The goal of this program is to continue to provide broad based interdisciplinary cancer research training for five predoctoral and five postdoctoral fellows. Trainees funded by this program will work with two faculty members whose complementary research interests lie in basic sciences, clinical research or public health sciences. In order to obtain funding through this training grant, fellows must submit research proposals relevant to the etiology or treatment of cancer that draw upon expertise found in two or more disciplines and identify two mentors who agree to supervise the project. This training program is the centerpiece of an overall initiative in interdisciplinary cancer research at the Fred Hutchinson Cancer Research Center (FHCRC) and the University of Washington (UW). The long-term goal is to increase the pool of investigators who have training and expertise in cross-disciplinary applications of the rapidly expanding knowledge base in biomedical science relevant to cancer and other human diseases. Examples of such cross disciplinary training are basic science students who have two advisors who are a basic scientist and an epidemiologist, or clinical fellows who also have a basic science or a public health science advisor for portions of the work. The research experience will be supported by selection from a wide range of didactic training opportunities appropriate to the needs of the individual trainee and available at the two institutions, including research meetings, classes, journal clubs and seminars. All trainees will present their work annually at a research colloquium. An additional component of this program is support of predoctoral students who wish to obtain an M.S. degree in Epidemiology, concurrent with a Ph.D. in a basic science. A concurrent Dual Degree program has been established at the University of Washington to allow this type of interdisciplinary training in an efficient manner. Trainees will be recruited from the pool of predoctoral and postdoctoral trainees presently working at the two institutions. In addition, trainees can learn about specific interdisciplinary research opportunities through a web site devoted to dual mentor projects. This web site, and the projects therein, will be advertised locally and nationally, so that postdoctoral trainees from other institutions can also apply to the program.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Institutional National Research Service Award (T32)
Project #
2T32CA080416-06A1
Application #
6748288
Study Section
Subcommittee G - Education (NCI)
Program Officer
Eckstein, David J
Project Start
1998-08-11
Project End
2009-04-30
Budget Start
2004-05-10
Budget End
2005-04-30
Support Year
6
Fiscal Year
2004
Total Cost
$426,496
Indirect Cost
Name
University of Washington
Department
Microbiology/Immun/Virology
Type
Schools of Medicine
DUNS #
605799469
City
Seattle
State
WA
Country
United States
Zip Code
98195
Bender Ignacio, Rachel A; Madison, Amy T; Moshiri, Ata et al. (2018) A Population-based Study of Perinatal Infection Risk in Women with and without Systemic Lupus Erythematosus and their Infants. Paediatr Perinat Epidemiol 32:81-89
Ferreccio, Amy; Mathieu, Julie; Detraux, Damien et al. (2018) Inducible CRISPR genome editing platform in naive human embryonic stem cells reveals JARID2 function in self-renewal. Cell Cycle 17:535-549
Gupta, Amitabha; Evans, Rena K; Koch, Lori B et al. (2018) Purification of kinetochores from the budding yeast Saccharomyces cerevisiae. Methods Cell Biol 144:349-370
Oseso, Linda N; Chiao, Elizabeth Y; Ignacio, Rachel A Bender (2018) Evaluating Antiretroviral Therapy Initiation in HIV-Associated Malignancy: Is There Enough Evidence to Inform Clinical Guidelines? J Natl Compr Canc Netw 16:927-932
Poudel, Kumud R; Roh-Johnson, Minna; Su, Allen et al. (2018) Competition between TIAM1 and Membranes Balances Endophilin A3 Activity in Cancer Metastasis. Dev Cell 45:738-752.e6
LlaurĂ³, Aida; Hayashi, Hanako; Bailey, Megan E et al. (2018) The kinetoplastid kinetochore protein KKT4 is an unconventional microtubule tip-coupling protein. J Cell Biol 217:3886-3900
Matreyek, Kenneth A; Starita, Lea M; Stephany, Jason J et al. (2018) Multiplex assessment of protein variant abundance by massively parallel sequencing. Nat Genet 50:874-882
Stewart, Mikaela D; Zelin, Elena; Dhall, Abhinav et al. (2018) BARD1 is necessary for ubiquitylation of nucleosomal histone H2A and for transcriptional regulation of estrogen metabolism genes. Proc Natl Acad Sci U S A 115:1316-1321
Suzuki, Aussie; Gupta, Amitabha; Long, Sarah K et al. (2018) A Kinesin-5, Cin8, Recruits Protein Phosphatase 1 to Kinetochores and Regulates Chromosome Segregation. Curr Biol 28:2697-2704.e3
Munson, Paul; Liu, Yi; Bratt, Debra et al. (2018) Therapeutic conserved elements (CE) DNA vaccine induces strong T-cell responses against highly conserved viral sequences during simian-human immunodeficiency virus infection. Hum Vaccin Immunother 14:1820-1831

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