The overall objective of this research training program is to provide a broad investigational experience in laboratory or non-laboratory research related to rheumatic diseases. The Program focuses on autoimmunity and the connective tissue diseases. Formal curricula as well as an interdisciplinary emphasis on disease pathogenesis provide a structure for the training program. The program is designed to provide cross- fertilization between individuals with a basic science background and those with clinical training. Pre- doctoral candidates (three positions requested) and postdoctoral fellows (two positions requested) may select mentors from a diverse clinical and basic science faculty. The infrastructure for carrying out clinical research is enhanced by the University's GCRC and the recently funded CTSA. The program in systemic autoimmune disease (lupus, Sjogren's syndrome, rheumatoid arthritis) is the largest GCRC user. Training opportunities in clinical/translational research were strengthened through faculty recruitment over the past funding period. Research interests of the training faculty fall into the following categories: 1) Myeloid cell function, 2) lymphocyte biology, 3) animal models, 4) immunotherapy, cytokines, chemokines, 5) clinical immunology/biomarkers, 6) stem cell biology, 7) genetics/epigenetics of autoimmune disease, and 8) gene/cell therapy. The training program is largely preceptorial, with more than 75% of the trainee's time devoted to independent research activities and the rest spent in formal courses and conferences. The curriculum is tailored to trainees'individual needs. The Faculty has a strong track record of active collaboration. Participating departments are Medicine;Pediatrics;Pathology, Immunology &Laboratory Medicine;Molecular Genetics &Microbiology;Biochemistry &Molecular Biology;Epidemiology &Biostatistics;Health Policy &Epidemiology;Oral Biology;and Oral Surgery. Trainees completing the program over the past 5 and 10-year periods have been highly successful in terms of research publications and their subsequent career development, and 6 of 11 individuals who have completed their training have assumed positions in academia and 3 in industry.

National Institute of Health (NIH)
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Institutional National Research Service Award (T32)
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Arthritis and Musculoskeletal and Skin Diseases Special Grants Review Committee (AMS)
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Mancini, Marie
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University of Florida
Internal Medicine/Medicine
Schools of Medicine
United States
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Xu, Yuan; Zhuang, Haoyang; Han, Shuhong et al. (2015) Mechanisms of tumor necrosis factor ? antagonist-induced lupus in a murine model. Arthritis Rheumatol 67:225-37
Reeves, Westley H (2014) Editorial: systemic lupus erythematosus: death by fire and ICE? Arthritis Rheumatol 66:6-9
Zhuang, Haoyang; Han, Shuhong; Xu, Yuan et al. (2014) Toll-like receptor 7-stimulated tumor necrosis factor ? causes bone marrow damage in systemic lupus erythematosus. Arthritis Rheumatol 66:140-51
Pawar, Rahul D; Goilav, Beatrice; Xia, Yumin et al. (2014) Serum autoantibodies in pristane induced lupus are regulated by neutrophil gelatinase associated lipocalin. Clin Immunol 154:49-65
Wallet, M A; Calderon, N l; Alonso, T R et al. (2013) Triclosan alters antimicrobial and inflammatory responses of epithelial cells. Oral Dis 19:296-302
Nahid, Md A; Yao, Bing; Dominguez-Gutierrez, Paul R et al. (2013) Regulation of TLR2-mediated tolerance and cross-tolerance through IRAK4 modulation by miR-132 and miR-212. J Immunol 190:1250-63
Wang, Qiwei; Wang, Hai; Sun, Yu et al. (2013) The reprogrammed pancreatic progenitor-like intermediate state of hepatic cells is more susceptible to pancreatic beta cell differentiation. J Cell Sci 126:3638-48
Xu, Yuan; Lee, Pui Y; Li, Yi et al. (2012) Pleiotropic IFN-dependent and -independent effects of IRF5 on the pathogenesis of experimental lupus. J Immunol 188:4113-21
Nahid, Md A; Rivera, Mercedes; Lucas, Alexandra et al. (2011) Polymicrobial infection with periodontal pathogens specifically enhances microRNA miR-146a in ApoE-/- mice during experimental periodontal disease. Infect Immun 79:1597-605
Delano, Matthew J; Thayer, Terri; Gabrilovich, Sonia et al. (2011) Sepsis induces early alterations in innate immunity that impact mortality to secondary infection. J Immunol 186:195-202

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