This proposal from the Texas Children's Cancer Center at Baylor College of Medicine seeks to establish a novel, three-year Pediatric Oncology Research Training (PORT) Program for outstanding pediatric hematology-oncology fellows who have chosen to pursue a laboratory-based pediatric cancer research career. The rationale for developing this program is based on the premise that standard Pediatric Hematology-Oncology Fellowship programs do not provide an adequate laboratory research training experience for trainees interested in becoming laboratory-based physician-scientists. The PORT program has been specifically designed to address this issue by providing its highly selected trainees with a focused mentored research and didactic program that will ultimately enable them to become successful, independently funded, laboratory investigators. The program utilizes the significant strengths and resources of the Texas Children's Cancer Center (TCCC), Texas Children's Hospital (TCH), Baylor College of Medicine (BCM), the BCM Cancer Center (BCMCC), the Department of Pediatrics, and the 5 Departments of the 24 participating mentors. ? ? The PORT program will provide the up to 6 postdoctoral trainees (two per year) the opportunity to choose a laboratory research experience in either basic research or translational research. The proposed training program has several unique features. First, trainees enter the program following a comprehensive year of clinical training where, because of the size and breadth of the program, they have had in-depth exposure to the major clinical and scientific challenges in the field. This provides them with a strong basis from which to choose their particular field of research and their specific mentor. Second, the program is comprised of a superb group of research mentors with vast teaching and training experience and a sincere commitment to training young physician scientists. Third, the proposed program is a highly structured one that has many elements similar to those characteristic of PhD graduate training programs including a structured didactic program with graduate level courses, seminars, and conferences and an individual Scholarship Oversight Committee that monitors the progress of each trainee. Fourth, trainees participate in research retreats and national conferences and workshops and attend a novel leadership-training seminar designed to provide them with the skills needed to become leaders in the field. ? ? ? ?

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Institutional National Research Service Award (T32)
Project #
5T32CA115303-02
Application #
7271215
Study Section
Special Emphasis Panel (ZCA1-RTRB-A (M1))
Program Officer
Gorelic, Lester S
Project Start
2006-08-04
Project End
2011-06-30
Budget Start
2007-07-01
Budget End
2008-06-30
Support Year
2
Fiscal Year
2007
Total Cost
$247,123
Indirect Cost
Name
Baylor College of Medicine
Department
Pediatrics
Type
Schools of Medicine
DUNS #
051113330
City
Houston
State
TX
Country
United States
Zip Code
77030
Baxter, Patricia A; Lin, Qi; Mao, Hua et al. (2014) Silencing BMI1 eliminates tumor formation of pediatric glioma CD133+ cells not by affecting known targets but by down-regulating a novel set of core genes. Acta Neuropathol Commun 2:160
Flores, Ricardo J; Li, Yiting; Yu, Alexander et al. (2012) A systems biology approach reveals common metastatic pathways in osteosarcoma. BMC Syst Biol 6:50
Daves, Marla H; Hilsenbeck, Susan G; Lau, Ching C et al. (2011) Meta-analysis of multiple microarray datasets reveals a common gene signature of metastasis in solid tumors. BMC Med Genomics 4:56
Dettman, E J; Simko, S J; Ayanga, B et al. (2011) Prdm14 initiates lymphoblastic leukemia after expanding a population of cells resembling common lymphoid progenitors. Oncogene 30:2859-73
Allen, Carl E; Li, Liunan; Peters, Tricia L et al. (2010) Cell-specific gene expression in Langerhans cell histiocytosis lesions reveals a distinct profile compared with epidermal Langerhans cells. J Immunol 184:4557-67
Allen, Carl E; McClain, Kenneth L (2009) Interleukin-17A is not expressed by CD207(+) cells in Langerhans cell histiocytosis lesions. Nat Med 15:483-4; author reply 484-5
Sun, Wenjing; Yu, Yang; Dotti, Gianpietro et al. (2009) PPM1A and PPM1B act as IKKbeta phosphatases to terminate TNFalpha-induced IKKbeta-NF-kappaB activation. Cell Signal 21:95-102
Yu, Yang; Ge, Ningling; Xie, Min et al. (2008) Phosphorylation of Thr-178 and Thr-184 in the TAK1 T-loop is required for interleukin (IL)-1-mediated optimal NFkappaB and AP-1 activation as well as IL-6 gene expression. J Biol Chem 283:24497-505