This continuation of an established program emphasizes the techniques and concepts of cellular and molecular biology, genetics, and fundamental studies of immunology and bone biology of rheumatic diseases. Original population-based clinical research employs rigorous methodological design and statistical analysis. Support is requested for 6 postdoctoral trainees having either an M.D., or Ph.D., or both, as well as for 1 predoctoral (Ph.D candidate) trainee. The faculty are carefully selected in areas of: 1) Basic Biology including, B Cell Biology, T Cell Biology and Antigen Presentation, Bone and Joint Biology and Molecular and Basic Cell Biology, 2) Translational Research in Animal Models in Rheumatic and Immunological Diseases and Human Immunology and Genetics of Rheumatic Disease and 3) Patient-Centered Research in the Epidemiology and Outcomes of Rheumatic Diseases. While the primary strength of the program resides in the direct and individual nature of the interaction in the laboratory between each fellow and the responsible faculty member(s), substantial didactic experiences and the medical school environment supplement training and a series of structures and activities foster interactions. Trainees audit semester courses at Harvard Medical School in their field of basic science, while population science investigators obtain an MPH at the Harvard School of Public Health. Graduate students begin training after completion of course work and are in the Harvard Ph.D Program in Biomedical and Biological Sciences. The program is based in the Division of Rheumatology, Immunology and Allergy at Brigham and Women's Hospital. Importantly, a significant number of faculty are part of the program but located at other Harvard Medical School affiliated Institutions and are selected based on their outstanding scientific and training expertise. They include faculty at 1) the Broad Institute, 2) Boston Children's Hospital, 3) Massachusetts General Hospital, 4) HMS Department of Microbiology and Immunology, and 5) the Harvard School of Dental Medicine. Its goal is to provide an ongoing pipeline of highly trained and expert investigators prepared for and focused in rheumatic disease research.

Public Health Relevance

The Division of Rheumatology, Immunology and Allergy at Brigham and Women's Hospital and this training grant vehicle provide the core that integrates basic and translational investigators across Harvard-affiliated institutions working in areas of basic biology and population science relevant to and focused in musculoskeletal and autoimmune rheumatic disease. Its goal is to provide an ongoing pipeline of select, highly trained and expert investigators prepared for and focused in rheumatic disease research.

Agency
National Institute of Health (NIH)
Institute
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Type
Institutional National Research Service Award (T32)
Project #
5T32AR007530-32
Application #
9058969
Study Section
Arthritis and Musculoskeletal and Skin Diseases Special Grants Review Committee (AMS)
Program Officer
Mao, Su-Yau
Project Start
1985-07-01
Project End
2020-04-30
Budget Start
2016-05-01
Budget End
2017-04-30
Support Year
32
Fiscal Year
2016
Total Cost
Indirect Cost
Name
Brigham and Women's Hospital
Department
Type
DUNS #
030811269
City
Boston
State
MA
Country
United States
Zip Code
Sparks, Jeffrey A; Barbhaiya, Medha; Tedeschi, Sara K et al. (2018) Inflammatory dietary pattern and risk of developing rheumatoid arthritis in women. Clin Rheumatol :
Tedeschi, Sara K; Bathon, Joan M; Giles, Jon T et al. (2018) Relationship Between Fish Consumption and Disease Activity in Rheumatoid Arthritis. Arthritis Care Res (Hoboken) 70:327-332
LaMarche, Nelson M; Kohlgruber, Ayano C; Brenner, Michael B (2018) Innate T Cells Govern Adipose Tissue Biology. J Immunol 201:1827-1834
Sparks, Jeffrey A; Chang, Shun-Chiao; Nguyen, Uyen-Sa D T et al. (2018) Smoking Behavior Changes in the Early Rheumatoid Arthritis Period and Risk of Mortality During Thirty-Six Years of Prospective Followup. Arthritis Care Res (Hoboken) 70:19-29
Sparks, Jeffrey A; Chang, Shun-Chiao; Nguyen, Uyen-Sa et al. (2018) Weight Change During the Early Rheumatoid Arthritis Period and Risk of Subsequent Mortality in Women With Rheumatoid Arthritis and Matched Comparators. Arthritis Rheumatol 70:18-29
Tedeschi, Sara K; Cui, Jing; Arkema, Elizabeth V et al. (2017) Elevated BMI and antibodies to citrullinated proteins interact to increase rheumatoid arthritis risk and shorten time to diagnosis: A nested case-control study of women in the Nurses' Health Studies. Semin Arthritis Rheum 46:692-698
Rao, Deepak A; Gurish, Michael F; Marshall, Jennifer L et al. (2017) Pathologically expanded peripheral T helper cell subset drives B cells in rheumatoid arthritis. Nature 542:110-114
Barbhaiya, Medha; Lu, Bing; Sparks, Jeffrey A et al. (2017) Influence of Alcohol Consumption on the Risk of Systemic Lupus Erythematosus Among Women in the Nurses' Health Study Cohorts. Arthritis Care Res (Hoboken) 69:384-392
Tedeschi, Sara K; Stone, Richard M; Helfgott, Simon M (2017) Calcium Pyrophosphate Crystal Inflammatory Arthritis (Pseudogout) with Myelodysplastic Syndrome: A New Paraneoplastic Syndrome? J Rheumatol 44:1101-1102
Tedeschi, Sara K; Guan, Hongshu; Fine, Alexander et al. (2016) Organ-specific systemic lupus erythematosus activity during pregnancy is associated with adverse pregnancy outcomes. Clin Rheumatol 35:1725-32

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