This Ruth L Kirschstein National Research Service Award Postdoctoral Research Training Grant proposal is submitted in response to Program Announcement # PA-06-468 for applications to provide institutional T32 awards to train young researchers who will become independent investigators who will address important problems in human health. The application requests resources to support four physician/scientists each year with MD or MD/PhD degrees who will receive mentored research that focuses on the etiology, pathogenesis, and treatment of pediatric malignancies. The long-term goal of this program is to train new investigators who will improve the care of children with cancer. The rationale for the program is based on the well-documented need to provide mentored career development support for young scientists that will enable them to become fully independent and productive laboratory researchers. As such, they will be poised to improve the health of children with cancer throughout the world by bringing state-of-the-art expertise to bear on problems such as inherited predispostions, environmental factors, the toxic and relatively non-specific nature of current therapies, and long-term adverse effects of mutagenic treatments. The design of this program involves harnessing the expertise of world-class research scientists who will serve as mentors for interdisciplinary training. We believe UCSF has the vision, experience, and infrastructure to train the next generation of leaders in childhood cancer research. In this application, we provide evidence that the Department together with the broader UCSF research community comprise an exceptional environment for preparing young investigators for productive careers in this field and describe a comprehensive plan for training these individuals. This application is directly relevant to human health as it requests funds to support mentored career development for outstanding young physician/scientists who will become independent researchers in the field of childhood cancer. Programs like this one represent an investment in the future of public health as the researchers who are trained through this award will be equipped to harness state-of-the-art research techniques to attack a formidable health problem in the pediatric population. The long-term outcome of intensive and innovative training provided by this T32 award will be effective new treatments for childhood cancers.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Institutional National Research Service Award (T32)
Project #
5T32CA128583-05
Application #
8098092
Study Section
Special Emphasis Panel (ZCA1-RTRB-A (M1))
Program Officer
Lim, Susan E
Project Start
2007-07-01
Project End
2012-06-30
Budget Start
2011-07-01
Budget End
2012-06-30
Support Year
5
Fiscal Year
2011
Total Cost
$258,166
Indirect Cost
Name
University of California San Francisco
Department
Pediatrics
Type
Schools of Medicine
DUNS #
094878337
City
San Francisco
State
CA
Country
United States
Zip Code
94143
Kumar, Prerna; Gill, Ryan M; Phelps, Andrew et al. (2018) Surveillance Screening in Li-Fraumeni Syndrome: Raising Awareness of False Positives. Cureus 10:e2527
Kline, Cassie; Felton, Erin; Allen, I Elaine et al. (2018) Survival outcomes in pediatric recurrent high-grade glioma: results of a 20-year systematic review and meta-analysis. J Neurooncol 137:103-110
Tolbert, Vanessa P; Matthay, Katherine K (2018) Neuroblastoma: clinical and biological approach to risk stratification and treatment. Cell Tissue Res 372:195-209
Wang, David; Quiros, Jason; Mahuron, Kelly et al. (2018) Targeting EZH2 Reprograms Intratumoral Regulatory T Cells to Enhance Cancer Immunity. Cell Rep 23:3262-3274
Dvorak, Christopher C; Satwani, Prakash; Stieglitz, Elliot et al. (2018) Disease burden and conditioning regimens in ASCT1221, a randomized phase II trial in children with juvenile myelomonocytic leukemia: A Children's Oncology Group study. Pediatr Blood Cancer 65:e27034
Forester, Craig M; Zhao, Qian; Phillips, Nancy J et al. (2018) Revealing nascent proteomics in signaling pathways and cell differentiation. Proc Natl Acad Sci U S A 115:2353-2358
Stieglitz, Elliot; Mazor, Tali; Olshen, Adam B et al. (2017) Genome-wide DNA methylation is predictive of outcome in juvenile myelomonocytic leukemia. Nat Commun 8:2127
Vo, Kieuhoa T; Karski, Erin E; Nasholm, Nicole M et al. (2017) Phase 1 study of sirolimus in combination with oral cyclophosphamide and topotecan in children and young adults with relapsed and refractory solid tumors. Oncotarget 8:23851-23861
Kline, Cassie N; Packer, Roger J; Hwang, Eugene I et al. (2017) Case-based review: pediatric medulloblastoma. Neurooncol Pract 4:138-150
Dvorak, Christopher C; Puck, Jennifer M; Wahlstrom, Justin T et al. (2017) Neurologic event-free survival demonstrates a benefit for SCID patients diagnosed by newborn screening. Blood Adv 1:1694-1698

Showing the most recent 10 out of 95 publications