The purpose of this training program is to prepare postdoctoral researchers for careers in immunologic research that will enable them to have a significant impact on the prevention, diagnosis and treatment of cancer. Over the past decade the field of immunology has witnessed an unprecedented level of discovery on every front. These exciting advances have led to an improved understanding of how cancers evade the immune system and how innate and specific immunity can be manipulated to generate an anti-tumor immune response. In order to translate this new knowledge into effective treatments for cancer, it will be necessary to train a new generation of immunologists who are well-versed in the most recent concepts in immunology. Trainees will engage in an intensive program of immunologic research under the guidance of an accomplished mentor with expertise in a specific area of immunology. This will permit the young investigator to develop a focused immunologic research question and relate it to important clinical and scientific problems. In order that they have thorough exposure to the principles underlying the conduct of immunologic research, trainees will participate in a carefully designed program of courses, conferences, and meetings sponsored by the Ohio State University Comprehensive Cancer Center (OSUCCC) and the Immunology Program. Trainees will also benefit from significant exposure to related disciplines such as bioinformatics, biostatistics, human cancer genetics, translational medicine, and experimental therapeutics, as well as training in grant writing and the responsible conduct of research. Trainees will be introduced to state of the art methodologies and scientific techniques. This program will encourage the participation of both physician-scientists and trainees with a basic science background in order to enhance the exchange of ideas, stimulate intellectual curiosity, and broaden the perspectives of the participants. There has been and will continue to be a concerted effort to recruit persons from under-represented groups into this program. Successful completion of this inter-disciplinary training program will foster the development of the trainee's scientific research skills in preparation for an immunologic research career that will have a positive impact on the health needs of our nation's cancer patients. Indeed, all 13 former trainees have continued with academic pursuits and all have maintained the expected career trajectory. Twelve of these former trainees are still involved in tumor immunology research. Four of the more senior alumni have successfully competed for peer-reviewed K level funding and one has received an American Cancer Society Post-Doctoral Fellowship Award. Since the last renewal, four trainees from under-represented groups were recruited to this training program.

Public Health Relevance

The purpose of this training program is to prepare post-doctoral researchers for careers in immunologic research so that they can have a significant impact on the prevention, diagnosis and treatment of cancer. Successful completion of this will foster the development of the trainee's scientific research skills in preparation for an immunologic research career that will have a positive impact on the health needs of our nation's cancer patients.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Institutional National Research Service Award (T32)
Project #
2T32CA090223-11
Application #
8475203
Study Section
Subcommittee G - Education (NCI)
Program Officer
Damico, Mark W
Project Start
2001-01-01
Project End
2018-07-31
Budget Start
2013-08-23
Budget End
2014-07-31
Support Year
11
Fiscal Year
2013
Total Cost
$243,354
Indirect Cost
$17,226
Name
Ohio State University
Department
Surgery
Type
Schools of Medicine
DUNS #
832127323
City
Columbus
State
OH
Country
United States
Zip Code
43210
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Markowitz, Joseph; Luedke, Eric A; Grignol, Valerie P et al. (2014) A phase I trial of bortezomib and interferon-*-2b in metastatic melanoma. J Immunother 37:55-62
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Markowitz, Joseph; Wesolowski, Robert; Papenfuss, Tracey et al. (2013) Myeloid-derived suppressor cells in breast cancer. Breast Cancer Res Treat 140:13-21

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