The mission of this Program is to prepare a cadre of outstanding cancer epidemiologists through rigorous academic training in research methodology and the epidemiology and biology of cancer, and mentored research. Additional emphasis is placed on molecular and genetic epidemiology methods and applications. A distinguished faculty provides a variety of substantial opportunities for research experience. There are three types of trainees: Doctoral Candidates in Epidemiology includes pre-doctoral candidates either with or without a prior doctoral degree (generally clinicians) who undertake 2-3 years of coursework, in addition to research, in the course of earning a doctoral degree in Epidemiology;Clinical Researchers include physicians with specialty training in cancer preparing for careers in clinical epidemiology who undertake a one year Master's degree program in methodology followed by a year of research;and Post- doctoral Fellows who hold a prior doctoral degree in Epidemiology or in Biology and undertake mentored research (and with coursework if needed) in preparation for an academic career. Those trainee positions are generally awarded for 2 or 3 years. The number of trainee positions requested includes five pre-doctoral students and seven post-doctoral fellows, for a total of 12 trainees. The program had supported 16 trainees since 1998, but at the behest of the NIH project officer, we have reduced the requested number to 12. The Program is based in the Department of Epidemiology of the Harvard School of Public Health, and is also affiliated with the Channing Division of Network Medicine in the Department of Medicine, Brigham and Women's Hospital. A dedicated molecular epidemiology laboratory is available. This proposal continues a long history of excellence in training in cancer epidemiology at Harvard University;the current training program is now in its 37th year, with an outstanding record of achievement in training.
Knowledge about cancer epidemiology - the study of the determinants and distribution of cancer in human populations - has grown exponentially. With major advances in methodology, cancer biology and genetics, the need for well-trained highly skills researchers and clinicians in this area has never been greater. We propose, through this training grant, to continue to provide high quality cancer epidemiology training to educate the next generation of outstanding scholars and public health researchers in this vital field.
|Iyer, Hari S; Hirschhorn, Lisa R; Nisingizwe, Marie Paul et al. (2017) Impact of a district-wide health center strengthening intervention on healthcare utilization in rural Rwanda: Use of interrupted time series analysis. PLoS One 12:e0182418|
|Roberts, Michelle R; Sucheston-Campbell, Lara E; Zirpoli, Gary R et al. (2017) Single nucleotide variants in metastasis-related genes are associated with breast cancer risk, by lymph node involvement and estrogen receptor status, in women with European and African ancestry. Mol Carcinog 56:1000-1009|
|VoPham, Trang; Bertrand, Kimberly A; Hart, Jaime E et al. (2017) Pesticide exposure and liver cancer: a review. Cancer Causes Control 28:177-190|
|Seyerle, A A; Sitlani, C M; Noordam, R et al. (2017) Pharmacogenomics study of thiazide diuretics and QT interval in multi-ethnic populations: the cohorts for heart and aging research in genomic epidemiology. Pharmacogenomics J :|
|Ren, Natalie S X; Ji, Ming; Tokar, Erik J et al. (2017) Haploinsufficiency of SIRT1 Enhances Glutamine Metabolism and Promotes Cancer Development. Curr Biol 27:483-494|
|Walker, Erica D; Hart, Jaime E; Koutrakis, Petros et al. (2017) Spatial and temporal determinants of A-weighted and frequency specific sound levels-An elastic net approach. Environ Res 159:491-499|
|Beca, Francisco; Kensler, Kevin; Glass, Benjamin et al. (2017) EZH2 protein expression in normal breast epithelium and risk of breast cancer: results from the Nurses' Health Studies. Breast Cancer Res 19:21|
|VoPham, Trang; Bertrand, Kimberly A; Yuan, Jian-Min et al. (2017) Ambient ultraviolet radiation exposure and hepatocellular carcinoma incidence in the United States. Environ Health 16:89|
|Graff, Rebecca E; Judson, Gregory; Ahearn, Thomas U et al. (2017) Circulating Antioxidant Levels and Risk of Prostate Cancer by TMPRSS2:ERG. Prostate 77:647-653|
|Pernar, Claire H; Fall, Katja; Rider, Jennifer R et al. (2017) A Walking Intervention Among Men With Prostate Cancer: A Pilot Study. Clin Genitourin Cancer 15:e1021-e1028|
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