This proposal is a competitive renewal of a National Research Service Award for Rheumatology Research Training at Northwestern University Feinberg School of Medicine. This request responds to the ongoing, compelling need for Rheumatology research training by providing organized leadership and infrastructure for rigorous mentored research and didactic experiences, all of which have proven to be successful in the current funding period. The program builds on the strengths of current training initiatives in clinical and translational, public health and health services research and on the considerable scientific and research training experiences of Rheumatology faculty and collaborators from a wide variety of medical school departments, centers, and institutes. This request for renewal of the T32 in Rheumatology research comes at a time of substantial and sustained growth in the research enterprise of Feinberg School of Medicine. The long-term, overriding, goal of this training program is to nurture bright, enthusiastic, well-trained, academically-oriented M.D.s and Ph.D.s in their pursuit of a career in Rheumatology investigation, by enabling them to synthesize information about the complex issues associated with conducting scientifically and ethically sound research, and to maximize the likelihood that they will be competitive in seeking subsequent, independent research support. The specific objectives of this training grant are: 1) to develop clinical and basic research scientists, who will ultimately be capable of independently performing hypothesis-driven research that addresses the needs of out target patient population;2) to provide stipend support and protected time for research trainees;3) to sustain and improve an administrative structure that enhances the training environment;4) to provide both basic and clinical science trainees a rigorous base of classroom study in the disciplines necessary for successfully conducting research relevant to disease etiology, pathogenesis, outcomes, and for the provision of innovative care to patients with arthritis, musculoskeletal, and autoimmune disorders;5) to continue an ongoing evaluation process, modifying the program when appropriate to fully meet its goals and objectives.

Public Health Relevance

There is a critical need to train highly competent M.D. and Ph.D. investigators to conduct patient-oriented research leading to improved care for patients with arthritis and related conditions. The shortage of clinical research trainees has reached crisis proportions in academic medicine and this urgent situation is especially pertinent for Rheumatology research trainees. The long-term, overriding, goal of the Northwestern University Rheumatology Research Training Program is to nurture motivated, bright, enthusiastic, well-trained, academically-oriented M.D.s and Ph.D.s in their pursuit of careers in Rheumatology investigation, training them to become the next generation of leaders in research.

National Institute of Health (NIH)
Institutional National Research Service Award (T32)
Project #
Application #
Study Section
Arthritis and Musculoskeletal and Skin Diseases Special Grants Review Committee (AMS)
Program Officer
Mao, Su-Yau
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Northwestern University at Chicago
Internal Medicine/Medicine
Schools of Medicine
United States
Zip Code
Lertratanakul, Apinya; Wu, Peggy; Dyer, Alan et al. (2014) 25-hydroxyvitamin D and cardiovascular disease in patients with systemic lupus erythematosus: data from a large international inception cohort. Arthritis Care Res (Hoboken) 66:1167-76
Khare, Sonal; Ratsimandresy, Rojo A; de Almeida, LĂșcia et al. (2014) The PYRIN domain-only protein POP3 inhibits ALR inflammasomes and regulates responses to infection with DNA viruses. Nat Immunol 15:343-53
Mattson, E C; Johns, J E; Pande, K et al. (2014) Vibrational Excitations and Low Energy Electronic Structure of Epoxide-decorated Graphene. J Phys Chem Lett 5:212-219
Korman, Benjamin D; Huang, Chiang-Ching; Skamra, Carly et al. (2014) Inflammatory expression profiles in monocyte-to-macrophage differentiation in patients with systemic lupus erythematosus and relationship with atherosclerosis. Arthritis Res Ther 16:R147
Skamra, Carly; Romero-Diaz, Juanita; Sandhu, Alexander et al. (2013) Telomere length in patients with systemic lupus erythematosus and its associations with carotid plaque. Rheumatology (Oxford) 52:1101-8
Rose, Shawn; Eren, Mesut; Murphy, Sheila et al. (2013) A novel mouse model that develops spontaneous arthritis and is predisposed towards atherosclerosis. Ann Rheum Dis 72:89-95
Johns, James E; Alaboson, Justice M P; Patwardhan, Sameer et al. (2013) Metal oxide nanoparticle growth on graphene via chemical activation with atomic oxygen. J Am Chem Soc 135:18121-5
Johns, James E; Hersam, Mark C (2013) Atomic covalent functionalization of graphene. Acc Chem Res 46:77-86
Rose, Shawn; Waters, Emily A; Haney, Chad R et al. (2013) High-resolution magnetic resonance imaging of ankle joints in murine arthritis discriminates inflammation and bone destruction in a quantifiable manner. Arthritis Rheum 65:2279-89
Mavers, Melissa; Cuda, Carla M; Misharin, Alexander V et al. (2012) Cyclin-dependent kinase inhibitor p21, via its C-terminal domain, is essential for resolution of murine inflammatory arthritis. Arthritis Rheum 64:141-52

Showing the most recent 10 out of 21 publications