20% of all human cancers are associated with viruses functioning as biological cofactors in driving these cancers. Some of these viruses may have a direct role in mediating these cancers as in the case of HIV related cancers which includes Kaposi's sarcoma, pleural effusion lymphomas and lymphoproliferative disease. There is also an increase in the number of HPV related patients for example in the immunocompromised patients who are on HAART therapy and in head and neck squamous cell carcinomas. The Tumor Virology Training Program at the University of Pennsylvania serves as the central forum for facilitating interactions among investigators involved in cancer-related viral research on the Penn campus which provides a more directed training for trainees. Program members have expertise in EBV, KSHV, HPV, HCV, HIV and other retroviruses. The biomedical community at Penn would like to continue the momentum of this training program in Tumor Virology for training predoctoral and postdoctoral students. There are 18 trainers in this program all of whom are committed to training pre and postdoctoral fellows for biomedical research careers. All faculty have well-funded NIH programs supported by the R21, R01, R43 or P01 mechanism, DOD and other private foundation monies. The training program seeks to continue support of 2 predoctoral and 4 postdoctoral students annually for each of the 5 years of funding. The number of trainees in labs of the trainers of this program has been consistently increasing and we anticipate this trend continuing in the coming years. Thus, we would like to have available slots for this continued increase in the number of predoctoral and postdoctoral candidates in the program. Viral related cancers are expected to increase as the technology for identifying these agents improves. We expect to provide an atmosphere of collaboration between clinical and basic scientists for our trainees who will have the opportunity to formulate ideas which will lead to basic and translational studies initiating and maintaining a cohesive group in tumor virology. The increased incidence of viral associated cancers, the commitment of the trainers and the institution with a well organized training program will provide an outstanding training environment for pre and postdoctoral candidates in tumor virology.
The Tumor Virology program supports 2 pre doctoral and 4 post-doctoral trainees every year and provides an intellectual environment for the training of these individuals with a directed focus in Tumor Virology. We have been extremely proud of the progress we have made with providing one of the cutting edge programs in the country in this area. Tumor viruses are an important area of study with about 20% of human cancers now associated with viral agents and so this puts our training in a perfect position for a successful career in the next 5-10 years.
|Stavrou, Spyridon; Crawford, Daniel; Blouch, Kristin et al. (2014) Different modes of retrovirus restriction by human APOBEC3A and APOBEC3G in vivo. PLoS Pathog 10:e1004145|
|Psathas, James N; Thomas-Tikhonenko, Andrei (2014) MYC and the art of microRNA maintenance. Cold Spring Harb Perspect Med 4:|
|Tsang, Sabrina H; Wang, Xin; Li, Jing et al. (2014) Host DNA damage response factors localize to merkel cell polyomavirus DNA replication sites to support efficient viral DNA replication. J Virol 88:3285-97|
|Yan, Jian; Villarreal, Daniel O; Racine, Trina et al. (2014) Protective immunity to H7N9 influenza viruses elicited by synthetic DNA vaccine. Vaccine 32:2833-42|
|Villarreal, Daniel O; Wise, Megan C; Walters, Jewell N et al. (2014) Alarmin IL-33 acts as an immunoadjuvant to enhance antigen-specific tumor immunity. Cancer Res 74:1789-800|
|Villarreal, Daniel O; Walters, Jewell; Laddy, Dominick J et al. (2014) Multivalent TB vaccines targeting the esx gene family generate potent and broad cell-mediated immune responses superior to BCG. Hum Vaccin Immunother 10:|
|Wong, Gabrielle S; Habibollahi, Peiman; Heidari, Pedram et al. (2013) Optical imaging of periostin enables early endoscopic detection and characterization of esophageal cancer in mice. Gastroenterology 144:294-7|
|Stavrou, Spyridon; Nitta, Takayuki; Kotla, Swathi et al. (2013) Murine leukemia virus glycosylated Gag blocks apolipoprotein B editing complex 3 and cytosolic sensor access to the reverse transcription complex. Proc Natl Acad Sci U S A 110:9078-83|
|Wong, G S; Rustgi, A K (2013) Matricellular proteins: priming the tumour microenvironment for cancer development and metastasis. Br J Cancer 108:755-61|
|Jaber, Tareq; Yuan, Yan (2013) A virally encoded small peptide regulates RTA stability and facilitates Kaposi's sarcoma-associated herpesvirus lytic replication. J Virol 87:3461-70|
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