This proposal is a competitive renewal of a National Research Service Award for Rheumatology Research Training at Northwestern University Feinberg School of Medicine. This request responds to the ongoing, compelling need for Rheumatology research training by providing organized leadership and infrastructure for rigorous mentored research and didactic experiences, all of which have proven to be successful in the current funding period. The program builds on the strengths of current training initiatives in clinical and translational, public health and health services research and on the considerable scientific and research training experiences of Rheumatology faculty and collaborators from a wide variety of medical school departments, centers, and institutes. This request for renewal of the T32 in Rheumatology research comes at a time of substantial and sustained growth in the research enterprise of Feinberg School of Medicine. The long-term, overriding, goal of this training program is to nurture bright, enthusiastic, well-trained, academically-oriented M.D.s and Ph.D.s in their pursuit of a career in Rheumatology investigation, by enabling them to synthesize information about the complex issues associated with conducting scientifically and ethically sound research, and to maximize the likelihood that they will be competitive in seeking subsequent, independent research support. The specific objectives of this training grant are: 1) to develop clinical and basic research scientists, who will ultimately be capable of independently performing hypothesis-driven research that addresses the needs of out target patient population;2) to provide stipend support and protected time for research trainees;3) to sustain and improve an administrative structure that enhances the training environment;4) to provide both basic and clinical science trainees a rigorous base of classroom study in the disciplines necessary for successfully conducting research relevant to disease etiology, pathogenesis, outcomes, and for the provision of innovative care to patients with arthritis, musculoskeletal, and autoimmune disorders;5) to continue an ongoing evaluation process, modifying the program when appropriate to fully meet its goals and objectives.

Public Health Relevance

There is a critical need to train highly competent M.D. and Ph.D. investigators to conduct patient-oriented research leading to improved care for patients with arthritis and related conditions. The shortage of clinical research trainees has reached crisis proportions in academic medicine and this urgent situation is especially pertinent for Rheumatology research trainees. The long-term, overriding, goal of the Northwestern University Rheumatology Research Training Program is to nurture motivated, bright, enthusiastic, well-trained, academically-oriented M.D.s and Ph.D.s in their pursuit of careers in Rheumatology investigation, training them to become the next generation of leaders in research.

Agency
National Institute of Health (NIH)
Institute
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Type
Institutional National Research Service Award (T32)
Project #
5T32AR007611-13
Application #
8687484
Study Section
Arthritis and Musculoskeletal and Skin Diseases Special Grants Review Committee (AMS)
Program Officer
Mao, Su-Yau
Project Start
2001-06-05
Project End
2017-06-30
Budget Start
2014-07-01
Budget End
2015-06-30
Support Year
13
Fiscal Year
2014
Total Cost
Indirect Cost
Name
Northwestern University at Chicago
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
City
Chicago
State
IL
Country
United States
Zip Code
60611
Huang, Qi-Quan; Birkett, Robert; Doyle, Renee E et al. (2017) Association of Increased F4/80high Macrophages With Suppression of Serum-Transfer Arthritis in Mice With Reduced FLIP in Myeloid Cells. Arthritis Rheumatol 69:1762-1771
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Pellegrini, Christine A; Song, Jing; Semanik, Pamela A et al. (2017) Patients Less Likely to Lose Weight Following a Knee Replacement: Results From the Osteoarthritis Initiative. J Clin Rheumatol 23:355-360
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Reinke, Lauren; Lam, Anna P; Flozak, Annette S et al. (2016) Adiponectin inhibits Wnt co-receptor, Lrp6, phosphorylation and ?-catenin signaling. Biochem Biophys Res Commun 470:606-612
Mahieu, Mary; Yount, Susan; Ramsey-Goldman, Rosalind (2016) Patient-Reported Outcomes in Systemic Lupus Erythematosus. Rheum Dis Clin North Am 42:253-263

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