! The goals of this Musculoskeletal Research Training Program are to provide trans-disciplinary research opportunities for postdoctoral fellows, graduate students, and medical students at Mayo Clinic and to train them to be future leaders of biomedical research. Musculoskeletal ailments such as osteoarthritis, osteoporosis, back pain, tendonopathies, sarcopenia and fractures are some of the most common reasons why people of all ages visit a doctor. They significantly impact quality of life, cause disabilities, and pose large personal, societal and economic burdens. The repair, regeneration, or rejuvenation of musculoskeletal tissues and joints requires knowledge of complex and interconnected biomechanical, biological, and physiological processes. This program aims to train future biologists, engineers, and physicians/surgeons to solve orthopedic and musculoskeletal problems by providing outstanding research and educational opportunities within the setting of a state-of-the-art medical and research center. Twenty-eight faculty members, who are leaders in basic, translational, and clinical research of orthopedics and the musculoskeletal system, will mentor trainees by directing research projects and group discussions on timely topics. A peer-mentoring system provides new trainees with opportunities to receive advice and counseling from past trainees who successfully obtained independent fellowships. Postdoctoral fellows (5 per year) and graduate students (2 per year) will engage in multiyear projects and receive training in grant writing and career development. They will be expected to submit applications for independent fellowships and to participate in a full array of programmatic activities, including but not limited to journal clubs, seminars, symposia, webinars, national scientific meetings, and training in the responsible conduct of research. Medical students (2 per year) from fully accredited medical schools in the United States and her territories (i.e., Puerto Rico) will spend two to three months in the training program and are expected to complete a defined research project under the guidance of a mentor(s) and to participate in programmatic educational activities. This blended musculoskeletal research training program values individuals from diverse educational and societal backgrounds and benefits from the unique perspectives they bring to solving complex medical problems and reducing the burden of musculoskeletal diseases on patients, their families and our society.

Public Health Relevance

Musculoskeletal diseases are some of the most common reasons why people of all ages visit a doctor and are leading causes of disability. The prevalence of musculoskeletal conditions will continue to escalate in the next 10 to 20 years as the population ages. This trans-disciplinary program provides focused training at Mayo Clinic to a new generation of biomedical researchers who will advance the science and treatment of musculoskeletal diseases.

Agency
National Institute of Health (NIH)
Institute
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Type
Institutional National Research Service Award (T32)
Project #
2T32AR056950-11
Application #
9700793
Study Section
Special Emphasis Panel (ZAR1)
Program Officer
Chen, Faye H
Project Start
2009-05-01
Project End
2024-04-30
Budget Start
2019-05-01
Budget End
2020-04-30
Support Year
11
Fiscal Year
2019
Total Cost
Indirect Cost
Name
Mayo Clinic, Rochester
Department
Type
DUNS #
006471700
City
Rochester
State
MN
Country
United States
Zip Code
55905
Go, Shanette A; Litchy, William J; Evertz, Loribeth Q et al. (2018) Evaluating skeletal muscle electromechanical delay with intramuscular pressure. J Biomech 76:181-188
Hwang, Soyun M; Feigenson, Marina; Begun, Dana L et al. (2018) Phlpp inhibitors block pain and cartilage degradation associated with osteoarthritis. J Orthop Res 36:1487-1497
Ate?, Filiz; Davies, Brenda L; Chopra, Swati et al. (2018) Intramuscular Pressure of Tibialis Anterior Reflects Ankle Torque but Does Not Follow Joint Angle-Torque Relationship. Front Physiol 9:22
Mozingo, Joseph D; Akbari Shandiz, Mohsen; Marquez, Felicia M et al. (2018) Validation of imaging-based quantification of glenohumeral joint kinematics using an unmodified clinical biplane fluoroscopy system. J Biomech 71:306-312
Gustafson, Carl T; Mamo, Tewodros; Maran, Avudaiappan et al. (2018) Efflux inhibition by IWR-1-endo confers sensitivity to doxorubicin effects in osteosarcoma cells. Biochem Pharmacol 150:141-149
McGee-Lawrence, Meghan E; Pierce, Jessica L; Yu, Kanglun et al. (2018) Loss of Hdac3 in osteoprogenitors increases bone expression of osteoprotegerin, improving systemic insulin sensitivity. J Cell Physiol 233:2671-2680
Dudakovic, Amel; Camilleri, Emily T; Paradise, Christopher R et al. (2018) Enhancer of zeste homolog 2 (Ezh2) controls bone formation and cell cycle progression during osteogenesis in mice. J Biol Chem 293:12894-12907
McPherson, April L; Bates, Nathanial A; Schilaty, Nathan D et al. (2018) Ligament Strain Response Between Lower Extremity Contralateral Pairs During In Vitro Landing Simulation. Orthop J Sports Med 6:2325967118765978
Castillejo Becerra, Clara M; Mattson, Anna M; Molstad, David H H et al. (2018) DNA methylation and FoxO3a regulate PHLPP1 expression in chondrocytes. J Cell Biochem 119:7470-7478
Bates, Nathaniel A; Schilaty, Nathan D; Nagelli, Christopher V et al. (2017) Novel mechanical impact simulator designed to generate clinically relevant anterior cruciate ligament ruptures. Clin Biomech (Bristol, Avon) 44:36-44

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