:989-99
Bikard, David; Euler, Chad W; Jiang, Wenyan et al. (2014) Exploiting CRISPR-Cas nucleases to produce sequence-specific antimicrobials. Nat Biotechnol 32:1146-50
Malbec, Marine; Porrot, Francoise; Rua, Rejane et al. (2013) Broadly neutralizing antibodies that inhibit HIV-1 cell to cell transmission. J Exp Med 210:2813-21
Rumah, Kareem Rashid; Linden, Jennifer; Fischetti, Vincent A et al. (2013) Isolation of Clostridium perfringens type B in an individual at first clinical presentation of multiple sclerosis provides clues for environmental triggers of the disease. PLoS One 8:e76359
Zhou, Tongqing; Zhu, Jiang; Wu, Xueling et al. (2013) Multidonor analysis reveals structural elements, genetic determinants, and maturation pathway for HIV-1 neutralization by VRC01-class antibodies. Immunity 39:245-58