This is a resubmitted application requesting support for the continuation of a highly successful and well-established postdoctoral training program in molecular imaging and cancer systems analysis, a program that is currently in its tenth year. Currently, there are very few broad, in- depth and interdisciplinary training opportunities that enable individuals to develop and validate novel and non-invasive methods for detecting molecular and cellular processes in vivo, and which could ultimately be used in patients. Such a training program exists at the Center for Systems Biology at Massachusetts General Hospital and includes members of the two NIH- designated Cancer Centers as well as faculty at Harvard Medical School and at Massachusetts Institute of Technology. This training grant is in its tenth year of funding and has had a total of 30 trainees (four trainee positions in years 1-5, six trainee positions thereafter). Twenty five trainees have graduated from the program, the majority of which are now in academia. Overall, trainees have published over 130 peer-reviewed publications to date. The faculty (34 members) are highly accomplished and currently receive over 250 extramural research grants. In the past several years, this training program has had many more applicants than it has been able to accommodate. The curriculum, which includes formal courses, laboratory exercises and individual research projects, is firmly established and trainee research is regularly monitored by their preceptors. Successful programs have also been developed for recruitment of underrepresented minorities and women, scientific integrity and for cancer-related training and research. More recently, the training program has been considerably strengthened by a move to new research facilities, the introduction of a new Chemical Biology Program, the implementation of a computational program in addition to an expanded imaging facility. With our current faculty, enhanced facilities, scope of supported research and past accomplishments, we offer an outstanding research environment for the next generation of clinicians and scientists to be trained in molecular imaging and systems analysis.

Public Health Relevance

The goal of this application is to continue the funding of a highly successful and well-established postdoctoral training program in the field of molecular imaging and cancer systems analysis. Currently, few opportunities currently exist that provide broad, in-depth and interdisciplinary training for individuals to develop and validate novel and non-invasive methods capable of detecting molecular and cellular processes in vivo, and which could ultimately be used in patients.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Institutional National Research Service Award (T32)
Project #
2T32CA079443-11A1
Application #
8128172
Study Section
Subcommittee G - Education (NCI)
Program Officer
Damico, Mark W
Project Start
2000-03-16
Project End
2016-06-30
Budget Start
2011-07-01
Budget End
2012-06-30
Support Year
11
Fiscal Year
2011
Total Cost
$450,805
Indirect Cost
Name
Massachusetts General Hospital
Department
Type
DUNS #
073130411
City
Boston
State
MA
Country
United States
Zip Code
02199
Cuccarese, Michael F; Dubach, J Matthew; Pfirschke, Christina et al. (2017) Heterogeneity of macrophage infiltration and therapeutic response in lung carcinoma revealed by 3D organ imaging. Nat Commun 8:14293
Park, Yong Il; Kim, Eunha; Huang, Chen-Han et al. (2017) Facile Coating Strategy to Functionalize Inorganic Nanoparticles for Biosensing. Bioconjug Chem 28:33-37
Dubach, J Matthew; Kim, Eunha; Yang, Katherine et al. (2017) Quantitating drug-target engagement in single cells in vitro and in vivo. Nat Chem Biol 13:168-173
Arlauckas, Sean P; Garris, Christopher S; Kohler, Rainer H et al. (2017) In vivo imaging reveals a tumor-associated macrophage-mediated resistance pathway in anti-PD-1 therapy. Sci Transl Med 9:
Miller, Miles A; Weissleder, Ralph (2017) Imaging of anticancer drug action in single cells. Nat Rev Cancer 17:399-414
Miller, Miles A; Weissleder, Ralph (2017) Imaging the pharmacology of nanomaterials by intravital microscopy: Toward understanding their biological behavior. Adv Drug Deliv Rev 113:61-86
Im, Hyungsoon; Park, Yong Il; Pathania, Divya et al. (2016) Digital diffraction detection of protein markers for avian influenza. Lab Chip 16:1340-5
Giedt, Randy J; Fumene Feruglio, Paolo; Pathania, Divya et al. (2016) Computational imaging reveals mitochondrial morphology as a biomarker of cancer phenotype and drug response. Sci Rep 6:32985
Pucci, Ferdinando; Garris, Christopher; Lai, Charles P et al. (2016) SCS macrophages suppress melanoma by restricting tumor-derived vesicle-B cell interactions. Science 352:242-6
Pathania, Divya; Im, Hyungsoon; Kilcoyne, Aoife et al. (2016) Holographic Assessment of Lymphoma Tissue (HALT) for Global Oncology Field Applications. Theranostics 6:1603-10

Showing the most recent 10 out of 115 publications