This competitive renewal proposes to continue its strong track record of training future leaders of academic dermatology. Of the 21 trainees supported for one or more years by this T32 program during the past ten years and who have completed their subspecialty and/or research training, 12 subsequently received full- time appointments to academic department, with major basic and/or clinical research commitments for 10 of them. Our emphasis on the development of the research skills of MD and MD/PhD dermatologists will be maintained;although PhD candidates judged likely to make substantive contributions to investigative dermatology will be considered for unfilled positions. Our department provides an environment conducive to training research dermatologists: thirteen of the 28 full-time primary Dermatology faculties are actively engaged in basic and/or clinical research, spending more than 50% effort on such research activities;eight are identified as potential preceptors in this renewal application. Our dermatology-based research faculty interacts extensively with investigators from other departments at Yale, including 16 internationally recognized researchers designated as potential preceptors for this training program. Because we consider it most conducive to the trainees'development of intellectual independence and to the introduction of new scientific skills into the dermatology community, substantial exposure to outstanding basic scientists outside of our department will continue to be mandatory. As during the past two funding periods, each trainee will have two advisors, one inside and one outside the Dermatology Department. In the usual circumstance in which the principal laboratory experience is outside the department, under the mentorship of one of the designated non-dermatologist basic scientists or another equivalent individual, the Dermatology faculty advisor will monitor progress of the trainee and certify that the training program is relevant to the trainee's future in the specialty. Training opportunities will continue to be available throughout a broad range of research arenas relevant to cutaneous biology.

National Institute of Health (NIH)
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Institutional National Research Service Award (T32)
Project #
Application #
Study Section
Arthritis and Musculoskeletal and Skin Diseases Special Grants Review Committee (AMS)
Program Officer
Cibotti, Ricardo
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Yale University
Schools of Medicine
New Haven
United States
Zip Code
Boyden, Lynn M; Craiglow, Brittany G; Zhou, Jing et al. (2015) Dominant De Novo Mutations in GJA1 Cause Erythrokeratodermia Variabilis et Progressiva, without Features of Oculodentodigital Dysplasia. J Invest Dermatol 135:1540-7
Levinsohn, Jonathan L; Teng, Joyce; Craiglow, Brittany G et al. (2014) Somatic HRAS p.G12S mutation causes woolly hair and epidermal nevi. J Invest Dermatol 134:1149-52
Bunick, Christopher G (2014) Perspectives on physiology and medicine from Nobel Prize Winners: the 64th Lindau Nobel Laureate Meeting. J Invest Dermatol 134:2853-5
Gonzalez, A L; Berger, C L; Remington, J et al. (2014) Integrin-driven monocyte to dendritic cell conversion in modified extracorporeal photochemotherapy. Clin Exp Immunol 175:449-57
Futterleib, Jeffrey S; Feng, Hao; Tigelaar, Robert E et al. (2014) Activation of GILZ gene by photoactivated 8-methoxypsoralen: potential role of immunoregulatory dendritic cells in extracorporeal photochemotherapy. Transfus Apher Sci 50:379-87
Choi, Jaehyuk; Landrette, Sean F; Wang, Tiffany et al. (2014) Identification of PLX4032-resistance mechanisms and implications for novel RAF inhibitors. Pigment Cell Melanoma Res 27:253-62
Bunick, Christopher G; King, Brett A; Ibrahim, Omer (2014) When erythema ab igne warrants an evaluation for internal malignancy. Int J Dermatol 53:e353-5
Craiglow, Brittany G (2013) Ichthyosis in the newborn. Semin Perinatol 37:26-31
Craiglow, Brittany G; Choate, Keith A; Milstone, Leonard M (2013) Topical tazarotene for the treatment of ectropion in ichthyosis. JAMA Dermatol 149:598-600
Das, Rituparna; Moss, Jeremy E; Robinson, Eve et al. (2011) Role of macrophage migration inhibitory factor in the Th2 immune response to epicutaneous sensitization. J Clin Immunol 31:666-80

Showing the most recent 10 out of 42 publications