The objective of this competitive renewal training grant application is to promote and support the successful career of pediatric hematologist-oncologists as physician-scientists in cancer research. There has been dramatic progress in biomedical research over the last 2 decades and it is now critical that this knowledge translate into new and better diagnostic and therapeutic advances for patients. Physician-scientists with strong research training play a critical role in this regard because of their dual training in research and clinical care. Paradoxically, the pool of such individuals has in fact decreased since the late 1990's. There is however indication that, as a result of initiatives taken by the NIH and other foundations, there is a progressive increase in "late bloomers" interested in a research career. This T32 grant application funded since 1991 by the NIH will now specifically target a group of such individuals with training in Pediatric Oncology. Twenty-eight faculty members at Childrens Hospital Los Angeles, the Keck School of Medicine of the University of Southern California and City of Hope, with more than $ 26 million in extramural funding and with a combined expertise in laboratory, clinical and population-based research, will contribute as mentors and faculty resourced. The proposed training program will provide a minimum of 2 years of training in cancer research to 2 new individuals each year, who will be selected from the Pediatric Hematology-Oncology Fellowship Program pt Childrens Hospital Los Angeles, a program with a solid record of training academic physicians. This training program will be conducted within the strong research and education environments of The Saban Research Institute of Childrens Hospital Los Angeles, the Norris Comprehensive Cancer Center of the Keck School of Medicine and City of Hope, which will provide the trainees with a comprehensive curriculum that combines formal classes, workshops and seminars, one-on-one education sessions, and access to more than 20 core facilities. It is anticipated that individuals who complete this training program will contribute to enhancing the pool of physician-scientists in the nation and most particularly in the field of pediatric cancer.

Public Health Relevance

This training grant application focuses on addressing the critical issue of the shortage of physician-scientists in biomedical and translational research. It will focus on training individuals with MDs or MD/PhDs selected from a pool of participants in the Pediatric Hematology-Oncology Fellowship Program at CHLA/USC in laboratory or clinical/translational research. It is expected that this training program will contribute to replenishing the pool of physician-scientists in translational biomedical research.

Agency
National Institute of Health (NIH)
Type
Institutional National Research Service Award (T32)
Project #
5T32CA009659-20
Application #
8738614
Study Section
Subcommittee B - Comprehensiveness (NCI)
Program Officer
Lim, Susan E
Project Start
Project End
Budget Start
Budget End
Support Year
20
Fiscal Year
2014
Total Cost
Indirect Cost
Name
Children's Hospital of Los Angeles
Department
Type
DUNS #
City
Los Angeles
State
CA
Country
United States
Zip Code
90027
Cooper, Aaron; van Doorninck, John; Ji, Lingyun et al. (2011) Ewing tumors that do not overexpress BMI-1 are a distinct molecular subclass with variant biology: a report from the Children's Oncology Group. Clin Cancer Res 17:56-66
Gruber, Tanja Andrea; Chang, Mi Sook; Sposto, Richard et al. (2010) Activation-induced cytidine deaminase accelerates clonal evolution in BCR-ABL1-driven B-cell lineage acute lymphoblastic leukemia. Cancer Res 70:7411-20
van Doorninck, John A; Ji, Lingyun; Schaub, Betty et al. (2010) Current treatment protocols have eliminated the prognostic advantage of type 1 fusions in Ewing sarcoma: a report from the Children's Oncology Group. J Clin Oncol 28:1989-94
Trageser, Daniel; Iacobucci, Ilaria; Nahar, Rahul et al. (2009) Pre-B cell receptor-mediated cell cycle arrest in Philadelphia chromosome-positive acute lymphoblastic leukemia requires IKAROS function. J Exp Med 206:1739-53
Jariwala, Unnati; Cogan, Jon P; Jia, Li et al. (2009) Inhibition of AR-mediated transcription by binding of Oct1 to a motif enriched in AR-occupied regions. Prostate 69:392-400
Li, Angela Y J; Boo, Lee Ming; Wang, Shih-Ya et al. (2009) Suppression of nonhomologous end joining repair by overexpression of HMGA2. Cancer Res 69:5699-706
Johnson, Sandra A S; Dubeau, Louis; Johnson, Deborah L (2008) Enhanced RNA polymerase III-dependent transcription is required for oncogenic transformation. J Biol Chem 283:19184-91
Jia, Li; Berman, Benjamin P; Jariwala, Unnati et al. (2008) Genomic androgen receptor-occupied regions with different functions, defined by histone acetylation, coregulators and transcriptional capacity. PLoS One 3:e3645
Douglas, Dorothea; Hsu, Jessie Hao-Ru; Hung, Long et al. (2008) BMI-1 promotes ewing sarcoma tumorigenicity independent of CDKN2A repression. Cancer Res 68:6507-15
Da Silva, Diane M; Fausch, Steven C; Verbeek, J Sjef et al. (2007) Uptake of human papillomavirus virus-like particles by dendritic cells is mediated by Fcgamma receptors and contributes to acquisition of T cell immunity. J Immunol 178:7587-97

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