The present proposal represents a continuation of the Cancer Biology Training Program that was instituted at Duke University in 1993 with the assistance of funding from this training grant. In the past four years, the primary mission of the program has been the training both predoctoral students and postdoctoral fellows for a career in cancer research. All 47 participating faculty from six basic science departments and five clinical departments of Duke University Medical Center contribute time through mentorship, membership on the advisory thesis committees, lecturing in courses, and participation in seminars and works-in-progress meetings. Built on top of the strengths of research in mechanism-based basic cancer biology of the original members of the Cancer Biology Program, there has been a significant increase in participating faculty of the Program with the addition new members who have their main research interests in translational research and first-hand knowledge about cancer therapy and patient care which has dramatically expanded the spectrum of training opportunities for the trainees who want to have a broad exposure to modern cancer biology. Each Program member also participates in other interdisciplinary training programs, and the majority of the faculty are also very involved in postdoctoral training. Both students and postdoctoral fellows are also provided with career guidance and development. The latter includes opportunities for the trainees to meet eminent scientists that come to Duke through a seminar series to present their own work both in classroom situations and at regional and national meetings, and to receive personal career guidance from both visiting scientists and those associated with the Program. There are currently 50 students, from year one to six, working toward the Ph.D. degree in the Program, with two of them receiving direct financial support annually from the training grant. There are six postdoctoral trainees per year who receive financial support from the training grant, with two in each of 0,1, and 2 years of post-graduate experience. For the next funding cycle, 10 student-years and 30 postdoctoral-years of support are projected to come from this training grant. Through the Cancer Biology Training Program, both predoctoral and postdoctoral trainees will receive training that prepares them for competitive research in the field of cancer biology at the highest level. These trainees, in turn, are contributing greatly to the scientific life of this University.

Public Health Relevance

Even with the tremendous progress that has been made in combating cancer as a disease through a better understanding of the underlying mechanisms, cancer remains a major challenge of human health. Training of the next generation of cancer biologists will have a significant impact in the long term fight against this disease.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Institutional National Research Service Award (T32)
Project #
5T32CA059365-19
Application #
8514536
Study Section
Subcommittee G - Education (NCI)
Program Officer
Damico, Mark W
Project Start
1993-07-01
Project End
2015-06-30
Budget Start
2013-07-01
Budget End
2014-06-30
Support Year
19
Fiscal Year
2013
Total Cost
$390,186
Indirect Cost
$28,568
Name
Duke University
Department
Pharmacology
Type
Schools of Medicine
DUNS #
044387793
City
Durham
State
NC
Country
United States
Zip Code
27705
Crose, Lisa E S; Galindo, Kathleen A; Kephart, Julie Grondin et al. (2014) Alveolar rhabdomyosarcoma-associated PAX3-FOXO1 promotes tumorigenesis via Hippo pathway suppression. J Clin Invest 124:285-96
Huynh, Frank K; Green, Michelle F; Koves, Timothy R et al. (2014) Measurement of fatty acid oxidation rates in animal tissues and cell lines. Methods Enzymol 542:391-405
Wang, Qinhong; Goldstein, Michael; Alexander, Peter et al. (2014) Rad17 recruits the MRE11-RAD50-NBS1 complex to regulate the cellular response to DNA double-strand breaks. EMBO J 33:862-77
Reitman, Zachary J; Duncan, Christopher G; Poteet, Ethan et al. (2014) Cancer-associated isocitrate dehydrogenase 1 (IDH1) R132H mutation and d-2-hydroxyglutarate stimulate glutamine metabolism under hypoxia. J Biol Chem 289:23318-28
Lento, William; Ito, Takahiro; Zhao, Chen et al. (2014) Loss of ?-catenin triggers oxidative stress and impairs hematopoietic regeneration. Genes Dev 28:995-1004
Tan, Minjia; Peng, Chao; Anderson, Kristin A et al. (2014) Lysine glutarylation is a protein posttranslational modification regulated by SIRT5. Cell Metab 19:605-17
Turski, Michelle L; Brady, Donita C; Kim, Hyung J et al. (2012) A novel role for copper in Ras/mitogen-activated protein kinase signaling. Mol Cell Biol 32:1284-95
Wardell, Suzanne E; Ilkayeva, Olga R; Wieman, Heather L et al. (2009) Glucose metabolism as a target of histone deacetylase inhibitors. Mol Endocrinol 23:388-401
Yeh, Elizabeth S; Lew, Brian O; Means, Anthony R (2006) The loss of PIN1 deregulates cyclin E and sensitizes mouse embryo fibroblasts to genomic instability. J Biol Chem 281:241-51
van Drogen, Frank; Sangfelt, Olle; Malyukova, Aljona et al. (2006) Ubiquitylation of cyclin E requires the sequential function of SCF complexes containing distinct hCdc4 isoforms. Mol Cell 23:37-48

Showing the most recent 10 out of 12 publications