Funding is requested to prepare individuals for research careers in cancer-related immunology and lymphocyte transformation in an ongoing training program established about 30 years ago. Pre-doctoral trainees with strong motivation to enter cancer-related research careers who have completed their course work will be supported while they perform their thesis research to fulfill PhD degree requirements at the University of Pennsylvania. Post-doctoral trainees will undertake laboratory research training in the laboratory of a primary trainer with a research program in cancer-related research. This training program includes basic lecture courses in immunology and related disciplines, advanced seminar courses in various aspects of cancer immunology, cancer biology and bioethics, seminars from visiting scientists and PENN faculty, research conferences, workshops and retreats. Programs developed specifically for our trainees include a training grant retreat, a tumor immunology course, a lymphocyte development course, a journal club, and a visiting scholar/seminar program. Trainees, 5 predoctoral fellows and 8 postdoctoral fellows (M.D., Ph.D., or D.V.M.), are located in the research laboratories of the participating faculty. The major sites for cancer-related training in the University of Pennsylvania community are the Wistar Institute, the Departments of Medicine, Microbiology, Hematology/Oncology, Cancer Biology, Pathology &Lab Medicine, and the School of Veterinary Medicine. The training program is an integral component of the Cancer Center in the University of Pennsylvania School of Medicine. Candidates considered as trainees, regardless of the level at which they enter, are expected to meet high standards of competence, motivation and perseverance, and have a commitment to a research career in cancer-related immunology. Predoctoral trainees are selected from the BGS pool, after they have determined their thesis laboratory, to ensure their interest in cancer-related immunology. Post-doctoral trainees are selected competitively based on a national search. Recruitment of qualified, under-represented minorities takes precedence in this endeavor.

Public Health Relevance

This program provides training to develop future leaders in cancer research. As a catalyst for developing the next generation of principal investigators, this training program will impact directly on improving cancer treatment, decreasing costs, and most importantly, improving the lives of cancer patients, all of which are directly relevant to public health.

National Institute of Health (NIH)
National Cancer Institute (NCI)
Institutional National Research Service Award (T32)
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Subcommittee G - Education (NCI)
Program Officer
Lim, Susan E
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University of Pennsylvania
Schools of Medicine
United States
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Santoro, Stephen P; Kim, Soorin; Motz, Gregory T et al. (2015) T cells bearing a chimeric antigen receptor against prostate-specific membrane antigen mediate vascular disruption and result in tumor regression. Cancer Immunol Res 3:68-84
Psathas, James N; Thomas-Tikhonenko, Andrei (2014) MYC and the art of microRNA maintenance. Cold Spring Harb Perspect Med 4:
Schadler, Keri L; Crosby, Erika J; Zhou, Alice Yao et al. (2014) Immunosurveillance by antiangiogenesis: tumor growth arrest by T cell-derived thrombospondin-1. Cancer Res 74:2171-81
Gerhardt, Dawson M; Pajcini, Kostandin V; D'altri, Teresa et al. (2014) The Notch1 transcriptional activation domain is required for development and reveals a novel role for Notch1 signaling in fetal hematopoietic stem cells. Genes Dev 28:576-93
Rupp, Levi J; Brady, Brenna L; Carpenter, Andrea C et al. (2014) The microRNA biogenesis machinery modulates lineage commitment during ?? T cell development. J Immunol 193:4032-42
Smith, Jenessa B; Stashwick, Caitlin; Powell Jr, Daniel J (2014) B7-H4 as a potential target for immunotherapy for gynecologic cancers: a closer look. Gynecol Oncol 134:181-9
Lanitis, Evripidis; Smith, Jenessa B; Dangaj, Denarda et al. (2014) A human ErbB2-specific T-cell receptor confers potent antitumor effector functions in genetically engineered primary cytotoxic lymphocytes. Hum Gene Ther 25:730-9
Motz, Gregory T; Santoro, Stephen P; Wang, Li-Ping et al. (2014) Tumor endothelium FasL establishes a selective immune barrier promoting tolerance in tumors. Nat Med 20:607-15
Motz, Greg T; Coukos, George (2013) Deciphering and reversing tumor immune suppression. Immunity 39:61-73
Zaslavsky, Alexander; Chou, Stella T; Schadler, Keri et al. (2013) The calcineurin-NFAT pathway negatively regulates megakaryopoiesis. Blood 121:3205-15

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