A group of investigators seeks to renew and expand the NIH-funded interdisciplinary training program in Muscle Research at the University of Minnesota, for both predoctoral and postdoctoral scientists. The primary purpose of this expansion is to add increased emphasis on basic and translational research on muscle disease. This program began four years ago with a primary focus on basic research. During this time, the Academic Health Center has placed a high priority on the expansion of muscle research at all levels, particularly translational research, defined here as research aimed at the development of new therapeutic approaches. The institution has recruited internationally prominent researchers in muscle disease and therapy and has established new institutes and facilities that support this research. Most importantly, in 2003, the Paul and Sheila Wellstone Muscular Dystrophy Center was established, under the direction of two members of our Program Faculty. The Medical School has committed substantial resources to this new Center, including new faculty positions and space in the Translational Research Facility, which is now under construction. These developments have led us to increase our Program Faculty from 14 to 23, and the number of annual trainee applications has increased from 16 to 34. To accommodate this increased level of activity, we propose that this training program be expanded to support 6 predoctoral trainees (from 4) and 2 postdoctoral trainees (from 1). Program faculty will be drawn from a wide range of departments in the Academic Health Center, and most of the graduate students will be enrolled as minors or majors in the interdepartmental graduate programs in (a) Biochemistry, Molecular Biology, and Biophysics or (b) Neuroscience. The intellectual center of the program is an intensive one-semester course entitled """"""""Muscle"""""""" taught by the program faculty and emphasizing both basic science and muscle disease. This course will be expanded to accommodate our increasing emphasis on muscle disease and translational research. This is augmented by a monthly seminar program, an annual symposium, and a summer laboratory course. The primary goal of the program is to help these exceptional young scientists develop the intellectual and technical tools needed for productive careers as independent investigators and educators in muscle research.

Agency
National Institute of Health (NIH)
Institute
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Type
Institutional National Research Service Award (T32)
Project #
5T32AR007612-09
Application #
7840487
Study Section
Arthritis and Musculoskeletal and Skin Diseases Special Grants Review Committee (AMS)
Program Officer
Boyce, Amanda T
Project Start
2001-05-01
Project End
2012-04-30
Budget Start
2010-05-01
Budget End
2011-04-30
Support Year
9
Fiscal Year
2010
Total Cost
$438,101
Indirect Cost
Name
University of Minnesota Twin Cities
Department
Biochemistry
Type
Schools of Medicine
DUNS #
555917996
City
Minneapolis
State
MN
Country
United States
Zip Code
55455
Martin, Peter D; James, Zachary M; Thomas, David D (2018) Effect of Phosphorylation on Interactions between Transmembrane Domains of SERCA and Phospholamban. Biophys J 114:2573-2583
Fealey, Michael E; Horn, Benjamin; Coffman, Christian et al. (2018) Dynamics of Dystrophin's Actin-Binding Domain. Biophys J 115:445-454
Hennen, Jared; Saunders, Cosmo A; Mueller, Joachim D et al. (2018) Fluorescence fluctuation spectroscopy reveals differential SUN protein oligomerization in living cells. Mol Biol Cell 29:1003-1011
Fealey, Michael E; Binder, Benjamin P; Uversky, Vladimir N et al. (2018) Structural Impact of Phosphorylation and Dielectric Constant Variation on Synaptotagmin's IDR. Biophys J 114:550-561
Cabelka, Christine A; Baumann, Cory W; Collins, Brittany C et al. (2018) Effects of ovarian hormones and estrogen receptor ? on physical activity and skeletal muscle fatigue in female mice. Exp Gerontol :
Stroik, Daniel R; Yuen, Samantha L; Janicek, Kevyn A et al. (2018) Targeting protein-protein interactions for therapeutic discovery via FRET-based high-throughput screening in living cells. Sci Rep 8:12560
Her, Cheng; Thompson, Andrew R; Karim, Christine B et al. (2018) Structural dynamics of calmodulin-ryanodine receptor interactions: electron paramagnetic resonance using stereospecific spin labels. Sci Rep 8:10681
Hennen, Jared; Angert, Isaac; Hur, Kwang-Ho et al. (2018) Investigating LINC Complex Protein Homo-oligomerization in the Nuclear Envelopes of Living Cells Using Fluorescence Fluctuation Spectroscopy. Methods Mol Biol 1840:121-135
Cain, Natalie E; Jahed, Zeinab; Schoenhofen, Amy et al. (2018) Conserved SUN-KASH Interfaces Mediate LINC Complex-Dependent Nuclear Movement and Positioning. Curr Biol 28:3086-3097.e4
Saunders, Cosmo A; Harris, Nathan J; Willey, Patrick T et al. (2017) TorsinA controls TAN line assembly and the retrograde flow of dorsal perinuclear actin cables during rearward nuclear movement. J Cell Biol 216:657-674

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