We are requesting continuation funds for a research training program in the Pediatric Oncology Program at the Fred Hutchinson Cancer Research Center and the Department of Pediatrics, University of Washington. The purpose of the proposed program is to train promising physicians to become independent investigative pediatric oncologists. In the first year of the program, which is funded by sources other than this grant, trainees receive intensive exposure to clinical care and clinical research. In their second and third years, the trainees commit themselves commit themselves to a major research effort. Research projects in the areas of hematopoietic stem cell transplantation, immunology and immunotherapy of leukemia and lymphoma, transplantation biology, normal and malignant hematopoiesis, human immunogenetics, neurooncology, cancer survivorship, molecular biology and gene therapy, and epidemiology, as well as other programs, are available.
The aim of the projects will be to contribute new and useful information relevant to pediatric oncology and to develop the research capabilities of the trainees to allow them to establish themselves as independent investigators. Physicians who have completed three years of training as residents in pediatrics will be eligible. Those most qualified and motivated to enter into investigative endeavors will be selected. In the past, many of the applicants have had previous laboratory experience. Of the twenty-one trainees supported by this NRSA who have completed their training during the past ten years, eighteen have remained in academic pediatric oncology. We are requesting funding for two postdoctoral fellowships per year in a two-year program (a total of four positions). This program involves the laboratory and clinical research facilities of the Fred Hutchinson Cancer Research Center and the University of Washington;the clinical facilities of the Division of Hematology- Oncology at the Children's Hospital and Regional Medical Center, the primary clinical pediatric service of the University of Washington;and the clinical facilities of the pediatric oncology service of the Fred Hutchinson Cancer Research Center.

National Institute of Health (NIH)
National Cancer Institute (NCI)
Institutional National Research Service Award (T32)
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Study Section
Subcommittee G - Education (NCI)
Program Officer
Lim, Susan E
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Fred Hutchinson Cancer Research Center
United States
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Cheung, Ronald S; Castella, Maria; Abeyta, Antonio et al. (2017) Ubiquitination-Linked Phosphorylation of the FANCI S/TQ Cluster Contributes to Activation of the Fanconi Anemia I/D2 Complex. Cell Rep 19:2432-2440
Kutny, M A; Alonzo, T A; Gamazon, E R et al. (2015) Ethnic variation of TET2 SNP rs2454206 and association with clinical outcome in childhood AML: a report from the Children's Oncology Group. Leukemia 29:2424-6
Dahlberg, A; Woo, S; Delaney, C et al. (2015) Notch-mediated expansion of cord blood progenitors: maintenance of transcriptional and epigenetic fidelity. Leukemia 29:1948-51
Carter, John H; Lenahan, Jennifer L; Ishak, Gisele E et al. (2015) Medical management of invasive fungal infections of the central nervous system in pediatric cancer patients. Pediatr Blood Cancer 62:1095-8
Hadland, Brandon K; Varnum-Finney, Barbara; Poulos, Michael G et al. (2015) Endothelium and NOTCH specify and amplify aorta-gonad-mesonephros-derived hematopoietic stem cells. J Clin Invest 125:2032-45
Tarlock, Katherine; Alonzo, Todd A; Moraleda, Pilar Palomo et al. (2014) Acute myeloid leukaemia (AML) with t(6;9)(p23;q34) is associated with poor outcome in childhood AML regardless of FLT3-ITD status: a report from the Children's Oncology Group. Br J Haematol 166:254-259
Rosenberg, Abby R; Starks, Helene; Jones, Barbara (2014) ""I know it when I see it."" The complexities of measuring resilience among parents of children with cancer. Support Care Cancer 22:2661-8
Molina, Yamile; Yi, Jean C; Martinez-Gutierrez, Javiera et al. (2014) Resilience among patients across the cancer continuum: diverse perspectives. Clin J Oncol Nurs 18:93-101
Rosenberg, Abby R; Wolfe, Joanne; Bradford, Miranda C et al. (2014) Resilience and psychosocial outcomes in parents of children with cancer. Pediatr Blood Cancer 61:552-7
Dahlberg, A; Brashem-Stein, C; Delaney, C et al. (2014) Enhanced generation of cord blood hematopoietic stem and progenitor cells by culture with StemRegenin1 and Delta1(Ext-IgG.). Leukemia 28:2097-101

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