This application requests continuing support for post-doctoral training in surgical oncology research for four fellows. The Vanderbilt Department of Surgery has had a continuing commitment to mentored research for both resident research fellows and junior surgical oncology research faculty. Given the rapid pace and complexity of both basic and clinical research, it is imperative to provide trainees with the requisite armamentarium of investigative skills during post-doctoral training. The establishment of both research proficiency and a pattern of mentored training are critical for the promotion of successful academic career pathways. Importantly, configured a multidisciplinary training program to allow development of investigators along basic, patient- oriented or clinical research tracks. All three of these research paradigms are considered crucial to the success of broad-based cancer related investigation. The objective of this program is to prepare surgical residents and post-doctoral fellows for investigative careers in research fields related to surgical oncology. Fellows commit at least two years to intensive training in basic, translational or clinical research through a mentored training environment necessary for the development of experience and proficiency in investigative techniques and reasoning, For those interested in basic science research training, opportunities for mentored investigation are available in the laboratories of scientists with broad interests in cancer biology. In addition to bench research training, fellows in the basic research track will participate in didactic course work as determined by the individual advisory committees. Fellows interested in patient-oriented research training will pursue a Masters of Science in Clinical Investigation (MSCI). The MSCI program combines broad didactic coursework with a mentored research experience focused on patient related material or therapeutic intervention. Finally, those interested in epidemiological or outcomes research will pursue a Masters of Public Health (MPH). The MPH program combines didactic coursework in clinical epidemiology with a mentored clinical research project. These three training tracks allow fellows to pursue pathways best suited to their career objectives.

Public Health Relevance

Surgeons remain at the forefront of the care for patients with cancer. The clinical experience of surgeons give them a particular perspective on cancer. There is a need for research expertise among surgeons and those interested in surgical oncology so that these individuals are fully prepared to tackle the important future research needs in basic cancer biology, translational cancer research and cancer epidemiology.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Institutional National Research Service Award (T32)
Project #
5T32CA106183-10
Application #
8689952
Study Section
Subcommittee B - Comprehensiveness (NCI)
Program Officer
Damico, Mark W
Project Start
2004-09-30
Project End
2015-06-30
Budget Start
2014-07-01
Budget End
2015-06-30
Support Year
10
Fiscal Year
2014
Total Cost
Indirect Cost
Name
Vanderbilt University Medical Center
Department
Surgery
Type
Schools of Medicine
DUNS #
City
Nashville
State
TN
Country
United States
Zip Code
37212
Tyson 2nd, Mark D; Ark, Jacob; Gregg, Justin R et al. (2017) The Null Effect of Bladder Neck Size on Incontinence Outcomes after Radical Prostatectomy. J Urol 198:1404-1408
Tyson, Mark D; Lee, Daniel; Clark, Peter (2017) New developments in the management of nonmuscle invasive bladder cancer. Curr Opin Oncol :
Lang, Maximilian F; Tyson, Mark D; Alvarez, JoAnn Rudd et al. (2017) The Influence of Psychosocial Constructs on the Adherence to Active Surveillance for Localized Prostate Cancer in a Prospective, Population-based Cohort. Urology 103:173-178
O'Neil, Andrew; Petersen, Christine P; Choi, Eunyoung et al. (2017) Unique Cellular Lineage Composition of the First Gland of the Mouse Gastric Corpus. J Histochem Cytochem 65:47-58
Tyson, Mark D; Penson, David F; Resnick, Matthew J (2017) The comparative oncologic effectiveness of available management strategies for clinically localized prostate cancer. Urol Oncol 35:51-58
Petersen, Christine P; Meyer, Anne R; De Salvo, Carlo et al. (2017) A signalling cascade of IL-33 to IL-13 regulates metaplasia in the mouse stomach. Gut :
Rellinger, Eric J; Padmanabhan, Chandrasekhar; Qiao, Jingbo et al. (2017) Isoxazole compound ML327 blocks MYC expression and tumor formation in neuroblastoma. Oncotarget 8:91040-91051
Tyson, Mark D; Barocas, Daniel A (2017) Improving quality through clinical registries in urology. Curr Opin Urol 27:375-379
Barocas, Daniel A; Alvarez, JoAnn; Resnick, Matthew J et al. (2017) Association Between Radiation Therapy, Surgery, or Observation for Localized Prostate Cancer and Patient-Reported Outcomes After 3 Years. JAMA 317:1126-1140
Padmanabhan, Chandrasekhar; Rellinger, Eric J; Zhu, Jing et al. (2017) cFLIP critically modulates apoptotic resistance in epithelial-to-mesenchymal transition. Oncotarget 8:101072-101086

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