Funding is requested to prepare individuals for research careers in cancer-related immunology and lymphocyte transformation in an ongoing training program established about 30 years ago. Pre-doctoral trainees with strong motivation to enter cancer-related research careers who have completed their course work will be supported while they perform their thesis research to fulfill PhD degree requirements at the University of Pennsylvania. Post-doctoral trainees will undertake laboratory research training in the laboratory of a primary trainer with a research program in cancer-related research. This training program includes basic lecture courses in immunology and related disciplines, advanced seminar courses in various aspects of cancer immunology, cancer biology and bioethics, seminars from visiting scientists and PENN faculty, research conferences, workshops and retreats. Programs developed specifically for our trainees include a training grant retreat, a tumor immunology course, a lymphocyte development course, a journal club, and a visiting scholar/seminar program. Trainees, 5 predoctoral fellows and 8 postdoctoral fellows (M.D., Ph.D., or D.V.M.), are located in the research laboratories of the participating faculty. The major sites for cancer-related training in the University of Pennsylvania community are the Wistar Institute, the Departments of Medicine, Microbiology, Hematology/Oncology, Cancer Biology, Pathology &Lab Medicine, and the School of Veterinary Medicine. The training program is an integral component of the Cancer Center in the University of Pennsylvania School of Medicine. Candidates considered as trainees, regardless of the level at which they enter, are expected to meet high standards of competence, motivation and perseverance, and have a commitment to a research career in cancer-related immunology. Predoctoral trainees are selected from the BGS pool, after they have determined their thesis laboratory, to ensure their interest in cancer-related immunology. Post-doctoral trainees are selected competitively based on a national search. Recruitment of qualified, under-represented minorities takes precedence in this endeavor.

Public Health Relevance

This program provides training to develop future leaders in cancer research. As a catalyst for developing the next generation of principal investigators, this training program will impact directly on improving cancer treatment, decreasing costs, and most importantly, improving the lives of cancer patients, all of which are directly relevant to public health.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Institutional National Research Service Award (T32)
Project #
2T32CA009140-36
Application #
7768196
Study Section
Subcommittee G - Education (NCI)
Program Officer
Lim, Susan E
Project Start
1975-07-01
Project End
2015-04-30
Budget Start
2010-05-01
Budget End
2011-04-30
Support Year
36
Fiscal Year
2010
Total Cost
$676,639
Indirect Cost
Name
University of Pennsylvania
Department
Pathology
Type
Schools of Medicine
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104
Huang, Alexander C; Postow, Michael A; Orlowski, Robert J et al. (2017) T-cell invigoration to tumour burden ratio associated with anti-PD-1 response. Nature 545:60-65
Katlinski, Kanstantsin V; Gui, Jun; Katlinskaya, Yuliya V et al. (2017) Inactivation of Interferon Receptor Promotes the Establishment of Immune Privileged Tumor Microenvironment. Cancer Cell 31:194-207
Wilmore, Joel R; Jones, Derek D; Allman, David (2017) Protocol for improved resolution of plasma cell subpopulations by flow cytometry. Eur J Immunol 47:1386-1388
Conejo-Garcia, Jose R; Payne, Kyle K; Svoronos, Nikolaos (2017) Estrogens drive myeloid-derived suppressor cell accumulation. Oncoscience 4:5-6
Svoronos, Nikolaos; Perales-Puchalt, Alfredo; Allegrezza, Michael J et al. (2017) Tumor Cell-Independent Estrogen Signaling Drives Disease Progression through Mobilization of Myeloid-Derived Suppressor Cells. Cancer Discov 7:72-85
Kori, Yekaterina; Sidoli, Simone; Yuan, Zuo-Fei et al. (2017) Proteome-wide acetylation dynamics in human cells. Sci Rep 7:10296
Stephen, Tom L; Payne, Kyle K; Chaurio, Ricardo A et al. (2017) SATB1 Expression Governs Epigenetic Repression of PD-1 in Tumor-Reactive T Cells. Immunity 46:51-64
Layman, Awo Akosua; Sprout, Stephanie; Phillips, Dylan et al. (2017) Ndfip1 restricts Th17 cell potency by limiting lineage stability and proinflammatory cytokine production. Sci Rep 7:39649
Layman, Awo Akosua Kesewa; Deng, Guoping; O'Leary, Claire E et al. (2017) Ndfip1 restricts mTORC1 signalling and glycolysis in regulatory T cells to prevent autoinflammatory disease. Nat Commun 8:15677
Fayngerts, Svetlana A; Wang, Zhaojun; Zamani, Ali et al. (2017) Direction of leukocyte polarization and migration by the phosphoinositide-transfer protein TIPE2. Nat Immunol 18:1353-1360

Showing the most recent 10 out of 274 publications