The Stanford Postgraduate Training Program in cutaneous Biology is designed to provide synergistic interactions between cutting edge basic science and translational research in dermatology. The P.I., Dr. Hanawalt, Professor of Biology and Dermatology with over 22 years experience directing graduate programs and training grants in Molecular and Cell Biology and Dermatology, exemplifies this synergism. The Co P.I., Dr. Khavari, Associate Professor of Dermatology, brings a clear focus to applying basic insights to skin disease. Three major features underscore the training environment. First, the Dermatology Department is now embedded within basic science lab space; The Dermatology laboratories under the direction of Drs. Oro, Marinkovich, Herron, Karasek, and Khavari moved last year to the new Center for Clinical Sciences Research, further strengthening the core interest in Cutaneous biology. Second, the program benefits from multidisciplinary involvement, continuing the tradition of the participation of senior faculty. These include preceptors, former Chair of Biology (Hanawalt), the Chair of Molecular and Cellular Physiology (Nelson) and the Chairs of Developmental Biology (Nusse, Scott) as well as other leaders in basic research within Epithelial Biology (Barsh/HHMI Genetics, Axelrod/Pathology and Seung Kim/Developmental Biology). Third, this multidisciplinary focus is now embodied in the new Stanford Program in Epithelial Biology, an interactive community centered within Dermatology directed at themes common to all epithelia. These themes encompass the research training opportunities of tissue polarity, differentiation, cell cycle control, carcinogenesis, adhesion, DNA repair, stem cell biology and the delivery of molecular therapeutics to epithelial tissues. M.D. candidates who plan careers in investigative dermatology requiring extensive backgrounds in basic laboratory science, or Ph.D. candidates pursuing research in skin biology in an integrative environment including clinical aspects, are encouraged to apply. Recruitment of trainees is selective and based on academic record, letters of evaluation, a strong foundation in clinical dermatology and/or basic science, and publication record.

Agency
National Institute of Health (NIH)
Institute
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Type
Institutional National Research Service Award (T32)
Project #
5T32AR007422-25
Application #
7091571
Study Section
Arthritis and Musculoskeletal and Skin Diseases Special Grants Review Committee (AMS)
Program Officer
Baker, Carl
Project Start
1981-07-01
Project End
2007-04-30
Budget Start
2006-05-01
Budget End
2007-04-30
Support Year
25
Fiscal Year
2006
Total Cost
$148,796
Indirect Cost
Name
Stanford University
Department
Dermatology
Type
Schools of Medicine
DUNS #
009214214
City
Stanford
State
CA
Country
United States
Zip Code
94305
Whitson, Ramon J; Lee, Alex; Urman, Nicole M et al. (2018) Noncanonical hedgehog pathway activation through SRF-MKL1 promotes drug resistance in basal cell carcinomas. Nat Med 24:271-281
Spitale, Robert C; Flynn, Ryan A; Zhang, Qiangfeng Cliff et al. (2015) Structural imprints in vivo decode RNA regulatory mechanisms. Nature 519:486-90
Sebastiano, Vittorio; Zhen, Hanson Hui; Haddad, Bahareh et al. (2014) Human COL7A1-corrected induced pluripotent stem cells for the treatment of recessive dystrophic epidermolysis bullosa. Sci Transl Med 6:264ra163
Kretz, Markus; Siprashvili, Zurab; Chu, Ci et al. (2013) Control of somatic tissue differentiation by the long non-coding RNA TINCR. Nature 493:231-5
Tsai, Miao-Chih; Spitale, Robert C; Chang, Howard Y (2011) Long intergenic noncoding RNAs: new links in cancer progression. Cancer Res 71:3-7
Spitale, Robert C; Tsai, Miao-Chih; Chang, Howard Y (2011) RNA templating the epigenome: long noncoding RNAs as molecular scaffolds. Epigenetics 6:539-43
Cline, Susan D; Hanawalt, Philip C (2006) Topoisomerase deficiencies subtly enhance global genomic repair of ultraviolet-induced DNA damage in Saccharomyces cerevisiae. DNA Repair (Amst) 5:611-7
Siprashvili, Zurab; Reuter, Jason A; Khavari, Paul A (2004) Intracellular delivery of functional proteins via decoration with transporter peptides. Mol Ther 9:721-8
Chang, Howard Y; Sneddon, Julie B; Alizadeh, Ash A et al. (2004) Gene expression signature of fibroblast serum response predicts human cancer progression: similarities between tumors and wounds. PLoS Biol 2:E7
Romero, L I; Zhang, D N; Cooke, J P et al. (2000) Differential expression of nitric oxide by dermal microvascular endothelial cells from patients with scleroderma. Vasc Med 5:147-58

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