The goal of the Immunology Training Program (ITP) is to train PhD and MD/PhD scientists for outstanding careers in immunology-related research. The program includes a wide range of Immunology-related topics, spanning from basic research in areas such as innate immunity, T cell activation, tolerance, antigen processing and presentation, MHC function, complement, antibody structure and function, and mucosal immunity to research in clinically relevant models of infectious diseases (e.g. tuberculosis, HIV), vaccine development, immunopathology, transplantation and autoimmunity. Participating departments provide a rich confluence of basic science and clinical activities and resources, enriching the training of PhD students as they engage in basic and/or translational research in the field of immunology. To accomplish these training goals, the ITP has been developed as a track within the Pathology Graduate Program. Training for the PhD degree in the ITP includes course work, research rotations, formal and informal seminars, a Thesis Proposal Defense/Qualifying Examination, and research experience resulting in scholarly publications and a PhD dissertation. Trainers and research laboratories are located in multiple departments at Case School of Medicine and its affiliated institutions. University Hospitals Case Medical Center (UHCMC), the Cleveland Clinic Foundation (CCF, including the Lerner Research Institute) and the Louis Stokes VA Medical Center (VAMC). The extensive inter-departmental and inter-institutional participation is underscored by explicit co-sponsorship of the ITP by the CWRU Department of Pathology, CCF Department of Immunology, CWRU/UHCMC Division of Infectious Diseases, CWRU Center for Global Health and CWRU/UHCMC Visual Sciences Research Center. Other ITP trainers are located in a wide number of other departments at Case, CCF, UHCMC, MHMC and VAMC. Regardless of their primary affiliation, ITP Trainers hold faculty or trainer appointments in the Case Department of Pathology.

Public Health Relevance

The Immunology Training Program provides PhD training to produce future investigators who will drive important biomedical research efforts in Immunology and Immunology-related areas of clinical importance, such as infectious diseases, vaccine development, and organ transplantation autoimmunity.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Institutional National Research Service Award (T32)
Project #
5T32AI089474-05
Application #
8617791
Study Section
Allergy & Clinical Immunology-1 (AITC)
Program Officer
Prograis, Lawrence J
Project Start
2010-05-15
Project End
2015-04-30
Budget Start
2014-05-01
Budget End
2015-04-30
Support Year
5
Fiscal Year
2014
Total Cost
$179,056
Indirect Cost
$8,856
Name
Case Western Reserve University
Department
Pathology
Type
Schools of Medicine
DUNS #
077758407
City
Cleveland
State
OH
Country
United States
Zip Code
44106
Zidar, David A; Mudd, Joseph C; Juchnowski, Steven et al. (2016) Altered Maturation Status and Possible Immune Exhaustion of CD8 T Lymphocytes in the Peripheral Blood of Patients Presenting With Acute Coronary Syndromes. Arterioscler Thromb Vasc Biol 36:389-97
Freeman, Michael L; Mudd, Joseph C; Shive, Carey L et al. (2016) CD8 T-Cell Expansion and Inflammation Linked to CMV Coinfection in ART-treated HIV Infection. Clin Infect Dis 62:392-6
Shive, Carey L; Clagett, Brian; McCausland, Marie R et al. (2016) Inflammation Perturbs the IL-7 Axis, Promoting Senescence and Exhaustion that Broadly Characterize Immune Failure in Treated HIV Infection. J Acquir Immune Defic Syndr 71:483-92
Russo, Hana M; Rathkey, Joseph; Boyd-Tressler, Andrea et al. (2016) Active Caspase-1 Induces Plasma Membrane Pores That Precede Pyroptotic Lysis and Are Blocked by Lanthanides. J Immunol 197:1353-67
Clark, Heather L; Jhingran, Anupam; Sun, Yan et al. (2016) Zinc and Manganese Chelation by Neutrophil S100A8/A9 (Calprotectin) Limits Extracellular Aspergillus fumigatus Hyphal Growth and Corneal Infection. J Immunol 196:336-44
Iida, Shoichi; Tsuda, Hidetoshi; Tanaka, Toshiaki et al. (2016) IL-1 Receptor Signaling on Graft Parenchymal Cells Regulates Memory and De Novo Donor-Reactive CD8 T Cell Responses to Cardiac Allografts. J Immunol 196:2827-37
Jones, Mark B; Ryan, Sean O; Johnson, Jenny L et al. (2016) Dendritic cell-specific Mgat2 knockout mice show antigen presentation defects but reveal an unexpected CD11c expression pattern. Glycobiology 26:1007-1013
Mudd, Joseph C; Panigrahi, Soumya; Kyi, Benjamin et al. (2016) Inflammatory Function of CX3CR1+ CD8+ T Cells in Treated HIV Infection Is Modulated by Platelet Interactions. J Infect Dis 214:1808-1816
Panigrahi, Soumya; Freeman, Michael L; Funderburg, Nicholas T et al. (2016) SIV/SHIV Infection Triggers Vascular Inflammation, Diminished Expression of Kr├╝ppel-like Factor 2 and Endothelial Dysfunction. J Infect Dis 213:1419-27
Shukla, Sourabh; Dorand, R Dixon; Myers, Jay T et al. (2016) Multiple Administrations of Viral Nanoparticles Alter in Vivo Behavior-Insights from Intravital Microscopy. ACS Biomater Sci Eng 2:829-837

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